Analysis Tools
limbs/digits/tail
|
• hindfeet are severely deformed by 4-6 weeks of age
|
kinked tail
(
J:104476
)
|
• tail kinks evident by 6-8 weeks of age
|
hearing/vestibular/ear
|
• half of older mice develop erythematous, thickened outer ears with evidence of cartilage destruction
|
|
• half of older mice show evidence of cartilage destruction
|
|
• dermis and epidermis of outer ear is infiltrated with an inflammatory mediators including polymorphonuclear cells
• some neutrophilic microabcesses are observed
|
immune system
|
• approximately 1.5 times the size of controls
|
|
• dermis and epidermis of outer ear is infiltrated with an inflammatory mediators including polymorphonuclear cells
• some neutrophilic microabcesses are observed
|
|
• lymph nodes contain large populations of transformed cells with features of immunoblasts
|
|
• tail sections reveal areas of dead bone surrounded by inflammatory infiltrate, predominantly neutrophils
(J:104476)
• spinal and caudal vertebrae are nearly destroyed with a mixed inflammatory infiltrate
(J:105410)
• this phenotype is progressive with age and begins at 3-4 weeks of age in distal vertebrae and develops in proximal vertebrae later
(J:105410)
• no abnormalities are seen in the long bones of the limbs
(J:105410)
|
hematopoietic system
|
• approximately 1.5 times the size of controls
|
|
• evidence of extramedullary hematopoiesis in the red pulp of the spleen; may account for increased size of spleen
|
skeleton
|
• half of older mice show evidence of cartilage destruction
|
|
• tail sections reveal areas of dead bone surrounded by inflammatory infiltrate, predominantly neutrophils
(J:104476)
• spinal and caudal vertebrae are nearly destroyed with a mixed inflammatory infiltrate
(J:105410)
• this phenotype is progressive with age and begins at 3-4 weeks of age in distal vertebrae and develops in proximal vertebrae later
(J:105410)
• no abnormalities are seen in the long bones of the limbs
(J:105410)
|
craniofacial
|
• half of older mice develop erythematous, thickened outer ears with evidence of cartilage destruction
|
|
• half of older mice show evidence of cartilage destruction
|
integument
|
• thickened, dystrophic hind foot nails
|
growth/size/body
|
• half of older mice develop erythematous, thickened outer ears with evidence of cartilage destruction
|
|
• half of older mice show evidence of cartilage destruction
|
|
• approximately 1.5 times the size of controls
|
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| chronic recurrent multifocal osteomyelitis | DOID:0060645 |
OMIM:259680 |
J:104476 , J:105410 | |
