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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Abl1m1
Abelson leukemia oncogene m1
MGI:1856663
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Abl1m1/Abl1m1 B6.129-Abl1m1 MGI:4421544
hm2
Abl1m1/Abl1m1 either: 129S/SvEv-Abl1m1 or (involves: 129S/SvEv * CD-1) or (involves: 129S/SvEv * C57BL/6 * DBA/2) MGI:4357934
hm3
Abl1m1/Abl1m1 involves: 129S/SvEv MGI:4357935
hm4
Abl1m1/Abl1m1 involves: 129S/SvEv * C57BL/6 MGI:4357938
ht5
Abl1m1/Abl1+ involves: 129S/SvEv MGI:4357933


Genotype
MGI:4421544
hm1
Allelic
Composition
Abl1m1/Abl1m1
Genetic
Background
B6.129-Abl1m1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Abl1m1 mutation (1 available); any Abl1 mutation (80 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• about 90% die perinatally




Genotype
MGI:4357934
hm2
Allelic
Composition
Abl1m1/Abl1m1
Genetic
Background
either: 129S/SvEv-Abl1m1 or (involves: 129S/SvEv * CD-1) or (involves: 129S/SvEv * C57BL/6 * DBA/2)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Abl1m1 mutation (1 available); any Abl1 mutation (80 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• animals surviving to weaning are highly susceptible to infection
• only about 15% survive to 6 weeks of age
• homozygous growth and development grossly normal through E17
• 75% of pups die within the first week after birth

growth/size/body
• young pups weigh 30-80% as much as controls
• low body weight persists through life

immune system
• mature B cell population in bone marrow seems unaffected
• mature B cell numbers in peripheral blood and lymph nodes are normal
• depleted by half to 2/3
• severely reduced in number
• depleted by half to 2/3 1n bone marrow
• depletion less severe in the spleen
• pre-B cell numbers normal in newborn spleen but become reduced over time
• somewhat reduced CD4+ and CD8+ cells in peripheral blood
• elevated CD4+ and CD8+ cells in the spleen
• involuted thymi frequently found in mice dead at weaning
• in mice dead at weaning
• small thymus in many newborns
• 1/3 as many cells as in controls
• early thymocyte numbers are sometimes reduced
• round kidney shaped spleens
• cell numbers in new born spleens about 50% of controls
• white pulp depleted in mice showing extreme B cell depletion
• animals surviving to weaning are highly susceptible to infection

skeleton
• slight shortening of the skull

vision/eye
• cataracts often develop
• many born with eyes open
• eyes often become damaged

hematopoietic system
• involuted thymi frequently found in mice dead at weaning
• in mice dead at weaning
• small thymus in many newborns
• 1/3 as many cells as in controls
• early thymocyte numbers are sometimes reduced
• mature B cell population in bone marrow seems unaffected
• mature B cell numbers in peripheral blood and lymph nodes are normal
• depleted by half to 2/3
• severely reduced in number
• depleted by half to 2/3 1n bone marrow
• depletion less severe in the spleen
• pre-B cell numbers normal in newborn spleen but become reduced over time
• somewhat reduced CD4+ and CD8+ cells in peripheral blood
• elevated CD4+ and CD8+ cells in the spleen
• round kidney shaped spleens
• cell numbers in new born spleens about 50% of controls
• white pulp depleted in mice showing extreme B cell depletion

craniofacial
• slight shortening of the skull

endocrine/exocrine glands
• involuted thymi frequently found in mice dead at weaning
• in mice dead at weaning
• small thymus in many newborns
• 1/3 as many cells as in controls
• early thymocyte numbers are sometimes reduced




Genotype
MGI:4357935
hm3
Allelic
Composition
Abl1m1/Abl1m1
Genetic
Background
involves: 129S/SvEv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Abl1m1 mutation (1 available); any Abl1 mutation (80 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• spleen cell response to lipopolysaccharides is about 10% that of controls, correcting for reduced B cell numbers
• reduced spleen response to anti-IgM
• response of peripheral blood cells to lipopolysaccharide is about 38% of control response
• response of peripheral blood cells to "conA" is reduced to about 18% of control response
• severe depletion becomes more common in mutants over 10 weeks of age
• CD43+,B220+ pro-B cells are reduced by 55% in bone marrow at 2 months of age
• 77% of control levels overall
• B220+,IgM+ B cells reduced to about 46% of controls in bone marrow at 2 months of age
• levels reduced overall to 67% of controls
• almost completely depleted in bone marrow at 2 months of age
• overall levels at 63% of controls

hematopoietic system
• severe depletion becomes more common in mutants over 10 weeks of age
• CD43+,B220+ pro-B cells are reduced by 55% in bone marrow at 2 months of age
• 77% of control levels overall
• B220+,IgM+ B cells reduced to about 46% of controls in bone marrow at 2 months of age
• levels reduced overall to 67% of controls
• almost completely depleted in bone marrow at 2 months of age
• overall levels at 63% of controls
• bone marrow cell response to Il7 is elevated in young animals and reduced in older ones
• spleen cell response to lipopolysaccharides is about 10% that of controls, correcting for reduced B cell numbers
• reduced spleen response to anti-IgM




Genotype
MGI:4357938
hm4
Allelic
Composition
Abl1m1/Abl1m1
Genetic
Background
involves: 129S/SvEv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Abl1m1 mutation (1 available); any Abl1 mutation (80 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• common lymphoid progenitors are dramatically reduced in number
• "fraction A" pro-B-cells are dramatically reduced in number
• calcium flux response to CD19 cross linking is absent

hematopoietic system
• common lymphoid progenitors are dramatically reduced in number
• "fraction A" pro-B-cells are dramatically reduced in number
• calcium flux response to CD19 cross linking is absent
• bone marrow cell response to Il7 is elevated




Genotype
MGI:4357933
ht5
Allelic
Composition
Abl1m1/Abl1+
Genetic
Background
involves: 129S/SvEv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Abl1m1 mutation (1 available); any Abl1 mutation (80 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
normal phenotype
• normal growth and development





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
01/18/2022
MGI 6.17
The Jackson Laboratory