• total body iron is decreased (J:6052)

• defect in placental iron transport; when iron is administered continuously in food of pregnant females, a significant reduction in iron transfer to mutant fetuses is observed (J:6052)

• increased iron loading in the mucosa of the proximal duodenum (J:62112)

• increased iron loading in the mucosa of the proximal duodenum (J:62112)

• reduction in hematopoietic tissue in both the liver and bone marrow (J:64261)

• red blood cell count is reduced to about 3/4 of the normal value (J:64261)

• slight reduction (J:64261)

• slight reduction in mean cell volume (J:128474)

• anemia is most severe at a young age and tends to diminish with increasing age (J:128474)

• iron-dextran injection resolves the anemia (J:128474)

• erythrocytes show great variation in size and form (J:128474)

• some cells are macrocytic (J:128474)

• many microcytic cells (J:128474)

• macrocytic cells with marked polychromasia (J:128474)

• increased iron loading in the mucosa of the proximal duodenum (J:62112)

• increased hepatic iron loading (J:62112)

• less hepatic iron loading than than the single Hfe^tm2Nca homozygous mutant (J:62112)

• increased iron loading in the mucosa of the proximal duodenum (J:62112)

• increased hepatic iron loading (J:62112)

• less hepatic iron loading than than the single Hfe^tm2Nca homozygous mutant (J:62112)

• increased iron loading in the mucosa of the proximal duodenum (J:62112)

• increased hepatic iron loading (J:62112)

• less hepatic iron loading than than the single Hfe^tm2Nca homozygous mutant (J:62112)

• increased iron loading in the mucosa of the proximal duodenum (J:62112)

• increased hepatic iron loading (J:62112)

• less hepatic iron loading than than the single Hfe^tm2Nca homozygous mutant (J:62112)

• retinas exhibit increased iron at 5-6 months of age, with highest levels in the RPE and photoreceptor outer segments (J:92620)

• levels of the cytosolic iron storage protein ferritin are increased in retinas (J:92620)

• choroidal thinning (J:92620)

• retinas exhibit increased iron at 5-6 months of age, with highest levels in the RPE and photoreceptor outer segments (J:92620)

• age dependent subretinal neovascularization (J:92620)

• local photoreceptor degeneration (J:92620)

• age dependent retinal epithelium hypertrophy, hyperplasia and necrosis (J:92620)

• retinas of mutants surviving 6-9 months exhibit focal areas of hypopigmentation in the midperipheral retina (J:92620)

• age dependent retinal epithelium hyperplasia (J:92620)

• mutants surviving 6-9 months exhibit retinal degeneration (J:92620)

• age dependent subretinal neovascularization (J:92620)

• local photoreceptor degeneration (J:92620)

• age dependent retinal epithelium hypertrophy, hyperplasia and necrosis (J:92620)

• retinas of mutants surviving 6-9 months exhibit focal areas of hypopigmentation in the midperipheral retina (J:92620)

• age dependent retinal epithelium hyperplasia (J:92620)

• in the duodenum crypt cells of male mice, the amount of iron deposited after intravenous iron administration is greater than normal, either because of increased avidity or decreased return to plasma (J:5660)

• total body iron is decreased (J:6052)

• defect in placental iron transport; when iron is administered continuously in food of pregnant females, a significant reduction in iron transfer to mutant male fetuses is observed compared to transfer to heterozygous or wild-type male fetuses (J:6052)

• red blood cell protoporphyrin levels are higher than in controls during the neonatal period, however they return to normal levels within 2 months of age (J:5985)

• red blood cell protoporphyrin levels are higher than in controls during the neonatal period, however they return to normal levels within 2 months of age (J:5985)

• red blood counts are reduced to about 75% of the wild-type (J:128474)

• slight reduction in mean corpuscular hemoglobin (J:128474)

• slight reduction in mean cell volume (J:128474)

• anemia is most severe at a young age and tends to diminish with increasing age (J:128474)

• iron-dextran injection resolves the anemia (J:128474)

• erythrocytes show great variation in size and form (J:128474)

• some cells are macrocytic (J:128474)

• many microcytic cells (J:128474)

• macrocytic cells with marked polychromasia (J:128474)