growth/size/body
|
• at 5 months of age, weight is about 80% of wild-type in the absence of doxicycline
|
endocrine/exocrine glands
|
• in the presence of doxicycline throughout embryonic development to suppress Eda-A1 transgene expression, males are identical to EdaTa-6J males, showing lack of sweat glands; mice continue to show this phenotype even after withdrawal of doxicycline from the food at 6 months of age
|
|
• preputial gland is not restored by transgene expression
|
|
• in the absence of doxicycline, sebaceous glands are enlarged relative to wild-type or EdaTa-6J males; size of individual sebocytes is the same but the numbers are increased, with excessive production of sebum
|
|
• meibomian glands are not restored by transgene expression
(J:86628)
• however, Eda transgene expression does restore the sweat glands that are absent in EdaTa-6J males
(J:86628)
(J:99510)
|
|
• in the absence of doxicycline, sebaceous glands are 200-300% larger than in wild-type or EdaTa-6J males; size of individual sebocytes is the same but the numbers are increased
• hyperplasia is seen in both glands associated with each de novo guard follicle and also in the single sebaceous gland associated with each medium follicle
• addition of doxicycline at 3 months of age reverses the hyperplasia of sebaceous glands within 3 months
|
|
• transgene expression results in hypertrophy of sebaceous glands associated with hair follicles of the eyelids
|
|
• in the absence of doxicycline
|
vision/eye
|
• meibomian glands are not restored by transgene expression
(J:86628)
• however, Eda transgene expression does restore the sweat glands that are absent in EdaTa-6J males
(J:86628)
(J:99510)
|
immune system
N |
• transgene expression rescues the susceptibility to corneal inflammation seen in EdaTa-6J males
|
reproductive system
|
• preputial gland is not restored by transgene expression
|
renal/urinary system
|
• preputial gland is not restored by transgene expression
|
integument
|
• preputial gland is not restored by transgene expression
|
|
• in the absence of doxicycline, sebaceous glands are enlarged relative to wild-type or EdaTa-6J males; size of individual sebocytes is the same but the numbers are increased, with excessive production of sebum
|
|
• in the absence of doxicycline, sebaceous glands are 200-300% larger than in wild-type or EdaTa-6J males; size of individual sebocytes is the same but the numbers are increased
• hyperplasia is seen in both glands associated with each de novo guard follicle and also in the single sebaceous gland associated with each medium follicle
• addition of doxicycline at 3 months of age reverses the hyperplasia of sebaceous glands within 3 months
|
|
• transgene expression results in hypertrophy of sebaceous glands associated with hair follicles of the eyelids
|
|
• in the absence of doxicycline
|
|
• in the absence of doxicycline, the number of medium hairs is increased to a similar extent as in EdaTa-6J males
• however, total hair numbers are unchanged
• in the presence of doxicycline throughout embryonic development to suppress Eda-A1 transgene expression, males are identical to EdaTa-6J males, showing lack of tail hair, guard hair and zigzag hair; mice continue to show this phenotype even after withdrawal of doxicycline from the food at 6 months of age
|
|
• in the absence of doxicycline, tail hairs are reduced in number
• however, the hair behind the ears that is missing in EdaTa-6J males is fully restored when the transgene is expressed (absence of doxicycline)
|
|
• in the absence of doxicycline, tail hairs are reduced in length
|
|
• in the absence of doxicycline, mutants have somewhat scruffy disordered coat hair compared to wild-type and EdaTa-6J males
|
|
• zigzag hairs are not restored by transgene expression (absence of doxicycline)
• however, the number of guard hairs is restored to wild-type levels
|
|
• tail ridges on skin surfaces are absent in the absence of doxicycline
|
|
• meibomian glands are not restored by transgene expression
(J:86628)
• however, Eda transgene expression does restore the sweat glands that are absent in EdaTa-6J males
(J:86628)
(J:99510)
|