Phenotypes associated with this allele

• Allele Symbol: Tgfa^wa1
• Allele Name: waved 1
• Allele ID: MGI:1856388
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tgfa^wa1/Tgfa^wa1	Not Specified	MGI:2174771

Genotype
MGI:2174771

hm1

• Allelic Composition: Tgfa^wa1/Tgfa^wa1
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

vision/eye

conjunctivitis ( J:13115 )

• one day after birth an inflammatory exudate covers the eye opening and falls away by post partum day 4

• the exudate is replaced by white excrescence which usually disappears by post partum day 18

keratoconjunctivitis ( J:13115 )

• infiltrate of polymorphonuclear leucocytes are seen

abnormal corneal stroma development ( J:13115 )

• histological preparations of 4 day old mice show enlarged nuclei in this area and there is an infiltration of polymorphonuclear leucocytes

increased corneal stroma thickness ( J:13115 )

• seen in histological examination of E17 and E18 mice

corneal opacity ( J:13115 )

• incipient opacity diminishes with age

corneal scarring ( J:13115 )

• due to environmental injury caused by eyes being open at birth

failure of eyelid fusion ( J:13115 )

• confirmed by examination of coronal sections of E17 and E18 embryos

microphthalmia ( J:13115 )

eyelids open at birth ( J:13115 )

• one or both eyelids may be open although some mice have normal eyes

immune system

conjunctivitis ( J:13115 )

• one day after birth an inflammatory exudate covers the eye opening and falls away by post partum day 4

• the exudate is replaced by white excrescence which usually disappears by post partum day 18

keratoconjunctivitis ( J:13115 )

• infiltrate of polymorphonuclear leucocytes are seen

integument

abnormal coat/ hair morphology ( J:15247 )

• all hair types form loose C-and S-shaped curves, commonly with curved tips

abnormal coat appearance ( J:15247 )

• affected mice appear abnormal at 7 or 8 days of age

• newly erupted hair tips on the dorsum incline towards the mid-line rather than straight backwards

abnormal hair texture ( J:13034 )

waved hair ( J:15247 )

• obvious at 10 days of age

• extreme waviness of the first coat is lost in later hair generations but the coat never looks normal

decreased guard hair length ( J:15247 )

abnormal hair shaft morphology ( J:15247 )

• there is local rippling most common basally with or without curvature

increased curvature of hairs ( J:15247 )

• the result of growth from curved follicles

abnormal zigzag hair morphology ( J:15247 )

• basal part of these hairs are often thick and the club itself short and squat

• local septulate areas occur in all three segments

• in most affected hairs the second and third segments are very short,broad and curved

abnormal hair follicle development ( J:15247 )

• follicles grow curved resulting in curvature to the hair

• curvature in guard hair follicles is extreme at 3 to 4 days of age compared with normal and they grow backwards into the adipose layer

• follicle arrangement in 5 day old mice is disorganized

abnormal vibrissa morphology ( J:13034 )

wavy vibrissae ( J:15247 )

• recognized between birth and 3 days as shorter and irregularly curved compared with normal

• most of vibrissae become straighter in older mice