Mouse Genome Informatics
hm1
    Ttnmdm/Ttnmdm
involves: C57BL/6J
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
mortality/aging
• mice die around 2 months of age

growth/size
• weight is reduced to roughly half that of control mice at 24 days of age

muscle
N
• myofibrils were ultrastructurally similar to those of wild-type (J:87870)
• the tension-generating capacity of soleus fibers was normal (J:87870)


Mouse Genome Informatics
hm2
    Ttnmdm/Ttnmdm
Not Specified
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
mortality/aging
• mice become very stiff and immobile and most are dead by 2 months of age

immune system
• acute and chronic myositis

muscle
• acute and chronic myositis

skeleton
• the entire thoracic and lumbar spine shows an exaggerated convex curvature by 12 days of age

Mouse Models of Human Disease
OMIM IDRef(s)
Muscular Dystrophy, Limb-Girdle, Type 2J; LGMD2J 608807 J:74611