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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Ttnmdm
muscular dystrophy with myositis
MGI:1856953
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Ttnmdm/Ttnmdm involves: C57BL/6J MGI:3041565
hm2
Ttnmdm/Ttnmdm Not Specified MGI:3041561


Genotype
MGI:3041565
hm1
Allelic
Composition
Ttnmdm/Ttnmdm
Genetic
Background
involves: C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ttnmdm mutation (1 available); any Ttn mutation (537 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mice die around 2 months of age

growth/size/body
• weight is reduced to roughly half that of control mice at 24 days of age

muscle
N
• myofibrils were ultrastructurally similar to those of wild-type
• the tension-generating capacity of soleus fibers was normal




Genotype
MGI:3041561
hm2
Allelic
Composition
Ttnmdm/Ttnmdm
Genetic
Background
Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ttnmdm mutation (1 available); any Ttn mutation (537 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mice become very stiff and immobile and most are dead by 2 months of age

immune system
• acute and chronic myositis

muscle
• acute and chronic myositis

skeleton
• the entire thoracic and lumbar spine shows an exaggerated convex curvature by 12 days of age

Mouse Models of Human Disease
OMIM ID Ref(s)
Muscular Dystrophy, Limb-Girdle, Type 2J; LGMD2J 608807 J:74611





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/26/2016
MGI 6.03
The Jackson Laboratory