Phenotypes associated with this allele
Allelic Composition |
Cpoxnct/Cpoxnct
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Genetic Background |
involves: BALB/cCrSlc |
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cpoxnct mutation
(1 available);
any
Cpox mutation
(33 available)
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vision/eye
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• at 10 weeks
• however, mice also expression a transgene containing the endogenous gene do not develop cataracts during the 6 month observation period
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cpoxnct mutation
(1 available);
any
Cpox mutation
(33 available)
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vision/eye
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• histological analysis shows slower than normal loss of lens cell nuclei, especially in the bow area, by 7 days of age
(J:5481)
• persistence of cell nuclei in the bow area is noteable at 12-13 days of age
(J:5481)
• there is a decrease in crystallin and leakage of crystallin from the lens
(J:6014)
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• distal portions of many fibers swell and become hydropic
• at 20-23 days of age lens fibers are disintegrating posterior to the center of the lens with histology showing broken cell borders, many vacuoles and large swollen cells
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• an opaque spot first appears in mutant mice between 16 to 22 days of age
• the whole lens is opaque by 4-5 weeks of age
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cpoxnct mutation
(1 available);
any
Cpox mutation
(33 available)
Nctm1BALB/c mutation
(0 available);
any
Nctm1 mutation
(0 available)
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vision/eye
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• decreased cataract severity
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cpoxnct mutation
(1 available);
any
Cpox mutation
(33 available)
Nctm2BALB/c mutation
(0 available);
any
Nctm2 mutation
(0 available)
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vision/eye
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• decreased cataract severity
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