Phenotypes associated with this allele

• Allele Symbol: Del(7)Tyr^c-3H
• Allele Name: deletion, Chr 7, albino 3 Harwell
• Allele ID: MGI:1856304
• Summary: 4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Del(7)Tyr^c-3H/Del(7)Tyr^c-3H	involves: 101/H * C3H/HeH	MGI:4431248
cx2	Tyr^c/Del(7)Tyr^c-3H	involves: 101/H * C3H/HeH	MGI:4431254
cx3	Tyr^c-ch/Del(7)Tyr^c-3H	involves: 101/H * C3H/HeH	MGI:4431256
cx4	Del(7)Tyr^c-3H/Del(7)Tyr^c-6H	involves: 101/H * C3H/HeH	MGI:5638543

Genotype
MGI:4431248

hm1

• Allelic Composition: Del(7)Tyr^c-3H/Del(7)Tyr^c-3H
• Genetic Background: involves: 101/H * C3H/HeH

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:5063 )

• mice die within several hours after birth

• subcutaneous injection of 10 mg glucose every 6 hours prolonged life for up to 30 hours

hematopoietic system

abnormal thymus morphology ( J:5063 )

• an occasional mouse had an abnormal thymus

homeostasis/metabolism

decreased circulating glucose level ( J:5063 )

hypoglycemia ( J:5063 )

• measureable at birth

• blood sugar values average 17 mg percent for mutant mice, 64 mg percent for control mice

• there is a deficiency of glucose-6-phosphate in both the liver and kidney

immune system

abnormal thymus morphology ( J:5063 )

• an occasional mouse had an abnormal thymus

pigmentation

abnormal skin pigmentation ( J:5063 )

absent skin pigmentation ( J:5063 )

• characteristic of albinism

renal/urinary system

abnormal kidney morphology ( J:5063 )

small kidney ( J:5063 )

• 86 percent of kidneys are severely reduced in size

integument

abnormal skin pigmentation ( J:5063 )

absent skin pigmentation ( J:5063 )

• characteristic of albinism

endocrine/exocrine glands

abnormal thymus morphology ( J:5063 )

• an occasional mouse had an abnormal thymus

Genotype
MGI:4431254

cx2

• Allelic Composition: Tyr^c/Del(7)Tyr^c-3H
• Genetic Background: involves: 101/H * C3H/HeH

pigmentation

absent coat pigmentation ( J:5063 )

• this mouse is albino

integument

absent coat pigmentation ( J:5063 )

• this mouse is albino

Genotype
MGI:4431256

cx3

• Allelic Composition: Tyr^c-ch/Del(7)Tyr^c-3H
• Genetic Background: involves: 101/H * C3H/HeH

pigmentation

abnormal coat/hair pigmentation ( J:5063 )

diluted coat color ( J:5063 )

• the coat color is intermediate between that expected for an albino mouse and a mouse homozygous for chinchilla

integument

abnormal coat/hair pigmentation ( J:5063 )

diluted coat color ( J:5063 )

• the coat color is intermediate between that expected for an albino mouse and a mouse homozygous for chinchilla

Genotype
MGI:5638543

cx4

• Allelic Composition: Del(7)Tyr^c-3H/Del(7)Tyr^c-6H
• Genetic Background: involves: 101/H * C3H/HeH

cellular

abnormal male germ cell morphology ( J:6034 )

♂

abnormal sperm nucleus morphology ( J:6034 )

♂ • at stage 13 abnormalities of sperm head condensation are seen

maternal effect ( J:6034 )

♀ • females with this genotype are unable to produce live offspring

growth/size/body

decreased body size ( J:6034 )

• mice of this genotype are runted

reproductive system

abnormal gametogenesis ( J:6034 )

♂

abnormal male germ cell morphology ( J:6034 )

♂

abnormal sperm nucleus morphology ( J:6034 )

♂ • at stage 13 abnormalities of sperm head condensation are seen

abnormal spermiogenesis ( J:6034 )

♂ • abnormal head condensation at stage 13

female infertility ( J:6034 )

♀ • complete gestational failure due to mother's genotype

male infertility ( J:6034 )

♂ • due to abnormal spermiogenesis

mortality/aging

prenatal lethality, complete penetrance ( J:6034 )

• the majority of embryos are resorbed between E10-E14 and show no gross abnormalities

• complete gestational failure due to mother's genotype