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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Pax6132-14Neu
132-14, Neuherberg
MGI:1856585
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Pax6132-14Neu/Pax6132-14Neu C3.Cg-Pax6132-14Neu MGI:3707321
hm2
Pax6132-14Neu/Pax6132-14Neu involves: 101 * C3H MGI:2175740
ht3
Pax6132-14Neu/Pax6+ C3.Cg-Pax6132-14Neu MGI:3707320
ht4
Pax6132-14Neu/Pax6+ involves: 101 * C3H MGI:2175741


Genotype
MGI:3707321
hm1
Allelic
Composition
Pax6132-14Neu/Pax6132-14Neu
Genetic
Background
C3.Cg-Pax6132-14Neu
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pax6132-14Neu mutation (0 available); any Pax6 mutation (49 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Pax6132-14Neu/Pax6+ and Pax6132-14Neu/Pax6132-14Neu histological adult eye sections.

vision/eye
• the corneal stroma is pierced centrally by a strand of epithelial cells continuous with the corneal epithelium (J:40665)
• the corneal stroma is pierced centrally by a strand of epithelial cells continuous with the corneal epithelium (J:40665)
• the anterior chamber is absent and the small globe is filled with extensively folded but well differentiated retina (J:40665)
• the anterior chamber is absent and the small globe is filled with extensively folded but well differentiated retina (J:40665)
• the lens is severely malformed, consisting of small clusters of round fiber-like cells and irregular strands of lens epithelium and capsule (J:40665)
• the lens is severely malformed, consisting of small clusters of round fiber-like cells and irregular strands of lens epithelium and capsule (J:40665)
• microphthalmic eyes show a persistent connection between the lens and the cornea (J:40665)
• microphthalmic eyes show a persistent connection between the lens and the cornea (J:40665)
• in some eyes, colobomata occurs at the posterior pole (J:40665)
• in some eyes, colobomata occurs at the posterior pole (J:40665)
• the vitreous body is absent (J:40665)
• the vitreous body is absent (J:40665)




Genotype
MGI:2175740
hm2
Allelic
Composition
Pax6132-14Neu/Pax6132-14Neu
Genetic
Background
involves: 101 * C3H
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pax6132-14Neu mutation (0 available); any Pax6 mutation (49 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
vision/eye
• complete penetrance (J:6686)
• complete penetrance (J:6686)




Genotype
MGI:3707320
ht3
Allelic
Composition
Pax6132-14Neu/Pax6+
Genetic
Background
C3.Cg-Pax6132-14Neu
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pax6132-14Neu mutation (0 available); any Pax6 mutation (49 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Pax6132-14Neu/Pax6+ and Pax6132-14Neu/Pax6132-14Neu histological adult eye sections.

vision/eye
• fusion of the lens to the cornea is associated with a defect in the corneal stroma and endothelium, which is filled with epithelial cells continuous with those covering the conically projecting anterior surface of the lens (J:40665)
• fusion of the lens to the cornea is associated with a defect in the corneal stroma and endothelium, which is filled with epithelial cells continuous with those covering the conically projecting anterior surface of the lens (J:40665)
• defect in the corneal stroma, which is filled with epithelial cells (J:40665)
• defect in the corneal stroma, which is filled with epithelial cells (J:40665)
• in the lens, a plaque of multilayered epithelial cells and degenerated cortical fibers underlay the fusion point (J:40665)
• in the lens, a plaque of multilayered epithelial cells and degenerated cortical fibers underlay the fusion point (J:40665)
• the anterior pole of the lens is fused to the cornea (J:40665)
• the anterior pole of the lens is fused to the cornea (J:40665)
• failure of lens vesicle to separate from ectoderm (J:40665)
• failure of lens vesicle to separate from ectoderm (J:40665)
• eyes in which the lens and cornea are separated display an anterior polar cataract and central corneal defect involving the stroma, Descemet's membrane, and endothelium (J:40665)
• eyes in which the lens and cornea are separated display an anterior polar cataract and central corneal defect involving the stroma, Descemet's membrane, and endothelium (J:40665)

Mouse Models of Human Disease
OMIM ID Ref(s)
Anterior Segment Mesenchymal Dysgenesis; ASMD 107250 J:40665




Genotype
MGI:2175741
ht4
Allelic
Composition
Pax6132-14Neu/Pax6+
Genetic
Background
involves: 101 * C3H
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pax6132-14Neu mutation (0 available); any Pax6 mutation (49 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
vision/eye
• the remnants of the pupillary membrane connect the opacity with the cornea (J:6686)
• the remnants of the pupillary membrane connect the opacity with the cornea (J:6686)
• failure of lens vesicle to separate from ectoderm (J:6686)
• failure of lens vesicle to separate from ectoderm (J:6686)
• pyramidal opacity at anterior pole of lens; uni- or bilateral and incomplete penetrance (J:6686)
• the opacity frequently protrudes into the anterior chamber and attaches to the cornea (J:6686)
• pyramidal opacity at anterior pole of lens; uni- or bilateral and incomplete penetrance (J:6686)
• the opacity frequently protrudes into the anterior chamber and attaches to the cornea (J:6686)





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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory