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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Pax6132-14Neu
132-14, Neuherberg
MGI:1856585
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Pax6132-14Neu/Pax6132-14Neu C3.Cg-Pax6132-14Neu MGI:3707321
hm2
Pax6132-14Neu/Pax6132-14Neu involves: 101 * C3H MGI:2175740
ht3
Pax6132-14Neu/Pax6+ C3.Cg-Pax6132-14Neu MGI:3707320
ht4
Pax6132-14Neu/Pax6+ involves: 101 * C3H MGI:2175741


Genotype
MGI:3707321
hm1
Allelic
Composition
Pax6132-14Neu/Pax6132-14Neu
Genetic
Background
C3.Cg-Pax6132-14Neu
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pax6132-14Neu mutation (0 available); any Pax6 mutation (64 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Pax6132-14Neu/Pax6+ and Pax6132-14Neu/Pax6132-14Neu histological adult eye sections.

vision/eye
• the corneal stroma is pierced centrally by a strand of epithelial cells continuous with the corneal epithelium
• the anterior chamber is absent and the small globe is filled with extensively folded but well differentiated retina
• the lens is severely malformed, consisting of small clusters of round fiber-like cells and irregular strands of lens epithelium and capsule
• microphthalmic eyes show a persistent connection between the lens and the cornea
• in some eyes, colobomata occurs at the posterior pole
• the vitreous body is absent




Genotype
MGI:2175740
hm2
Allelic
Composition
Pax6132-14Neu/Pax6132-14Neu
Genetic
Background
involves: 101 * C3H
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pax6132-14Neu mutation (0 available); any Pax6 mutation (64 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
vision/eye
• complete penetrance




Genotype
MGI:3707320
ht3
Allelic
Composition
Pax6132-14Neu/Pax6+
Genetic
Background
C3.Cg-Pax6132-14Neu
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pax6132-14Neu mutation (0 available); any Pax6 mutation (64 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Pax6132-14Neu/Pax6+ and Pax6132-14Neu/Pax6132-14Neu histological adult eye sections.

vision/eye
• fusion of the lens to the cornea is associated with a defect in the corneal stroma and endothelium, which is filled with epithelial cells continuous with those covering the conically projecting anterior surface of the lens
• defect in the corneal stroma, which is filled with epithelial cells
• in the lens, a plaque of multilayered epithelial cells and degenerated cortical fibers underlay the fusion point
• the anterior pole of the lens is fused to the cornea
• failure of lens vesicle to separate from ectoderm
• eyes in which the lens and cornea are separated display an anterior polar cataract and central corneal defect involving the stroma, Descemet's membrane, and endothelium




Genotype
MGI:2175741
ht4
Allelic
Composition
Pax6132-14Neu/Pax6+
Genetic
Background
involves: 101 * C3H
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pax6132-14Neu mutation (0 available); any Pax6 mutation (64 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
vision/eye
• the remnants of the pupillary membrane connect the opacity with the cornea
• failure of lens vesicle to separate from ectoderm
• pyramidal opacity at anterior pole of lens; uni- or bilateral and incomplete penetrance
• the opacity frequently protrudes into the anterior chamber and attaches to the cornea

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
cataract DOID:83 OMIM:601371
J:6686





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/12/2017
MGI 6.10
The Jackson Laboratory