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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Ay
agouti yellow
MGI:1856798
Summary 40 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Ay/Ay 101-Ay MGI:5140011
ht2
Ay/Aw 129S1.C3-Ay/Aw Chr 19MOLF/Ei MGI:3838978
ht3
Ay/a B6.Cg-Ay/J MGI:3799322
ht4
Ay/A C3HeB/FeJ MGI:5086113
ht5
Ay/A involves: C57BL/6 MGI:3773447
ht6
Ay/a involves: KK MGI:3760281
cx7
Ay/a
Sik2tm1Htake/Sik2+
C57BL/6-Sik2tm1Htake MGI:5609871
cx8
Ay/a
Npbwr1tm1Rck/Npbwr1tm1Rck
involves: 129P/Ola * C57BL/6J MGI:3526898
cx9
Ay/a
Apoetm1Unc/Apoetm1Unc
involves: 129P2/OlaHsd * C57BL/6J * KK/TaJcl MGI:5297860
cx10
Ay/a
Apoetm1Unc/Apoetm1Unc
Ccr2tm1Mae/Ccr2tm1Mae
involves: 129P2/OlaHsd * C57BL/6J * KK/TaJcl MGI:5297861
cx11
Ay/a
Agrptm2(DTR)Rpa/Agrp+
involves: 129S4/SvJaeSor * KK/Upj MGI:3776093
cx12
Ay/A
Pepddal/Pepddal
involves: C3H/HeJ * CBA/J MGI:5605663
cx13
Ay/A
Prkar2btm2Gsm/Prkar2btm2Gsm
involves: C57BL/6 MGI:3773448
cx14
Ay/A
Prkar2btm2Gsm/Prkar2b+
involves: C57BL/6 MGI:3773449
cx15
Ay/a
Rmi1Gt(pUHachi)0283Imeg/Rmi1+
involves: C57BL/6 * KK MGI:4936833
cx16
a/Ay
Zc3h4KK/Zc3h4KK
involves: C57BL/6J * KK-Ay MGI:2679980
cx17
a/Ay
Zc3h4C57BL/6J/Zc3h4KK
involves: C57BL/6J * KK-Ay MGI:2679981
cx18
a/Ay
Bwq2KK/Bwq2KK
involves: C57BL/6J * KK-Ay MGI:3487268
cx19
a/Ay
Bwq10C57BL/6J/Bwq10C57BL/6J
involves: C57BL/6J * KK-Ay MGI:3773901
cx20
a/Ay
Guq1KK/Guq1KK
involves: C57BL/6J * KK-Ay MGI:3773902
cx21
a/Ay
Guq2C57BL/6J/Guq2C57BL/6J
involves: C57BL/6J * KK-Ay MGI:3773903
cx22
Ay/a
Mssq1KK/TaJcl/?
involves: C57BL/6JJcl * KK/TaJcl MGI:3833436
cx23
Ay/a
Mssq2C57BL/6JJcl/Mssq2KK/TaJcl
involves: C57BL/6JJcl * KK/TaJcl MGI:3833439
cx24
Ay/a
Mssq3KK/TaJcl/?
involves: C57BL/6JJcl * KK/TaJcl MGI:3833448
cx25
Ay/a
Mssq4KK/TaJcl/?
involves: C57BL/6JJcl * KK/TaJcl MGI:3833452
cx26
Ay/a
Mssq5C57BL/6JJcl/?
involves: C57BL/6JJcl * KK/TaJcl MGI:3833454
cx27
Ay/a
Mssq6C57BL/6JJcl/?
involves: C57BL/6JJcl * KK/TaJcl MGI:3833456
cx28
Ay/a
Mssq6KK/TaJcl/?
involves: C57BL/6JJcl * KK/TaJcl MGI:3833460
cx29
Ay/a
Mssq7KK/TaJcl/?
involves: C57BL/6JJcl * KK/TaJcl MGI:3833471
cx30
Ay/a
Mssq9C57BL/6JJcl/?
involves: C57BL/6JJcl * KK/TaJcl MGI:3833969
cx31
Ay/a
Mssq10KK/TaJcl/?
involves: C57BL/6JJcl * KK/TaJcl MGI:3833971
cx32
Ay/a
Mssq11KK/TaJcl/?
involves: C57BL/6JJcl * KK/TaJcl MGI:3833973
cx33
Ay/a
Mssq12KK/TaJcl/?
involves: C57BL/6JJcl * KK/TaJcl MGI:3833975
cx34
Ay/a
Mssq13KK/TaJcl/?
involves: C57BL/6JJcl * KK/TaJcl MGI:3833977
cx35
Ay/a
Mssq13C57BL/6JJcl/?
involves: C57BL/6JJcl * KK/TaJcl MGI:3833979
cx36
Ay/a
Mssq14KK/TaJcl/?
involves: C57BL/6JJcl * KK/TaJcl MGI:3833981
cx37
Ay/a
Mssq16KK/TaJcl/?
involves: C57BL/6JJcl * KK/TaJcl MGI:3833984
cx38
Ay/a
Dmbx1tm1Sse/Dmbx1tm1Sse
involves: ICR MGI:3759412
cx39
Ay/a
Tyrp1B-lt/?
Not Specified MGI:3795189
cx40
Ay/a
Ednrbs/Ednrbs
Not Specified MGI:5086233


Genotype
MGI:5140011
hm1
Allelic
Composition
Ay/Ay
Genetic
Background
101-Ay
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ay mutation (10 available); any a mutation (364 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• putative homozygous embryos appear as small masses of vacuolated cells in decidual crypts at the time normal embryos are implanting; the abnormal embryo is resorbed within 36 hours
• Background Sensitivity: the genotype of the mother, with or without Ay, determines if a homozygous embryo dies at the initial stage of implantation or after the process begins

other phenotype
• introducing homozygous Ay embryos into the uterus of a wild-type mouse delays embryonic death until after implantation begins
• there are approximately twice the number of cells, development of a small ectoplacental cone and Reichert's membrane, and disintegration of the decidual epithelium characteristic of an advanced implantation site




Genotype
MGI:3838978
ht2
Allelic
Composition
Ay/Aw
Genetic
Background
129S1.C3-Ay/Aw Chr 19MOLF/Ei
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Aw mutation (17 available); any a mutation (364 available)
Ay mutation (10 available); any a mutation (364 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
tumorigenesis
• incidence of testicular germ cell tumors is decreased 24% compared to in 129S1/SvImJ-Chr 19/Na mice

growth/size/body




Genotype
MGI:3799322
ht3
Allelic
Composition
Ay/a
Genetic
Background
B6.Cg-Ay/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
a mutation (178 available); any a mutation (364 available)
Ay mutation (10 available); any a mutation (364 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Ay/a mouse

behavior/neurological
• the stress of isolation, restraint, or ip injection inhibits feeding

pigmentation
• tyrosinase levels in hairbulb melanocytes ,as determined by 35S methionine incorporation and immunotitration, are reduced in comparison to a/a controls
• decreased tyrosinase suggests the production of predominantly phaeomelanin (yellow)

integument
• tyrosinase levels in hairbulb melanocytes ,as determined by 35S methionine incorporation and immunotitration, are reduced in comparison to a/a controls
• decreased tyrosinase suggests the production of predominantly phaeomelanin (yellow)




Genotype
MGI:5086113
ht4
Allelic
Composition
Ay/A
Genetic
Background
C3HeB/FeJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
A mutation (23 available); any a mutation (364 available)
Ay mutation (10 available); any a mutation (364 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
integument

pigmentation




Genotype
MGI:3773447
ht5
Allelic
Composition
Ay/A
Genetic
Background
involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
A mutation (23 available); any a mutation (364 available)
Ay mutation (10 available); any a mutation (364 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
adipose tissue
• female mice have a 6-fold gain in weight of BAT compared to littermate controls
• female mice have almost a 7-fold gain in weight of fat pad
• female mice have a greater than 6-fold gain in weight of fat pad
• female mice have almost a 6-fold gain in weight of fat pad
• female mice have almost a 4-fold gain in percentage of body fat compared to littermate controls
• male mice have almost a 1.8-fold gain in percentage of body fat compared to littermate controls

behavior/neurological
• 18 week old mice eat about 1.4 times more food during a 7 day period compared to wild-type controls
• the locomotor activity of mice is about half that of wild-type mice

growth/size/body
• by 23 weeks of age, female mice have almost double the weight compared to their wild-type littermate controls
• female but not male mice have a significant 5% increase in their body length
• mice gain weight at a greater rate than littermate controls starting at six weeks of age

homeostasis/metabolism
• circulating levels of leptin are over 12-fold higher compared to littermate controls

liver/biliary system
• female mice have almost a 2-fold gain in weight of the liver

pigmentation
• mice have a yellow coat color

integument
• mice have a yellow coat color

Mouse Models of Human Disease
OMIM ID Ref(s)
Obesity 601665 J:131039




Genotype
MGI:3760281
ht6
Allelic
Composition
Ay/a
Genetic
Background
involves: KK
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
a mutation (178 available); any a mutation (364 available)
Ay mutation (10 available); any a mutation (364 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• blood glucose levels increase with age in both sexes
• marked hyperglycemia (400-500 mg/dl) develops by 16 weeks of age
• markedly elevated plasma immunoreactive insulin (IRI) level increases with age
• present at all ages tested (5, 10, 16 weeks) and in both sexes
• insulin sensitivity is impaired at 10 weeks and lost by 16 weeks
• lipogenesis from acetate is elevated at 5 weeks of age, the enhanced activity is maintained until 16 weeks of age
• the acetate/glucose ratio is higher than control in young mice

adipose tissue
• adipose tissue weight increases with age, reaching a maximum at 10 weeks of age

growth/size/body
• greater body weight gain occurs in females as compared to black KK controls

endocrine/exocrine glands
• islets are hypertrophic in 10-16 week old mice
• central cavity formation with occasional red blood cells is observed in islets
• beta cells are degranulated
• degranulated islets are infiltrated with fine glycogen granules

renal/urinary system
• present at all ages tested (5, 10, 16 weeks) and in both sexes
• basement membrane of Bowman's capsules is thickened
• some glomeruli exhibit an accumulation of eosinophilic material in the outer parts of the capillary
• mesangial matrix is thickened
• hyaline materials or hyaline cast is present in tubules
• basement membrane of tubules is thickened
• hyaline materials or hyaline cast is present in tubules

Mouse Models of Human Disease
OMIM ID Ref(s)
Diabetes Mellitus, Noninsulin-Dependent; NIDDM 125853 J:26460




Genotype
MGI:5609871
cx7
Allelic
Composition
Ay/a
Sik2tm1Htake/Sik2+
Genetic
Background
C57BL/6-Sik2tm1Htake
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
a mutation (178 available); any a mutation (364 available)
Ay mutation (10 available); any a mutation (364 available)
Sik2tm1Htake mutation (0 available); any Sik2 mutation (15 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
integument
• slightly darker than in Ay/a mice on the dorsal region
• darker ventral region hair compared with Ay/a mice

pigmentation
• slightly darker than in Ay/a mice on the dorsal region
• darker ventral region hair compared with Ay/a mice




Genotype
MGI:3526898
cx8
Allelic
Composition
Ay/a
Npbwr1tm1Rck/Npbwr1tm1Rck
Genetic
Background
involves: 129P/Ola * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
a mutation (178 available); any a mutation (364 available)
Ay mutation (10 available); any a mutation (364 available)
Npbwr1tm1Rck mutation (0 available); any Npbwr1 mutation (10 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
• male double homozygotes were more obese than heterozygous Ay males whereas females weighted the same as heterozygous Ay females




Genotype
MGI:5297860
cx9
Allelic
Composition
Ay/a
Apoetm1Unc/Apoetm1Unc
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6J * KK/TaJcl
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
a mutation (178 available); any a mutation (364 available)
Apoetm1Unc mutation (22 available); any Apoe mutation (68 available)
Ay mutation (10 available); any a mutation (364 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• mutants develop larger atherosclerotic plaques than a/a Apoetm1Unc/Apoetm1Unc mice
• plaques contain a higher proportion of macrophage infiltration

growth/size/body
• mutants exhibit increased weight gain, despite similar food intake as controls

hematopoietic system
• increase in the proportion of inflammatory monocytes in the blood, liver, muscle, and kidney, but not epididymal fat pads

homeostasis/metabolism

immune system
• increase in the proportion of inflammatory monocytes in the blood, liver, muscle, and kidney, but not epididymal fat pads
• increase in systemic inflammation

renal/urinary system
• mutants develop features of diabetic nephropathy
• mutants exhibit mesangial expansion as indicated by glycogen deposition in the glomeruli
• 20-30% of mutants exhibit nodular sclerosis in the kidney




