All Phenotypes Pax6<Sey> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Pax6^Sey
small eye
MGI:1856155

Summary

19 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Pax6^Sey/Pax6^Sey	B10.Cg-Pax6^Sey	MGI:3588959
hm2	Pax6^Sey/Pax6^Sey	CBACa.Cg-Pax6^Sey	MGI:3771028
hm3	Pax6^Sey/Pax6^Sey	C.Cg-Pax6^Sey	MGI:3709573
hm4	Pax6^Sey/Pax6^Sey	involves: C57BL/6	MGI:3771035
hm5	Pax6^Sey/Pax6^Sey	involves: C57BL/6J * DBA/2J	MGI:2179952
hm6	Pax6^Sey/Pax6^Sey	involves: ICR	MGI:3771067
hm7	Pax6^Sey/Pax6^Sey	involves: Swiss	MGI:2385726
hm8	Pax6^Sey/Pax6^Sey	Not Specified	MGI:2166662
ht9	Pax6^Sey/Pax6⁺	B10.Cg-Pax6^Sey	MGI:3588960
ht10	Pax6^Sey/Pax6⁺	C.Cg-Pax6^Sey	MGI:3709574
ht11	Pax6^Sey/Pax6⁺	involves: C57BL/6	MGI:3771036
ht12	Pax6^Sey/Pax6⁺	Not Specified	MGI:2170872
ht13	Pax6^Sey/Pax6^Sey-H	involves: 101/H * C3H/HeH * C57BL/10	MGI:3767472
ht14	Pax6^Sey-Dey/Pax6^Sey	involves: C3H/HeJ	MGI:4358875
cx15	Pax6^Sey/Pax6^Sey-Neu Tg(Hbb-b1)83Clo/0	involves: 102 * C3H * C57BL * CBA/Ca * CD-1 * SJL	MGI:3771027
cx16	Gli2^tm1Alj/Gli2^tm1Alj Pax6^Sey/Pax6^Sey	involves: 129S1/Sv * 129X1/SvJ	MGI:3664781
cx17	Emx2^tm1Sia/Emx2^tm1Sia Pax6^Sey/Pax6^Sey	involves: C57BL/6 * CBA	MGI:3580109
cx18	Pax6^Sey/Pax6^Sey Tg(PAX6)77Ndha/?	involves: C57BL/6 * CBA	MGI:5316843
cx19	Pax6^Sey/Pax6^Sey Tg(Hbb-b1)83Clo/0	involves: C57BL * CBA/Ca * CD-1 * SJL	MGI:3771026

Allelic Composition	Pax6^Sey/Pax6^Sey
Genetic Background	B10.Cg-Pax6^Sey

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pax6^Sey mutation (9 available); any Pax6 mutation (90 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

perinatal lethality, incomplete penetrance ( J:8534 )

• mice are still viable at E11.5 but are seldom born

vision/eye

decreased eye pigmentation ( J:8534 )

• fail to develop eye pigment by E11.5 in mice that lack the lens

aphakia ( J:8534 )

• at E10.5, mice lack lenses

• however, optic vessicles are normal in size

nervous system

absent olfactory bulb ( J:8534 )

• at birth

respiratory system

abnormal nasal bone morphology ( J:8534 )

• only small frontonasal protuberances formed by E11.5 which later fuse with maxillary processes

absent nasal pit ( J:8534 )

• at E10.5, mice lack the nasal pit

craniofacial

abnormal nasal bone morphology ( J:8534 )

• only small frontonasal protuberances formed by E11.5 which later fuse with maxillary processes

absent nasal pit ( J:8534 )

• at E10.5, mice lack the nasal pit

pigmentation

decreased eye pigmentation ( J:8534 )

• fail to develop eye pigment by E11.5 in mice that lack the lens

skeleton

abnormal nasal bone morphology ( J:8534 )

• only small frontonasal protuberances formed by E11.5 which later fuse with maxillary processes

growth/size/body

abnormal nasal bone morphology ( J:8534 )

• only small frontonasal protuberances formed by E11.5 which later fuse with maxillary processes

Allelic Composition	Pax6^Sey/Pax6^Sey
Genetic Background	CBACa.Cg-Pax6^Sey

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pax6^Sey mutation (9 available); any Pax6 mutation (90 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

craniofacial

craniofacial phenotype ( J:43913 )

N	• mice do not possess supernumerary incisors

abnormal craniofacial bone morphology ( J:43913 )

• all mice exhibit a median cartilaginous rod unlike wild-type mice

abnormal nasal capsule morphology ( J:43913 )

• 33% of mice posses unilateral or bilateral ectopic cartilaginous spurs derived from the antero-lateral aspect of the nasal capsule

• unlike in wild-type mice the nasal capsule surrounds the entire are of the developing incisor teeth

respiratory system

abnormal nasal capsule morphology ( J:43913 )

• 33% of mice posses unilateral or bilateral ectopic cartilaginous spurs derived from the antero-lateral aspect of the nasal capsule

• unlike in wild-type mice the nasal capsule surrounds the entire are of the developing incisor teeth

skeleton

abnormal craniofacial bone morphology ( J:43913 )

• all mice exhibit a median cartilaginous rod unlike wild-type mice

abnormal nasal capsule morphology ( J:43913 )

• 33% of mice posses unilateral or bilateral ectopic cartilaginous spurs derived from the antero-lateral aspect of the nasal capsule

• unlike in wild-type mice the nasal capsule surrounds the entire are of the developing incisor teeth

growth/size/body

abnormal nasal capsule morphology ( J:43913 )

• 33% of mice posses unilateral or bilateral ectopic cartilaginous spurs derived from the antero-lateral aspect of the nasal capsule

• unlike in wild-type mice the nasal capsule surrounds the entire are of the developing incisor teeth

Allelic Composition	Pax6^Sey/Pax6^Sey
Genetic Background	C.Cg-Pax6^Sey

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pax6^Sey mutation (9 available); any Pax6 mutation (90 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

abnormal iridocorneal angle ( J:119940 )

abnormal cornea morphology ( J:119940 )

• animals show corneal edema with deranged collagen bundles

corneal vascularization ( J:119940 )

anterior iris synechia ( J:119940 )

abnormal corneal endothelium morphology ( J:119940 )

• corneal epithelium has a bubbly appearance like Foxe3^tm1Pca /+ or Foxe3^dyl /+ mice

cardiovascular system

corneal vascularization ( J:119940 )

Allelic Composition	Pax6^Sey/Pax6^Sey
Genetic Background	involves: C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pax6^Sey mutation (9 available); any Pax6 mutation (90 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:2301 )

• mice die soon after birth because of inability to breathe during suckling

vision/eye

anophthalmia ( J:2301 )

• at E15, homozygotes have no visible eyes

craniofacial

abnormal nasal cavity morphology ( J:2301 )

short snout ( J:2301 )

• defects in nasal cavity development results in shortened, imperforate snout

respiratory system

abnormal nasal cavity morphology ( J:2301 )

growth/size/body

abnormal nasal cavity morphology ( J:2301 )

short snout ( J:2301 )

• defects in nasal cavity development results in shortened, imperforate snout

Allelic Composition	Pax6^Sey/Pax6^Sey
Genetic Background	involves: C57BL/6J * DBA/2J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pax6^Sey mutation (9 available); any Pax6 mutation (90 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal neuron differentiation ( J:94457 )

• decrease in the number of neurons generated in the cerebral cortex

• 2.4 fold increase in subventricular zone precursors but not in ventricular zone precursors of the cortex

abnormal brain development ( J:126065 )

• at E14, proliferation of marginal zone neural progenitors of the cerebral cortex is increased three time compared to in wild-type mice

abnormal forebrain development ( J:94457 )

• altered dorso-ventral patterning of the forebrain

abnormal telencephalon development ( J:94457 )

• altered dorso-ventral telencephalic boundary

thin cortical plate ( J:94457 )

• decreased thickness of the cortical plate

abnormal embryonic/fetal subventricular zone morphology ( J:94457 )

• 2.4 fold increase in subventricular zone precursors but not in ventricular zone precursors of the cortex

cellular

abnormal neuron differentiation ( J:94457 )

• decrease in the number of neurons generated in the cerebral cortex

• 2.4 fold increase in subventricular zone precursors but not in ventricular zone precursors of the cortex

Allelic Composition	Pax6^Sey/Pax6^Sey
Genetic Background	involves: ICR

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pax6^Sey mutation (9 available); any Pax6 mutation (90 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal cerebellum morphology ( J:103551 )

• at E18.5, mice display a teardrop shaped cerebellum due to thinning of the cerebellar vermis and thickening of the lateral hemisphere in addition to alterations in the medial to lateral profile of areas from sagittal sections

abnormal cerebellum external granule cell layer morphology ( J:103551 )

• the external granule cell layer area is increased compared to wild-type

ectopic Purkinje cell ( J:103551 )

• Purkinje cells are located abnormally deep compared to in wild-type mice

• ectopic Purkinje cells are located in the distinct clusters in the vermis and hemisphere and in the inferior colliculus

• 25% of Purkinje cells are located deep to the developing Purkinje cell plate compared to only 3% in wild-type mice

abnormal cerebellar granule cell morphology ( J:103551 )

• in culture, granule cells exhibit increased numbers of cellular aggregates due to increased proliferation

abnormal cerebellum vermis morphology ( J:103551 )

• the vermis is thinned

Allelic Composition	Pax6^Sey/Pax6^Sey
Genetic Background	involves: Swiss

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pax6^Sey mutation (9 available); any Pax6 mutation (90 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

abnormal lens vesicle development ( J:25250 )

• absence of lens placode and lens pit

absent lens vesicle ( J:25250 )

abnormal optic vesicle formation ( J:25250 )

• broader rather than proximally constricted at E9.5

• optic stalk retains a lumen through E15.5

• contact of optic vesicle with surface ectoderm at E9.5 but progressively lost as mesenchymal cells intervene

nervous system

abnormal cerebral cortex morphology ( J:119877 )

• while apoptosis and proliferation rates are unchanged, a greater number of cells exit the cell cycle and differentiate than in wild-type mice

thin cerebral cortex ( J:119877 )

• at E12.5, 114+/-7.1 um compared to 135+/+6.2 um for wild-type cortex

respiratory system

abnormal respiratory system development ( J:25250 )

• lateral nasal processes absent at E10.5

absent nasal placodes ( J:25250 )

• nasal placodes not detectable at E9.5

taste/olfaction

absent nasal placodes ( J:25250 )

• nasal placodes not detectable at E9.5

craniofacial

absent nasal placodes ( J:25250 )

• nasal placodes not detectable at E9.5

Allelic Composition	Pax6^Sey/Pax6^Sey
Genetic Background	Not Specified

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pax6^Sey mutation (9 available); any Pax6 mutation (90 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

perinatal lethality, complete penetrance ( J:22316 )

• develop to term but die of breathing problems associated with the lack of a nose

vision/eye

anophthalmia ( J:22316 )

nervous system

abnormal neuron differentiation ( J:112802 )

• at E10.5 Nkx2.2+ V3 progenitors show dorsal expansion in the thoracic and cervical regions of the spinal cord

abnormal pretectal region morphology ( J:98539 )

• anterior pretectum is reduced but present and the posterior pretectum scarcely exists at E12.5

abnormal diencephalon morphology ( J:98539 )

• diencephalic structures were poor but present

small thalamus ( J:98539 )

• prethalamus and thalamus were reduced at E12.5

abnormal ventral interneuron 1 morphology ( J:87771 )

• E17.5 mutants show a greater than 90% reduction in the number of calbindin-positive cells close to the white matter in the spinal cord, indicating that Renshaw cells fail to develop

abnormal synaptic transmission ( J:87771 )

• no synaptic potentials are evoked by ventral root stimulation, indicating that Renshaw cell inputs to motor neurons are absent

respiratory system

abnormal nose morphology ( J:22316 )

• lack nose

respiratory failure ( J:22316 )

• due to lack of nose

• cause of perinatal death

craniofacial

abnormal nose morphology ( J:22316 )

• lack nose

cellular

abnormal neuron differentiation ( J:112802 )

• at E10.5 Nkx2.2+ V3 progenitors show dorsal expansion in the thoracic and cervical regions of the spinal cord

growth/size/body

abnormal nose morphology ( J:22316 )

• lack nose

Allelic Composition	Pax6^Sey/Pax6⁺
Genetic Background	B10.Cg-Pax6^Sey

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pax6^Sey mutation (9 available); any Pax6 mutation (90 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

small lens ( J:8534 )

• with many vacuolated cells

• sometimes incompletely separated from overlying ectoderm

retina fold ( J:8534 )

• folding of the retinal epithelium around the anterior of the lens

Allelic Composition	Pax6^Sey/Pax6⁺
Genetic Background	C.Cg-Pax6^Sey

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pax6^Sey mutation (9 available); any Pax6 mutation (90 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

abnormal lens vesicle development ( J:119940 )

• at E11.5, lens pit or vesicle is smaller than in wild-type

• reduction in lens vesicle tissue volume is similar to that observed in Foxe3^dyl homozygotes, while in Foxe3-heterozygotes volume reduction is intermediate between homozygotes and wild-type

Allelic Composition	Pax6^Sey/Pax6⁺
Genetic Background	involves: C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pax6^Sey mutation (9 available); any Pax6 mutation (90 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

abnormal optic cup morphology ( J:2301 )

• at E15, fissure of optic cup is often delayed in closing

• at E15, there is folding at the margin of the optic cup resulting in a keyhole-shaped opening

microphthalmia ( J:2301 )

