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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Dmdmdx-3Cv
X linked muscular dystrophy 3, Verne Chapman
MGI:1856330
Summary 7 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Dmdmdx-3Cv/Dmdmdx-3Cv B6.Cg-Dmdmdx-3Cv/J MGI:3798631
hm2
Dmdmdx-3Cv/Dmdmdx-3Cv B6Ros.Cg-Dmdmdx-3Cv MGI:3798616
cx3
Dmdmdx-3Cv/Dmdmdx-3Cv
Utrntm1Ked/Utrntm1Ked
involves: 129 * C3H/HeHa * C57BL * M. m. castaneus * M. m musculus MGI:3798662
cx4
Dmdmdx-3Cv/Y
Utrntm1Ked/Utrntm1Ked
involves: 129 * C3H/HeHa * C57BL * M. m. castaneus * M. m musculus MGI:3798665
ot5
Dmdmdx-3Cv/Y B6.Cg-Dmdmdx-3Cv/J MGI:3798632
ot6
Dmdmdx-3Cv/Y B6Ros.Cg-Dmdmdx-3Cv MGI:3798617
ot7
Dmdmdx-3Cv/Y involves: C3H/HeHa * C57BL/6Ros * C57BL/10Sn * M. m. castaneus * M. m musculus MGI:3798606


Genotype
MGI:3798631
hm1
Allelic
Composition
Dmdmdx-3Cv/Dmdmdx-3Cv
Genetic
Background
B6.Cg-Dmdmdx-3Cv/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dmdmdx-3Cv mutation (1 available); any Dmd mutation (153 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• mice exhibit an alteration in Muller cell current profile such that the current is weakest in the end feet with a gradual increase moving up the proximal process unlike in wild-type cells

vision/eye
• mice exhibit an alteration in Muller cell current profile such that the current is weakest in the end feet with a gradual increase moving up the proximal process unlike in wild-type cells




Genotype
MGI:3798616
hm2
Allelic
Composition
Dmdmdx-3Cv/Dmdmdx-3Cv
Genetic
Background
B6Ros.Cg-Dmdmdx-3Cv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dmdmdx-3Cv mutation (1 available); any Dmd mutation (153 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• fewer than expected mice survive until weaning compared to Dmdmdx mice

reproductive system
• fewer than exected mice are produced compared to Dmdmdx mice

muscle
• in mutant mice, myofibers contain fibers of different diameters with centrally located nuclei
• 70% of myofibers contain central nuclei unlike in wild-type mice
• mutant mice exhibit fibrosis, fatty infiltration and necrosis in the diaphragm with increased severity upon aging
• mice exhibit fibrosis, fatty infiltration and necrosis in the diaphragm unlike in wild-type mice that increases with age




Genotype
MGI:3798662
cx3
Allelic
Composition
Dmdmdx-3Cv/Dmdmdx-3Cv
Utrntm1Ked/Utrntm1Ked
Genetic
Background
involves: 129 * C3H/HeHa * C57BL * M. m. castaneus * M. m musculus
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dmdmdx-3Cv mutation (1 available); any Dmd mutation (153 available)
Utrntm1Ked mutation (9 available); any Utrn mutation (253 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
muscle
• authors state that mice develop the same skeletal muscle abnormalities as observed in Dmdmdx Utrntm1Ked mice

nervous system
N
• unlike in Dmdmdx Utrntm1Ked mice, brain morphology is normal

respiratory system
N
• unlike in Dmdmdx Utrntm1Ked mice, lung morphology is normal

liver/biliary system
N
• liver morphology is normal

renal/urinary system
N
• kidney morphology is normal

reproductive system
N
• ovary morphology is normal




Genotype
MGI:3798665
cx4
Allelic
Composition
Dmdmdx-3Cv/Y
Utrntm1Ked/Utrntm1Ked
Genetic
Background
involves: 129 * C3H/HeHa * C57BL * M. m. castaneus * M. m musculus
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dmdmdx-3Cv mutation (1 available); any Dmd mutation (153 available)
Utrntm1Ked mutation (9 available); any Utrn mutation (253 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
muscle
• authors state that mice develop the same skeletal muscle abnormalities as observed in Dmdmdx Utrntm1Ked mice

nervous system
N
• unlike in Dmdmdx Utrntm1Ked mice, brain morphology is normal

respiratory system
N
• unlike in Dmdmdx Utrntm1Ked mice, lung morphology is normal

liver/biliary system
N
• liver morphology is normal

renal/urinary system
N
• kidney morphology is normal

reproductive system
N
• testis morphology is normal




Genotype
MGI:3798632
ot5
Allelic
Composition
Dmdmdx-3Cv/Y
Genetic
Background
B6.Cg-Dmdmdx-3Cv/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dmdmdx-3Cv mutation (1 available); any Dmd mutation (153 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
muscle
• skeletal muscles exhibit variation in fiber size and centrally located nuclei unlike in wild-type mice
• mice exhibit macrophage invasion into muscles unlike in wild-type mice
• highest specific tetanic force is lower than in wild-type mice
• at high frequencies mice titanic force is greater than in Dmdmdx-4Cv mice
• following eccentric contraction damage, force is reduced to unlike in wild-type mice that experience only a moderate drop in force but not as severely as in Dmdmdx-4Cv mice
• age exacerbates force losses

vision/eye
N
• retina morphology is normal
• mice exhibit an alteration in Muller cell current profile such that the current is weakest in the end feet with a gradual increase moving up the proximal process unlike in wild-type cells
• mice exhibit a severely attenuated b-wave amplitude compared to wild-type mice
• b-wave and OP3 wave implicit times are delayed compared to in wild-type mice
• derived positive (P2) responses are delayed compared to in wild-type mice

behavior/neurological
• mice exhibit stronger grip strength than Dmdmdx-4Cv mice

nervous system
• mice exhibit an alteration in Muller cell current profile such that the current is weakest in the end feet with a gradual increase moving up the proximal process unlike in wild-type cells




Genotype
MGI:3798617
ot6
Allelic
Composition
Dmdmdx-3Cv/Y
Genetic
Background
B6Ros.Cg-Dmdmdx-3Cv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dmdmdx-3Cv mutation (1 available); any Dmd mutation (153 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• fewer than expected mice survive until weaning compared to Dmdmdx mice

reproductive system
• fewer than exected mice are produced compared to Dmdmdx mice

muscle
• in mutant mice, myofibers contain fibers of different diameters with centrally located nuclei
• 70% of myofibers contain central nuclei unlike in wild-type mice
• mutant mice exhibit fibrosis, fatty infiltration and necrosis in the diaphragm with increased severity upon aging
• mice exhibit fibrosis, fatty infiltration and necrosis in the diaphragm unlike in wild-type mice that increases with age




Genotype
MGI:3798606
ot7
Allelic
Composition
Dmdmdx-3Cv/Y
Genetic
Background
involves: C3H/HeHa * C57BL/6Ros * C57BL/10Sn * M. m. castaneus * M. m musculus
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dmdmdx-3Cv mutation (1 available); any Dmd mutation (153 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
muscle
• mice exhibit skeletal muscle fiber degeneration
• electromyograms reveal peudomyotonia unlike in wild-type mice

cardiovascular system
• unlike wild-type, some cardiac fibrosis is observed

vision/eye
• although the a-wave amplitude is normal, the b-wave is attenuated by more than 50%





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last database update
01/18/2022
MGI 6.17
The Jackson Laboratory