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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tgcog
congenital goiter
MGI:1856829
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Tgcog/Tgcog AKR/J-Tgcog MGI:3032546
hm2
Tgcog/Tgcog involves: AKR/J * C57BL/6By MGI:3032571


Genotype
MGI:3032546
hm1
Allelic
Composition
Tgcog/Tgcog
Genetic
Background
AKR/J-Tgcog
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tgcog mutation (2 available); any Tg mutation (146 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands
• obliteration of most follicular lumens
• small numbers of lymphocytes in degenerating follicles
• hypertrophy and hyperplasia of thyrofollicular cells
• reduced when diet supplemented with desiccated thyroid powder

growth/size/body
• evident at day 15 postnatal
• repaired when diet supplemented with desiccated thyroid powder
• evident between 4 and 7 weeks of age

homeostasis/metabolism
• serum thyroxine is significantly reduced




Genotype
MGI:3032571
hm2
Allelic
Composition
Tgcog/Tgcog
Genetic
Background
involves: AKR/J * C57BL/6By
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tgcog mutation (2 available); any Tg mutation (146 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands
• hypertrophy of thyrofollicular cells

growth/size/body
• evident at day 15 postnatal (J:3079)
• evident by 15 days postnatal (J:8567)
• repaired when diet at weaning was supplemented with desiccated thyroid powder (J:8567)

hematopoietic system

homeostasis/metabolism

nervous system
• cerebrum and cerebellum weighed significantly less than littermate controls
• brain stem weight equivalent to littermate controls
• hypomyelination, restricted to cerebrum

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
congenital hypothyroidism DOID:0050328 OMIM:PS275200
J:8567





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory