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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Mlphln
leaden
MGI:1856674
Summary 9 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Mlphln/Mlphln B6.Cg-Sgk3fz H54 Mlphln/+ H54 +/J MGI:3817194
hm2
Mlphln/Mlphln C57BR MGI:2680053
cx3
Mlphln/Mlphln
Sgk3fz/Sgk3fz
C57BL/6J-Sgk3fz Mlphln MGI:3804905
cx4
a/a
Mlphln/Mlphln
Tyrp1b/Tyrp1b
C57L/J MGI:3052536
cx5
a/a
Mlphln/Mlphln
involves: C57BL/J * C57BR MGI:4454435
cx6
Mlphln/Mlphln
Mregdsu/Mregdsu
involves: C57BR MGI:3768124
cx7
l1Rk3/Mlphln involves: C57L/J MGI:2680054
cx8
Mc1re/Mc1re
Mlphln/Mlphln
Not Specified MGI:3689357
cx9
a/a
Mlphln/Mlphln
Not Specified MGI:5468335


Genotype
MGI:3817194
hm1
Allelic
Composition
Mlphln/Mlphln
Genetic
Background
B6.Cg-Sgk3fz H54 Mlphln/+ H54 +/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mlphln mutation (6 available); any Mlph mutation (24 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
pigmentation
N
• mice exhibit wild-type iris pigmentation




Genotype
MGI:2680053
hm2
Allelic
Composition
Mlphln/Mlphln
Genetic
Background
C57BR
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mlphln mutation (6 available); any Mlph mutation (24 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
pigmentation
• melanin synthesis is normal but melanosomes transport is impaired resulting in a "leaden" coat color

integument
• melanin synthesis is normal but melanosomes transport is impaired resulting in a "leaden" coat color




Genotype
MGI:3804905
cx3
Allelic
Composition
Mlphln/Mlphln
Sgk3fz/Sgk3fz
Genetic
Background
C57BL/6J-Sgk3fz Mlphln
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mlphln mutation (6 available); any Mlph mutation (24 available)
Sgk3fz mutation (3 available); any Sgk3 mutation (23 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• bleed time of 0.7 minutes after tail nick is significantly less than the 3.8 minutes in C57BL/6J controls




Genotype
MGI:3052536
cx4
Allelic
Composition
a/a
Mlphln/Mlphln
Tyrp1b/Tyrp1b
Genetic
Background
C57L/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
a mutation (229 available); any a mutation (460 available)
Mlphln mutation (6 available); any Mlph mutation (24 available)
Tyrp1b mutation (29 available); any Tyrp1 mutation (144 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
pigmentation
• due to clumping of pigment
• results in clumping rather than even distribution of pigment during hair development

integument
• due to clumping of pigment




Genotype
MGI:4454435
cx5
Allelic
Composition
a/a
Mlphln/Mlphln
Genetic
Background
involves: C57BL/J * C57BR
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
a mutation (229 available); any a mutation (460 available)
Mlphln mutation (6 available); any Mlph mutation (24 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
pigmentation
• mice have clumped granules in the hair and skin
• granules tend to clump in the choroid but not in the retina

vision/eye
• granules tend to clump in the choroid but not in the retina

integument
• mice have clumped granules in the hair and skin




Genotype
MGI:3768124
cx6
Allelic
Composition
Mlphln/Mlphln
Mregdsu/Mregdsu
Genetic
Background
involves: C57BR
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mlphln mutation (6 available); any Mlph mutation (24 available)
Mregdsu mutation (1 available); any Mreg mutation (101 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
pigmentation
• diluted coat color caused by the Mlphln allele is partially suppressed

integument
• diluted coat color caused by the Mlphln allele is partially suppressed




Genotype
MGI:2680054
cx7
Allelic
Composition
l1Rk3/Mlphln
Genetic
Background
involves: C57L/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
l1Rk3 mutation (1 available); any l1Rk3 mutation (1 available)
Mlphln mutation (6 available); any Mlph mutation (24 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
pigmentation
• phenotype was described as being similar to the original leaden allele

integument
• phenotype was described as being similar to the original leaden allele




Genotype
MGI:3689357
cx8
Allelic
Composition
Mc1re/Mc1re
Mlphln/Mlphln
Genetic
Background
Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mc1re mutation (4 available); any Mc1r mutation (35 available)
Mlphln mutation (6 available); any Mlph mutation (24 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
pigmentation
• homozygosity for the leaden allele masks the yellow coat color of homozygous mutant Mc1re mice

integument
• homozygosity for the leaden allele masks the yellow coat color of homozygous mutant Mc1re mice




Genotype
MGI:5468335
cx9
Allelic
Composition
a/a
Mlphln/Mlphln
Genetic
Background
Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
a mutation (229 available); any a mutation (460 available)
Mlphln mutation (6 available); any Mlph mutation (24 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
integument
• this genotype is indistinguishable from homozygous nonagouti, Myo5ad mice
• pigment bearing cells have fewer and thinner dendritic processes than wild-type melanocytes
• abnormality of shape results in clumping of melanin granules
• melanin granules are clumped into large masses due to the shape of the melanocytes
• this genotype is indistinguishable from homozygous nonagouti, Myo5ad mice

pigmentation
• this genotype is indistinguishable from homozygous nonagouti, Myo5ad mice
• pigment bearing cells have fewer and thinner dendritic processes than wild-type melanocytes
• abnormality of shape results in clumping of melanin granules
• melanin granules are clumped into large masses due to the shape of the melanocytes
• this genotype is indistinguishable from homozygous nonagouti, Myo5ad mice





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last database update
08/03/2022
MGI 6.21
The Jackson Laboratory