Phenotypes associated with this allele

• Allele Symbol: Soat1^ald
• Allele Name: adrenocortical lipid depletion
• Allele ID: MGI:1856648
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Soat1^ald/Soat1^ald	AKR	MGI:3588540
hm2	Soat1^ald/Soat1^ald	AKR/O	MGI:4867512

Genotype
MGI:3588540

hm1

• Allelic Composition: Soat1^ald/Soat1^ald
• Genetic Background: AKR

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

integument

abnormal hair growth ( J:15247 )

• homozygotes can be ascertained only by microscopic examination of the hair

• distal regions of all hair types are especially affected

• all AKR strains are homozygous for this mutation

• morphology and arrangement of medullary cells are abnormal

abnormal hair shaft morphology ( J:15247 )

• medullary cell abnormality effects calibre of hair shaft

abnormal hair medulla ( J:15247 )

• medulla morphology and arrangement are abnormal

• random and tightly packed medullary cells produce irregularities of hair shaft calibre

Genotype
MGI:4867512

hm2

• Allelic Composition: Soat1^ald/Soat1^ald
• Genetic Background: AKR/O

endocrine/exocrine glands

abnormal adrenal cortex morphology ( J:5089 , J:12157 )

• onset of adrenocortical lipid depletion takes place in mice between 30 and 40 days of age (J:5089)

• in males adrenocortical lipid depletion coincides roughly with adrenal X-zone degeneration and maturation of seminiferous epithelium (J:5089)

• adrenal cortex of males is totally depleted of lipid (J:12157)

• adrenal cortex of females is not totally depleted and lipid pattern is variable (J:12157)

• large doses of ACTH restores lipid concentration and distribution (J:12157)

abnormal adrenocortical cell morphology ( J:12157 )

• lipid vacuoles are sparse

• cells are enriched with mitochondria

thymus hyperplasia ( J:12157 )

• evident from birth

hematopoietic system

thymus hyperplasia ( J:12157 )

• evident from birth

immune system

thymus hyperplasia ( J:12157 )

• evident from birth

neoplasm

increased leukemia incidence ( J:12157 )

• high incidence of lymphatic leukemia