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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Gnrh1hpg
hypogonadal
MGI:1856393
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Gnrh1hpg/Gnrh1hpg HPG/BmJ MGI:3807534
hm2
Gnrh1hpg/Gnrh1hpg involves: 101/H * C3H/HeH MGI:2663794
cx3
Prkdcscid/Prkdcscid
Gnrh1hpg/Gnrh1hpg
STOCK Prkdcscid Gnrh1hpg/Bm MGI:3581148
cx4
Gnrh1hpg/Gnrh1hpg
Inhatm1Bay/Inhatm1Bay
involves: 129S7/SvEvBrd * C57BL/6 * HPG/Bm MGI:2662292


Genotype
MGI:3807534
hm1
Allelic
Composition
Gnrh1hpg/Gnrh1hpg
Genetic
Background
HPG/BmJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gnrh1hpg mutation (2 available); any Gnrh1 mutation (8 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Characterization of Gnrh1hpg/Gnrh1hpg mice

hematopoietic system
• Background Sensitivity: bone marrow has a modest increase in total nucleated cells, accounted for by increases in B lineage lymphocytes
• Background Sensitivity: bone marrow and spleen have significantly more B cells, both immature and mature, than normal, and increasing serum estrogen decreases the number of B cells
• Background Sensitivity: in bone marrow and spleen
• Background Sensitivity: in bone marrow and spleen
• Background Sensitivity: splenic B cell population is approximately 2 fold higher than normal although no change is found in the number of Mac1 positive splenocytes

immune system
• Background Sensitivity: bone marrow and spleen have significantly more B cells, both immature and mature, than normal, and increasing serum estrogen decreases the number of B cells
• Background Sensitivity: in bone marrow and spleen
• Background Sensitivity: in bone marrow and spleen
• Background Sensitivity: splenic B cell population is approximately 2 fold higher than normal although no change is found in the number of Mac1 positive splenocytes




Genotype
MGI:2663794
hm2
Allelic
Composition
Gnrh1hpg/Gnrh1hpg
Genetic
Background
involves: 101/H * C3H/HeH
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gnrh1hpg mutation (2 available); any Gnrh1 mutation (8 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
reproductive system
• males exhbited a reduced distance
• arrested development
• though some follicles were observed in the early stages of antrum formation, most were arrested at the pre-antral phase
• arrested development
• arrested development
• testes located in the abdomen
• arrested development
• failure of vagina to open fully
• rarely advanced beyond the diplotene stage
• underdeveloped scrotum

endocrine/exocrine glands
• arrested development
• though some follicles were observed in the early stages of antrum formation, most were arrested at the pre-antral phase
• arrested development
• arrested development
• testes located in the abdomen

growth/size/body
• male specific decrease in body weight evident at 6 weeks of age, putatively due to testosterone deficiency

nervous system
N
• no abnormalities found

skeleton
N
• no craniofacial abnormalities

homeostasis/metabolism
• reduced levels in the pituitary in both males and females
• reduced levels in the pituitary in both males and females
• reduced levels in both males and females
• reduced levels in the pituitary in both males and females
• reduced levels in the pituitary in both males and females

renal/urinary system

digestive/alimentary system
• males exhbited a reduced distance

integument

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
hypogonadotropic hypogonadism 12 with or without anosmia DOID:0090072 OMIM:614841
J:5877




Genotype
MGI:3581148
cx3
Allelic
Composition
Prkdcscid/Prkdcscid
Gnrh1hpg/Gnrh1hpg
Genetic
Background
STOCK Prkdcscid Gnrh1hpg/Bm
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gnrh1hpg mutation (2 available); any Gnrh1 mutation (8 available)
Prkdcscid mutation (114 available); any Prkdc mutation (284 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
• ovaries grafted from (SWR x SWXJ-9)F1, which are prone to granulosa cell tumor generation, do not form granulosa cell tumors in these hypogonadal immunodeficient hosts (J:14443)
• implanted human prostate adenocarcinoma tissue assessed 3 weeks after transplantation shows two histologic patterns, undifferentiated tumors and tumors that are more differentiated but have few glandular structures, and are smaller and histologically different from the tumors from the same donor transplanted into androgen repleted immunodeficiant hosts (J:138840)

homeostasis/metabolism
• no detectable serum testosterone
• serum lacks detectable prostate-specific antigen

digestive/alimentary system

endocrine/exocrine glands

liver/biliary system

renal/urinary system

reproductive system




Genotype
MGI:2662292
cx4
Allelic
Composition
Gnrh1hpg/Gnrh1hpg
Inhatm1Bay/Inhatm1Bay
Genetic
Background
involves: 129S7/SvEvBrd * C57BL/6 * HPG/Bm
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gnrh1hpg mutation (2 available); any Gnrh1 mutation (8 available)
Inhatm1Bay mutation (0 available); any Inha mutation (8 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
normal phenotype
• mice survive past 1 year of age, do not exhibit cachexia, and do not develop either gonadal or adrenal tumors





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last database update
10/19/2021
MGI 6.17
The Jackson Laboratory