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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Hephl1cw
curly whiskers
MGI:1856476
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Hephl1cw/Hephl1cw CWD/LeJ MGI:3590075
hm2
Hephl1cw/Hephl1cw involves: CBA/Cbi MGI:3590067
ht3
Hephl1cw/Hephl1+ involves: CBA/Cbi MGI:3590068
ht4
Hephl1cw/Hephl1cw-2J (CWD/LeJ x B10.SM-H2v H2-T18b/(70NS)SnJ)F1 MGI:6315329


Genotype
MGI:3590075
hm1
Allelic
Composition
Hephl1cw/Hephl1cw
Genetic
Background
CWD/LeJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hephl1cw mutation (0 available); any Hephl1 mutation (55 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Curly whiskers in Hephl1cw/Hephl1cw mice

mortality/aging
• mean survival time is 500 days

neoplasm
• this mutation is an experimental model for B-cell lymphoma
• 85% of mice develop lymphoma
• histology indicates follicular germinal center-cell lymphoma
• immunofluoresence assays demonstrate absence of thymus cell antigens
• immunofluoresence assays reveal 100% of cells are positive for surface immuoglobulin
• a leukemic blood profile is not usually associated with this lymphoma

hematopoietic system
• less than 20% of mice develop enlarged lymphoma

immune system
• less than 20% of mice develop enlarged lymphoma

integument
• easliy observed soon after birth (J:24875)

endocrine/exocrine glands
• less than 20% of mice develop enlarged lymphoma

growth/size/body




Genotype
MGI:3590067
hm2
Allelic
Composition
Hephl1cw/Hephl1cw
Genetic
Background
involves: CBA/Cbi
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hephl1cw mutation (0 available); any Hephl1 mutation (55 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
pigmentation
• described for a CBA background

integument
• described for a CBA background
• coat hair types are not waved
• curled vibrissae are obvious soon after birth




Genotype
MGI:3590068
ht3
Allelic
Composition
Hephl1cw/Hephl1+
Genetic
Background
involves: CBA/Cbi
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hephl1cw mutation (0 available); any Hephl1 mutation (55 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
integument
• slightly curled vibrissae are not reliably observed




Genotype
MGI:6315329
ht4
Allelic
Composition
Hephl1cw/Hephl1cw-2J
Genetic
Background
(CWD/LeJ x B10.SM-H2v H2-T18b/(70NS)SnJ)F1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hephl1cw mutation (0 available); any Hephl1 mutation (55 available)
Hephl1cw-2J mutation (1 available); any Hephl1 mutation (55 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
integument
• compound heterozygotes have curly vibrissae similar to the phenotype of the individual homozygotes





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory