Phenotypes associated with this allele

• Allele Symbol: A^iapy
• Allele Name: intracisternal A particle yellow
• Allele ID: MGI:1856403
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	A^iapy/A^iapy	involves: C3H/HeJ * C57BL/6J	MGI:4835058
ot2	A^iapy/?	involves: C3H/HeJ * C57BL/6J	MGI:4835040

Genotype
MGI:4835058

hm1

• Allelic Composition: A^iapy/A^iapy
• Genetic Background: involves: C3H/HeJ * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

mortality/aging ( J:18848 )

N • homozygotes are viable unlike some other dominant agouti-yellow alleles

growth/size/body

obese ( J:18848 )

• solid yellow mice and mice extensively mottled yellow are markedly obese

pigmentation

abnormal coat/hair pigmentation ( J:18848 )

• coat color ranges from a black agouti-like to solid yellow, with some mice also mottled pseudoagouti and shades of yellow

• the coat is like that of mice that are A^vy/-

yellow coat color ( J:18848 )

• solid yellow mice are also markedly obese

• these mice show an abnormally high level of agouti mRNA compared with very low levels found in mice with pseudoagouti coloration

irregular coat pigmentation ( J:18848 )

mottled coat ( J:18848 )

• these mice show intermediate ectopic expression of agouti mRNA compared with very low levels found in mice with pseudoagouti coloration and very high levels in yellow mice

• coat color comprises varying amounts of yellow and pseudoagouti pigmentation

integument

abnormal coat/hair pigmentation ( J:18848 )

• coat color ranges from a black agouti-like to solid yellow, with some mice also mottled pseudoagouti and shades of yellow

• the coat is like that of mice that are A^vy/-

yellow coat color ( J:18848 )

• solid yellow mice are also markedly obese

• these mice show an abnormally high level of agouti mRNA compared with very low levels found in mice with pseudoagouti coloration

irregular coat pigmentation ( J:18848 )

mottled coat ( J:18848 )

• these mice show intermediate ectopic expression of agouti mRNA compared with very low levels found in mice with pseudoagouti coloration and very high levels in yellow mice

• coat color comprises varying amounts of yellow and pseudoagouti pigmentation

Genotype
MGI:4835040

ot2

• Allelic Composition: A^iapy/?
• Genetic Background: involves: C3H/HeJ * C57BL/6J

pigmentation

abnormal coat/hair pigmentation ( J:18848 )

• coat color ranges from a black agouti-like to solid yellow, with some mice also mottled psudoagouti and shades of yellow

• the coat is like that of mice that are A^vy/-

yellow coat color ( J:18848 )

• solid yellow mice are also markedly obese

• these mice show an abnormally high level of agouti mRNA compared with very low levels found in mice with pseudoagouti coloration

irregular coat pigmentation ( J:18848 )

mottled coat ( J:18848 )

• coat color comprises varying amounts of yellow and pseudoagouti pigmentation

• these mice show intermediate ectopic expression of agouti mRNA compared with very low levels found in mice with pseudoagouti coloration and very high levels in yellow mice

growth/size/body

obese ( J:18848 )

• solid yellow mice and mice extensively mottled yellow are markedly obese

integument

abnormal coat/hair pigmentation ( J:18848 )

• coat color ranges from a black agouti-like to solid yellow, with some mice also mottled psudoagouti and shades of yellow

• the coat is like that of mice that are A^vy/-

yellow coat color ( J:18848 )

• solid yellow mice are also markedly obese

• these mice show an abnormally high level of agouti mRNA compared with very low levels found in mice with pseudoagouti coloration

irregular coat pigmentation ( J:18848 )

mottled coat ( J:18848 )

• coat color comprises varying amounts of yellow and pseudoagouti pigmentation

• these mice show intermediate ectopic expression of agouti mRNA compared with very low levels found in mice with pseudoagouti coloration and very high levels in yellow mice

cellular

maternal effect ( J:18848 )

• when the mutation is inherited from the mother 97.5% of offspring are mottled; 2.5% are pseudoagouti; higher expression than when the allele is inherited from the father where only 59.4% of offspring are mottled and 40.6% resemble agouti