Phenotypes associated with this allele
Allelic
Composition |
f/f
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Genetic
Background |
FL/1ReJ
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
f mutation
(4 available);
any
f mutation
(4 available)
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hematopoietic system
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• peak numbers of embryonic erythroid colony forming units only about 50% normal numbers in the liver
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• although red cell counts are significantly reduced at birth they achieve near normal levels by 7 days of age
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• at birth the hematocrit is significantly lower (31.5 versus 43.4 in controls) but hematocrit reaches normal levles by 7 days of age
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• significantly smaller volumes at birth but normal by 7 days of age
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homeostasis/metabolism
growth/size/body
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• slight reduction in body weight from birth through 60 days of age in both males and females
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pigmentation
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• white pigment covers an average of 22.9% and 23.6% of the ventrum in females and males respectively
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integument
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• white pigment covers an average of 22.9% and 23.6% of the ventrum in females and males respectively
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Allelic
Composition |
f/f
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Genetic
Background |
involves: CBA/St |
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
f mutation
(4 available);
any
f mutation
(4 available)
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mortality/aging
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• early postnatal depletion of homozygous animals
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hematopoietic system
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• first evident at embryonic day 12
(J:14979)
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• although the mean red blood cell size is normal, the hemoglobin concentration is reduced, there are fewer red blood cells and this transitory anemia is most significant embryonically and at birth then wanes during the first few weeks of life
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• the majority of red blood cells in newborns are siderocytes, which are incompletely haemoglobinized as evidenced by faint color and weak stain uptake
• the percentage of siderocytes decreases from 80% at birth to approximately 40% at 1 week of age and stabilizes at approximately 3% by 3 weeks of age persisting at this higher than normal level in the adult
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• striking reticulocytosis at birth and reticulocyte count remains high at 13 days of age but decreases by 3 weeks of age as the anemia resolves
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integument
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• homozygotes are recognizably paler than normal from embryonic day 16 onward and most can be identified this way as early as embryonic day 15
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Allelic
Composition |
f/f
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Genetic
Background |
Not Specified |
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
f mutation
(4 available);
any
f mutation
(4 available)
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mortality/aging
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• death rate in the first 3 to 4 weeks after birth is about 4 times normal
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limbs/digits/tail
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• flexure due to unilateral fusions of successive vertebrae
• first appears around E14
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• 1-5 permanent angles in tail
• sometimes curves and spirals instead of sharp angles
• tails can occasionally be nearly normal
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skeleton
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• abnormal development
• fibrous pad sometimes fails to develop or does not develop on one side
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• fusions seen in caudal vertebrae also seen throughout the vertebral column
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• flexure due to unilateral fusions of successive vertebrae
• first appears around E14
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hematopoietic system
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• delayed maturation of committed erythroid stem cells
• adults with a poor response to hemopoietic stress
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• anemia at E14 through birth
(J:13090)
• hematopoesis problem in the liver
(J:13090)
• anemia becomes less severe after E16 when hematopoetic function of bone marrow begins
(J:13090)
• recovery from anemia in the first 2 weeks of life
(J:13090)
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• transitory hypochromic and microcytic anemia
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• reduced RBC counts from E14 through birth
• adult RBC counts are normal
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homeostasis/metabolism
growth/size/body
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• sometimes there is a dorsal enlargement of the head in front of the ears
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• smaller size at birth and through adulthood
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vision/eye
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• one or both eyes sometimes remain closed
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pigmentation
embryo
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• a minority of homozygotes assessed during embryonic development are found to have irregular lumen shape, longitudinal waves or angles of the tube, or locally doubled neural tube
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• a minority of homozygotes assessed during embryonic development are found to have ventral swelling of the notochord, dorsal projections, bifurcate notochord, or other morphological abnormalities in the notochord
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nervous system
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• a minority of homozygotes assessed during embryonic development are found to have irregular lumen shape, longitudinal waves or angles of the tube, or locally doubled neural tube
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integument
growth/size/body
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• although slightly reduced in body weight relative to controls this is less severe than in flexed-tail homozygotes wildtype at the Kit locus
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hematopoietic system
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• the reduction in erythrocyte cell number at birth is less severe than in flex-tail homozygotes that are wildtype at the Kit locus and by 7 days of age the count is higher than normal and this persists
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• decreased at birth, but closer to normal values than in flexed-tail homozgyotes that are wildtype at the Kit locus
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• from birth onward more severe decrease in erythrocyte volume than in flexed-tail homozygotes wildtype at the Kit locus
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pigmentation
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• the amount of white pigmentation is greater than the sum of the white pigmentation of the distinct mutants, with females having an average of 54.7% white on the ventrum and males having an average of 59.7%
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integument
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• the amount of white pigmentation is greater than the sum of the white pigmentation of the distinct mutants, with females having an average of 54.7% white on the ventrum and males having an average of 59.7%
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pigmentation
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• white pigment covers an average of 22% and 27.5% of the ventrum in females and males respectively
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integument
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• white pigment covers an average of 22% and 27.5% of the ventrum in females and males respectively
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immune system
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• although the rate and extent of mast cell degranulation when triggered by GTPgammaS is not significantly abnormal, the cell membrane capacitance changes of mast cells, reflective of exoctyosis, show approximately three times more transient fusion events than normal and the dwell time of the transient fusion events is increased
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hematopoietic system
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• although the rate and extent of mast cell degranulation when triggered by GTPgammaS is not significantly abnormal, the cell membrane capacitance changes of mast cells, reflective of exoctyosis, show approximately three times more transient fusion events than normal and the dwell time of the transient fusion events is increased
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cellular
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• although the rate and extent of mast cell degranulation when triggered by GTPgammaS is not significantly abnormal, the cell membrane capacitance changes of mast cells, reflective of exoctyosis, show approximately three times more transient fusion events than normal and the dwell time of the transient fusion events is increased
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