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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
4930453N24Rikdin
dense incisors
MGI:1856802
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
4930453N24Rikdin/4930453N24Rikdin B6C3Fe a/a-4930453N24Rikdin/J MGI:3047683


Genotype
MGI:3047683
hm1
Allelic
Composition
4930453N24Rikdin/4930453N24Rikdin
Genetic
Background
B6C3Fe a/a-4930453N24Rikdin/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
4930453N24Rikdin mutation (1 available); any 4930453N24Rik mutation (4 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• most die before 5 months of age

skeleton
• continued dentin formation after arrested incisor eruption occludes pulp chamber creating a dense incisor
• incisors begin to erupt but cease erupting after initial penetration of the oral epithelium
• molar eruption is unaffected
• incisors show increased dentin thickness in older mice
• continued dentin formation after arrested tooth eruption occludes pulp chamber creating a dense incisor
• failure of continued incisor eruption produces an open bite anteriorly, rendering these teeth useless for chewing and gnawing

pigmentation
• the ventral coat is lighter resembling at or Aw;white feet and tail tip observed; yellow hair absent from ears
• abnormal dorsoventral pigment pattern resembles at and Aw

craniofacial
• continued dentin formation after arrested incisor eruption occludes pulp chamber creating a dense incisor
• incisors begin to erupt but cease erupting after initial penetration of the oral epithelium
• molar eruption is unaffected
• incisors show increased dentin thickness in older mice
• continued dentin formation after arrested tooth eruption occludes pulp chamber creating a dense incisor
• failure of continued incisor eruption produces an open bite anteriorly, rendering these teeth useless for chewing and gnawing

growth/size/body
• continued dentin formation after arrested incisor eruption occludes pulp chamber creating a dense incisor
• incisors begin to erupt but cease erupting after initial penetration of the oral epithelium
• molar eruption is unaffected
• incisors show increased dentin thickness in older mice
• continued dentin formation after arrested tooth eruption occludes pulp chamber creating a dense incisor
• failure of continued incisor eruption produces an open bite anteriorly, rendering these teeth useless for chewing and gnawing
• mean body weight increasingly differs from normal littermates after the first postnatal week and is not caused by abnormal dentition

hearing/vestibular/ear

integument
• the ventral coat is lighter resembling at or Aw;white feet and tail tip observed; yellow hair absent from ears
• abnormal dorsoventral pigment pattern resembles at and Aw





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/11/2020
MGI 6.14
The Jackson Laboratory