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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Pax6132-14Neu
132-14, Neuherberg
MGI:1856585
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Pax6132-14Neu/Pax6132-14Neu C3.Cg-Pax6132-14Neu MGI:3707321
hm2
Pax6132-14Neu/Pax6132-14Neu involves: 101 * C3H MGI:2175740
ht3
Pax6132-14Neu/Pax6+ C3.Cg-Pax6132-14Neu MGI:3707320
ht4
Pax6132-14Neu/Pax6+ involves: 101 * C3H MGI:2175741


Genotype
MGI:3707321
hm1
Allelic
Composition
Pax6132-14Neu/Pax6132-14Neu
Genetic
Background
C3.Cg-Pax6132-14Neu
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pax6132-14Neu mutation (0 available); any Pax6 mutation (54 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Pax6132-14Neu/Pax6+ and Pax6132-14Neu/Pax6132-14Neu histological adult eye sections.

vision/eye
• the corneal stroma is pierced centrally by a strand of epithelial cells continuous with the corneal epithelium
• the anterior chamber is absent and the small globe is filled with extensively folded but well differentiated retina
• the lens is severely malformed, consisting of small clusters of round fiber-like cells and irregular strands of lens epithelium and capsule
• microphthalmic eyes show a persistent connection between the lens and the cornea
• in some eyes, colobomata occurs at the posterior pole
• the vitreous body is absent




Genotype
MGI:2175740
hm2
Allelic
Composition
Pax6132-14Neu/Pax6132-14Neu
Genetic
Background
involves: 101 * C3H
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pax6132-14Neu mutation (0 available); any Pax6 mutation (54 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
vision/eye
• complete penetrance




Genotype
MGI:3707320
ht3
Allelic
Composition
Pax6132-14Neu/Pax6+
Genetic
Background
C3.Cg-Pax6132-14Neu
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pax6132-14Neu mutation (0 available); any Pax6 mutation (54 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Pax6132-14Neu/Pax6+ and Pax6132-14Neu/Pax6132-14Neu histological adult eye sections.

vision/eye
• fusion of the lens to the cornea is associated with a defect in the corneal stroma and endothelium, which is filled with epithelial cells continuous with those covering the conically projecting anterior surface of the lens
• defect in the corneal stroma, which is filled with epithelial cells
• in the lens, a plaque of multilayered epithelial cells and degenerated cortical fibers underlay the fusion point
• the anterior pole of the lens is fused to the cornea
• failure of lens vesicle to separate from ectoderm
• eyes in which the lens and cornea are separated display an anterior polar cataract and central corneal defect involving the stroma, Descemet's membrane, and endothelium

Mouse Models of Human Disease
OMIM ID Ref(s)
Anterior Segment Mesenchymal Dysgenesis; ASMD 107250 J:40665




Genotype
MGI:2175741
ht4
Allelic
Composition
Pax6132-14Neu/Pax6+
Genetic
Background
involves: 101 * C3H
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pax6132-14Neu mutation (0 available); any Pax6 mutation (54 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
vision/eye
• the remnants of the pupillary membrane connect the opacity with the cornea
• failure of lens vesicle to separate from ectoderm
• pyramidal opacity at anterior pole of lens; uni- or bilateral and incomplete penetrance
• the opacity frequently protrudes into the anterior chamber and attaches to the cornea





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/15/2016
MGI 6.04
The Jackson Laboratory