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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Trfhpx
hypotransferrinemia with hemochromatosis
MGI:1856905
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Trfhpx/Trfhpx BALB/cJ-Trfhpx MGI:3037942
ht2
Trfhpx/Trf+ BALB/cJ-Trfhpx MGI:3037943


Genotype
MGI:3037942
hm1
Allelic
Composition
Trfhpx/Trfhpx
Genetic
Background
BALB/cJ-Trfhpx
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trfhpx mutation (1 available); any Trf mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• death by 14 days of age (J:8936)
• injections of purified transferrin, mouse or human serum exteneded life (J:8936)
• death by 14 days of age (J:8936)
• injections of purified transferrin, mouse or human serum exteneded life (J:8936)

growth/size/body

hematopoietic system
• microreticulocytes (J:8936)
• microreticulocytes (J:8936)

homeostasis/metabolism
• increased clearance rates (J:8936)
• increased clearance rates (J:8936)
• increased clearance rate (J:64456)
• increased clearance rate (J:64456)
• progressive hyperferremia (J:8936)
• progressive hyperferremia (J:8936)
• with iron loading visible in the liver, heart, kidney and pancreas (J:8936)
• with iron loading visible in the liver, heart, kidney and pancreas (J:8936)
• with iron loading, visible in the embryonic liver and at 6 months of age in the heart, kidney and pancreas (J:64456)
• with iron loading, visible in the embryonic liver and at 6 months of age in the heart, kidney and pancreas (J:64456)

Mouse Models of Human Disease
OMIM ID Ref(s)
Atransferrinemia 209300 J:8936 , J:64456




Genotype
MGI:3037943
ht2
Allelic
Composition
Trfhpx/Trf+
Genetic
Background
BALB/cJ-Trfhpx
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trfhpx mutation (1 available); any Trf mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
N
• normal blood values (J:64456)
• normal blood values (J:64456)

homeostasis/metabolism
• progressive hyperferremia, but milder and later in life than homozygotes (J:8936)
• progressive hyperferremia, but milder and later in life than homozygotes (J:8936)
• mild (J:8936)
• mild (J:8936)

Mouse Models of Human Disease
OMIM ID Ref(s)
Atransferrinemia 209300 J:8936 , J:64456





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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory