About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Atcayji
jittery
MGI:1856574
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Atcayji/Atcayji JIGR MGI:3719716
hm2
Atcayji/Atcayji Not Specified MGI:3032441


Genotype
MGI:3719716
hm1
Allelic
Composition
Atcayji/Atcayji
Genetic
Background
JIGR
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atcayji mutation (2 available); any Atcay mutation (18 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mice die at 3 to 4 weeks of dehydration and starvation

behavior/neurological
• severe truncal and limb ataxia
• at 3 weeks mice are unable to walk or to right themselves

homeostasis/metabolism

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
Cayman type cerebellar ataxia DOID:0060694 OMIM:601238
J:85793




Genotype
MGI:3032441
hm2
Allelic
Composition
Atcayji/Atcayji
Genetic
Background
Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atcayji mutation (2 available); any Atcay mutation (18 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• as seizures and impaired coordination become more severe, the mice lose the ability to obtain food and die, usually by 4 weeks old, from starvation and thirst

behavior/neurological
• animals exhibited difficulty righting themselves after being placed on their backs
• progressive impaired coordination beginning at 10 to 16 days of age
• severe muscle tetany was exhibited after the onset of impaired coordination
• seizures become progressively worse with age

endocrine/exocrine glands
• anterior pituitary lobes were congested and hypercellular
• the cortex appears as a mass of stromal cells and an absence of lymphocytes was noted
• the thymic medulla is filled with cell debris and pyknotic nuclei
• thyroid glands appear similar to controls at 11 days of age, but at 33 days of age the colloid is less homogeneous, the secreting cells are abnormally shaped and placed, and the connective tissue displays hyperplasia
• hypoactive thyroid
• involuted thymus glands; involution is first noted coincident with the onset of impaired coordination

immune system
• the cortex appears as a mass of stromal cells and an absence of lymphocytes was noted
• the thymic medulla is filled with cell debris and pyknotic nuclei

muscle
• severe muscle tetany was exhibited after the onset of impaired coordination
• severe muscle tetany was exhibited after the onset of impaired coordination

nervous system
• seizures become progressively worse with age
• anterior pituitary lobes were congested and hypercellular
• polycystic alterations in white matter of the brain were noted
• degeneration of the motor neurons of the lumbar spinal cord was noted; cells appeared vacuolated

hematopoietic system
• the cortex appears as a mass of stromal cells and an absence of lymphocytes was noted
• the thymic medulla is filled with cell debris and pyknotic nuclei





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
01/12/2022
MGI 6.17
The Jackson Laboratory