Genotype
MGI:5297861
cx10
Allelic
Composition
Ay/a
Apoetm1Unc/Apoetm1Unc
Ccr2tm1Mae/Ccr2tm1Mae
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6J * KK/TaJcl
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
a mutation (178 available); any a mutation (364 available)
Apoetm1Unc mutation (22 available); any Apoe mutation (68 available)
Ay mutation (10 available); any a mutation (364 available)
Ccr2tm1Mae mutation (2 available); any Ccr2 mutation (10 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
N
• mutants are protected against the metabolic syndrome, atherosclerosis, and diabetic nephropathy that develops in Ay/a Apoetm1Unc double mutants




Genotype
MGI:3776093
cx11
Allelic
Composition
Ay/a
Agrptm2(DTR)Rpa/Agrp+
Genetic
Background
involves: 129S4/SvJaeSor * KK/Upj
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
a mutation (178 available); any a mutation (364 available)
Agrptm2(DTR)Rpa mutation (0 available); any Agrp mutation (10 available)
Ay mutation (10 available); any a mutation (364 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• in mice treated with diptheria toxin (DT) to specifically ablate NPY-expressing cells

growth/size/body
• in mice treated with diptheria toxin (DT) to specifically ablate NPY-expressing cells




Genotype
MGI:5605663
cx12
Allelic
Composition
Ay/A
Pepddal/Pepddal
Genetic
Background
involves: C3H/HeJ * CBA/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
A mutation (23 available); any a mutation (364 available)
Ay mutation (10 available); any a mutation (364 available)
Pepddal mutation (1 available); any Pepd mutation (14 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
integument
• dark-like homozygotes heterozygous for yellow have much darker dorsal hair than mice heterozygous for both mutations, placing dark-like downstream of agouti transcription

pigmentation
• dark-like homozygotes heterozygous for yellow have much darker dorsal hair than mice heterozygous for both mutations, placing dark-like downstream of agouti transcription

growth/size/body
• mice heterozygous for yellow are obese and longer than normal to the same degree regardless of being wild-type or homozygous for dark-like




Genotype
MGI:3773448
cx13
Allelic
Composition
Ay/A
Prkar2btm2Gsm/Prkar2btm2Gsm
Genetic
Background
involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
A mutation (23 available); any a mutation (364 available)
Ay mutation (10 available); any a mutation (364 available)
Prkar2btm2Gsm mutation (1 available); any Prkar2b mutation (12 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
adipose tissue
• female mice have a 2-fold gain in mg of BAT compared to littermate controls
• female mice have almost a 2-fold increase in fat pad weight compared to wild-type controls
• female mice have about a 2-fold increase in fat pad weight compared to wild-type controls
• female mice have about a 2-fold increase in fat pad weight compared to wild-type controls
• female and male mice have a 1.6-fold gain in percentage of body fat compared to littermate controls

behavior/neurological
N
• food consumption and circulating levels of leptin are close to wild-type levels, which is significantly less compared to mice with only the Ay mutant allele
• locomotor activity is about 1.5-fold higher compared to wild-type control mice

growth/size/body
N
• mean body weight and length of 20-23 week old mice is similar to wild-type littermate controls and is less than is observed in mice with only the Ay mutant allele
• weight and percentage of body fat in female mice is higher than in wild-type mice but is significantly lower than is observed in mice with only the Ay mutant allele
• male but not female mice gain weight at a greater rate than littermate controls starting at six weeks of age
• rate of weight gain in male mice is significantly less than in Ay heterozygotes

pigmentation
• mice have a yellow coat color

integument
• mice have a yellow coat color




Genotype
MGI:3773449
cx14
Allelic
Composition
Ay/A
Prkar2btm2Gsm/Prkar2b+
Genetic
Background
involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
A mutation (23 available); any a mutation (364 available)
Ay mutation (10 available); any a mutation (364 available)
Prkar2btm2Gsm mutation (1 available); any Prkar2b mutation (12 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
adipose tissue
• mice have increased percentage of body fat but is 10% less than what is observed in Ay heterozygotes

behavior/neurological
• mice have a higher food consumption but is about 10% less than the amount Ay heterozygotes consume

growth/size/body
• mice have increased rate of weight growth compared to wild-type mice but significantly less than in Ay heterozygotes




Genotype
MGI:4936833
cx15
Allelic
Composition
Ay/a
Rmi1Gt(pUHachi)0283Imeg/Rmi1+
Genetic
Background
involves: C57BL/6 * KK
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
a mutation (178 available); any a mutation (364 available)
Ay mutation (10 available); any a mutation (364 available)
Rmi1Gt(pUHachi)0283Imeg mutation (0 available); any Rmi1 mutation (19 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
• compared with Ay/a mice

homeostasis/metabolism
• compared with Ay/a mice
• compared with Ay/a mice

behavior/neurological
• compared with Ay/a mice

liver/biliary system
• compared with Ay/a mice

adipose tissue
N
• mice exhibit normal intra-abdominal fat




Genotype
MGI:2679980
cx16
Allelic
Composition
a/Ay
Zc3h4KK/Zc3h4KK
Genetic
Background
involves: C57BL/6J * KK-Ay
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
a mutation (178 available); any a mutation (364 available)
Ay mutation (10 available); any a mutation (364 available)
Zc3h4KK mutation (0 available); any Zc3h4 mutation (154 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body




Genotype
MGI:2679981
cx17
Allelic
Composition
a/Ay
Zc3h4C57BL/6J/Zc3h4KK
Genetic
Background
involves: C57BL/6J * KK-Ay
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
a mutation (178 available); any a mutation (364 available)
Ay mutation (10 available); any a mutation (364 available)
Zc3h4C57BL/6J mutation (0 available); any Zc3h4 mutation (154 available)
Zc3h4KK mutation (0 available); any Zc3h4 mutation (154 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
• increased body weight




Genotype
MGI:3487268
cx18
Allelic
Composition
a/Ay
Bwq2KK/Bwq2KK
Genetic
Background
involves: C57BL/6J * KK-Ay
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
a mutation (178 available); any a mutation (364 available)
Ay mutation (10 available); any a mutation (364 available)
Bwq2KK mutation (0 available); any Bwq2 mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
• increased body weight at 40-100 days of age (J:93199)
• increased body weight at 40, 50, and 60 days of age (J:131439)
• increased weight gain at 30-40 days of age




Genotype
MGI:3773901
cx19
Allelic
Composition
a/Ay
Bwq10C57BL/6J/Bwq10C57BL/6J
Genetic
Background
involves: C57BL/6J * KK-Ay
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
a mutation (178 available); any a mutation (364 available)
Ay mutation (10 available); any a mutation (364 available)
Bwq10C57BL/6J mutation (0 available); any Bwq10 mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
• increased body weight at 40, 50, and 60 days of age




Genotype
MGI:3773902
cx20
Allelic
Composition
a/Ay
Guq1KK/Guq1KK
Genetic
Background
involves: C57BL/6J * KK-Ay
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
a mutation (178 available); any a mutation (364 available)
Ay mutation (10 available); any a mutation (364 available)
Guq1KK mutation (0 available); any Guq1 mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• increased glucosuria severity at 40 days of age

renal/urinary system
• increased glucosuria severity at 40 days of age




Genotype
MGI:3773903
cx21
Allelic
Composition
a/Ay
Guq2C57BL/6J/Guq2C57BL/6J
Genetic
Background
involves: C57BL/6J * KK-Ay
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
a mutation (178 available); any a mutation (364 available)
Ay mutation (10 available); any a mutation (364 available)
Guq2C57BL/6J mutation (0 available); any Guq2 mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• increased glucosuria severity at 40 days of age

renal/urinary system
• increased glucosuria severity at 40 days of age




Genotype
MGI:3833436
cx22
Allelic
Composition
Ay/a
Mssq1KK/TaJcl/?
Genetic
Background
involves: C57BL/6JJcl * KK/TaJcl
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
a mutation (178 available); any a mutation (364 available)
Ay mutation (10 available); any a mutation (364 available)
Mssq1KK/TaJcl mutation (0 available); any Mssq1 mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
craniofacial
• increased mandible size

skeleton
• increased mandible size




Genotype
MGI:3833439
cx23
Allelic
Composition
Ay/a
Mssq2C57BL/6JJcl/Mssq2KK/TaJcl
Genetic
Background
involves: C57BL/6JJcl * KK/TaJcl
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
a mutation (178 available); any a mutation (364 available)
Ay mutation (10 available); any a mutation (364 available)
Mssq2C57BL/6JJcl mutation (0 available); any Mssq2 mutation (0 available)
Mssq2KK/TaJcl mutation (0 available); any Mssq2 mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
craniofacial
• increased mandible size

skeleton
• increased mandible size




Genotype
MGI:3833448
cx24
Allelic
Composition
Ay/a
Mssq3KK/TaJcl/?
Genetic
Background
involves: C57BL/6JJcl * KK/TaJcl
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
a mutation (178 available); any a mutation (364 available)
Ay mutation (10 available); any a mutation (364 available)
Mssq3KK/TaJcl mutation (0 available); any Mssq3 mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
craniofacial
• increased mandible size

skeleton
• increased mandible size




Genotype
MGI:3833452
cx25
Allelic
Composition
Ay/a
Mssq4KK/TaJcl/?
Genetic
Background
involves: C57BL/6JJcl * KK/TaJcl
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
a mutation (178 available); any a mutation (364 available)
Ay mutation (10 available); any a mutation (364 available)
Mssq4KK/TaJcl mutation (0 available); any Mssq4 mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
craniofacial
• increased mandible size

skeleton
• increased mandible size




Genotype
MGI:3833454
cx26
Allelic
Composition
Ay/a
Mssq5C57BL/6JJcl/?
Genetic
Background
involves: C57BL/6JJcl * KK/TaJcl
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
a mutation (178 available); any a mutation (364 available)
Ay mutation (10 available); any a mutation (364 available)
Mssq5C57BL/6JJcl mutation (0 available); any Mssq5 mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
craniofacial
• increased mandible size

skeleton
• increased mandible size




Genotype
MGI:3833456
cx27
Allelic
Composition
Ay/a
Mssq6C57BL/6JJcl/?
Genetic
Background
involves: C57BL/6JJcl * KK/TaJcl
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
a mutation (178 available); any a mutation (364 available)
Ay mutation (10 available); any a mutation (364 available)
Mssq6C57BL/6JJcl mutation (0 available); any Mssq6 mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
craniofacial
• increased values for principal component analysis of mandible size

skeleton
• increased values for principal component analysis of mandible size




Genotype
MGI:3833460
cx28
Allelic
Composition
Ay/a
Mssq6KK/TaJcl/?
Genetic
Background
involves: C57BL/6JJcl * KK/TaJcl
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
a mutation (178 available); any a mutation (364 available)
Ay mutation (10 available); any a mutation (364 available)
Mssq6KK/TaJcl mutation (0 available); any Mssq6 mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
craniofacial
• increased mandible size

skeleton
• increased mandible size




Genotype
MGI:3833471
cx29
Allelic
Composition
Ay/a
Mssq7KK/TaJcl/?
Genetic
Background
involves: C57BL/6JJcl * KK/TaJcl
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
a mutation (178 available); any a mutation (364 available)
Ay mutation (10 available); any a mutation (364 available)
Mssq7KK/TaJcl mutation (0 available); any Mssq7 mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
craniofacial
• increased mandible size

skeleton
• increased mandible size




Genotype
MGI:3833969
cx30
Allelic
Composition
Ay/a
Mssq9C57BL/6JJcl/?
Genetic
Background
involves: C57BL/6JJcl * KK/TaJcl
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
a mutation (178 available); any a mutation (364 available)
Ay mutation (10 available); any a mutation (364 available)
Mssq9C57BL/6JJcl mutation (0 available); any Mssq9 mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
craniofacial
• increased mandible size

skeleton
• increased mandible size




Genotype
MGI:3833971
cx31
Allelic
Composition
Ay/a
Mssq10KK/TaJcl/?
Genetic
Background
involves: C57BL/6JJcl * KK/TaJcl
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
a mutation (178 available); any a mutation (364 available)
Ay mutation (10 available); any a mutation (364 available)
Mssq10KK/TaJcl mutation (0 available); any Mssq10 mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
craniofacial
• increased mandible size

skeleton
• increased mandible size




Genotype
MGI:3833973
cx32
Allelic
Composition
Ay/a
Mssq11KK/TaJcl/?
Genetic
Background
involves: C57BL/6JJcl * KK/TaJcl
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
a mutation (178 available); any a mutation (364 available)
Ay mutation (10 available); any a mutation (364 available)
Mssq11KK/TaJcl mutation (0 available); any Mssq11 mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
craniofacial
• increased values for principal component analysis of mandible size measurements

skeleton
• increased values for principal component analysis of mandible size measurements




Genotype
MGI:3833975
cx33
Allelic
Composition
Ay/a
Mssq12KK/TaJcl/?
Genetic
Background
involves: C57BL/6JJcl * KK/TaJcl
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
a mutation (178 available); any a mutation (364 available)
Ay mutation (10 available); any a mutation (364 available)
Mssq12KK/TaJcl mutation (0 available); any Mssq12 mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
craniofacial
• increased values for principal component analysis of mandible size measurements

skeleton
• increased values for principal component analysis of mandible size measurements




Genotype
MGI:3833977
cx34
Allelic
Composition
Ay/a
Mssq13KK/TaJcl/?
Genetic
Background
involves: C57BL/6JJcl * KK/TaJcl
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
a mutation (178 available); any a mutation (364 available)
Ay mutation (10 available); any a mutation (364 available)
Mssq13KK/TaJcl mutation (0 available); any Mssq13 mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
craniofacial
• increased values for principal component analysis of mandible size measurements

skeleton
• increased values for principal component analysis of mandible size measurements




Genotype
MGI:3833979
cx35
Allelic
Composition
Ay/a
Mssq13C57BL/6JJcl/?
Genetic
Background
involves: C57BL/6JJcl * KK/TaJcl
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
a mutation (178 available); any a mutation (364 available)
Ay mutation (10 available); any a mutation (364 available)
Mssq13C57BL/6JJcl mutation (0 available); any Mssq13 mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
craniofacial
• increased mandible size

skeleton
• increased mandible size




Genotype
MGI:3833981
cx36
Allelic
Composition
Ay/a
Mssq14KK/TaJcl/?
Genetic
Background
involves: C57BL/6JJcl * KK/TaJcl
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
a mutation (178 available); any a mutation (364 available)
Ay mutation (10 available); any a mutation (364 available)
Mssq14KK/TaJcl mutation (0 available); any Mssq14 mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
craniofacial
• increased mandible size
• increased values for principal component analysis of mandible size measurements

skeleton
• increased mandible size
• increased values for principal component analysis of mandible size measurements




Genotype
MGI:3833984
cx37
Allelic
Composition
Ay/a
Mssq16KK/TaJcl/?
Genetic
Background
involves: C57BL/6JJcl * KK/TaJcl
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
a mutation (178 available); any a mutation (364 available)
Ay mutation (10 available); any a mutation (364 available)
Mssq16KK/TaJcl mutation (0 available); any Mssq16 mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
craniofacial
• increased mandible size

skeleton
• increased mandible size




Genotype
MGI:3759412
cx38
Allelic
Composition
Ay/a
Dmbx1tm1Sse/Dmbx1tm1Sse
Genetic
Background
involves: ICR
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
a mutation (178 available); any a mutation (364 available)
Ay mutation (10 available); any a mutation (364 available)
Dmbx1tm1Sse mutation (0 available); any Dmbx1 mutation (9 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
• unlike Ay/a mice, the body weight of double homozygotes is similar to that of Dmbx1 homozygotes




Genotype
MGI:3795189
cx39
Allelic
Composition
Ay/a
Tyrp1B-lt/?
Genetic
Background
Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
a mutation (178 available); any a mutation (364 available)
Ay mutation (10 available); any a mutation (364 available)
Tyrp1B-lt mutation (4 available); any Tyrp1 mutation (164 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
pigmentation
• the light mutation does not seem to impact the yellow phenotype since the coat color of mice without the light mutation is the same yellow coat color as that found in mice carrying at least one copy of the light mutation

integument
• the light mutation does not seem to impact the yellow phenotype since the coat color of mice without the light mutation is the same yellow coat color as that found in mice carrying at least one copy of the light mutation




Genotype
MGI:5086233
cx40
Allelic
Composition
Ay/a
Ednrbs/Ednrbs
Genetic
Background
Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
a mutation (178 available); any a mutation (364 available)
Ay mutation (10 available); any a mutation (364 available)
Ednrbs mutation (26 available); any Ednrb mutation (72 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
integument
• less white spotting is seen in mice of this genotype than in mice without Ay
• a modifier of the amount of white spotting in heterozygous Kit mice was determined to reduce white spotting in heterozygous Ay mice

pigmentation
• less white spotting is seen in mice of this genotype than in mice without Ay
• a modifier of the amount of white spotting in heterozygous Kit mice was determined to reduce white spotting in heterozygous Ay mice





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last database update
04/19/2016
MGI 6.03
The Jackson Laboratory