• at E15 heterozygotes have smaller eyes than wild-type

Allelic Composition	Pax6^Sey/Pax6⁺
Genetic Background	Not Specified

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pax6^Sey mutation (9 available); any Pax6 mutation (90 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Development of the Pax6^Sey/Pax6⁺ lens

vision/eye

abnormal optic nerve morphology ( J:22316 )

• myelinated nerve counts lower than in controls

• cross sectional area in males significantly smaller than in controls

abnormal anterior eye segment morphology ( J:71087 )

• display a persistent plug of ectoderm linking the corneal and anterior lens epithelia at E16.6

• the lens-corneal bridge exhibits high levels of apoptosis but normal proliferation

abnormal corneal epithelium morphology ( J:5093 )

• hypertrophy

abnormal eye anterior chamber morphology ( J:71087 )

• reduced anterior chamber, with multiple sites of adhesion between the anterior surface of the lens and the corneal endothelium

abnormal lens morphology ( J:71087 )

• the lens shows evidence of degeneration

abnormal lens development ( J:71087 )

• the lens is developmentally delayed

abnormal lens vesicle development ( J:71087 )

• persistence of the lens vesicular cavity

abnormal lens epithelium morphology ( J:5093 )

• hypertrophy

abnormal lens fiber morphology ( J:71087 )

• extensive vacuolation of the primary lens fibers

delayed eyelid fusion ( J:71087 )

• delayed fusion of the eyelids

microphthalmia ( J:12101 , J:71087 )

• microphthalmia, but highly variable from almost unnoticeable to very small (J:12101)

• never anophthalmic (J:12101)

abnormal retina morphology ( J:5093 )

abnormal retina pigment epithelium morphology ( J:5093 )

• frequently necrotic in adults

abnormal retina photoreceptor layer morphology ( J:5093 )

• sensory cells in only 15% of eyes

growth/size/body

decreased body size ( J:12101 )

• reduced size

nervous system

abnormal optic nerve morphology ( J:22316 )

• myelinated nerve counts lower than in controls

• cross sectional area in males significantly smaller than in controls

pigmentation

abnormal retina pigment epithelium morphology ( J:5093 )

• frequently necrotic in adults

Allelic Composition	Pax6^Sey/Pax6^Sey-H
Genetic Background	involves: 101/H * C3H/HeH * C57BL/10

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pax6^Sey mutation (9 available); any Pax6 mutation (90 available)
Pax6^Sey-H mutation (2 available); any Pax6 mutation (90 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

craniofacial

abnormal maxillary shelf morphology ( J:8534 )

• at E13.5, the maxillae are not fused and there is only a small bilobed protrusion in the frontonasal position that in some mice may fuse on one side

abnormal face development ( J:8534 )

• facial development is retarded compared to wild-type and Pax6^Sey homozygotes

absent snout ( J:8534 )

vision/eye

anophthalmia ( J:8534 )

• while small bleds are present in the area occupied by the eye they contain no brain involvement

embryo

decreased embryo size ( J:8534 )

• at E13.5, mice are smaller than wild-type and Pax6^sey homozygotes

skeleton

abnormal maxillary shelf morphology ( J:8534 )

• at E13.5, the maxillae are not fused and there is only a small bilobed protrusion in the frontonasal position that in some mice may fuse on one side

digestive/alimentary system

abnormal maxillary shelf morphology ( J:8534 )

• at E13.5, the maxillae are not fused and there is only a small bilobed protrusion in the frontonasal position that in some mice may fuse on one side

growth/size/body

abnormal maxillary shelf morphology ( J:8534 )

• at E13.5, the maxillae are not fused and there is only a small bilobed protrusion in the frontonasal position that in some mice may fuse on one side

abnormal face development ( J:8534 )

• facial development is retarded compared to wild-type and Pax6^Sey homozygotes

absent snout ( J:8534 )

decreased embryo size ( J:8534 )

• at E13.5, mice are smaller than wild-type and Pax6^sey homozygotes

Allelic Composition	Pax6^Sey-Dey/Pax6^Sey
Genetic Background	involves: C3H/HeJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pax6^Sey mutation (9 available); any Pax6 mutation (90 available)
Pax6^Sey-Dey mutation (1 available); any Pax6 mutation (90 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

respiratory system

absent nasal placodes ( J:14117 )

• 23% of embryos from a heterozygous intercross show not development of nasal placodes

taste/olfaction

absent nasal placodes ( J:14117 )

• 23% of embryos from a heterozygous intercross show not development of nasal placodes

vision/eye

absent lens vesicle ( J:14117 )

• 23% of embryos from a heterozygous intercross show no development of the lens

coloboma ( J:14117 )

• approximately a third of the embryos 14.5 days or older from heterozygous intercrosses are colobomatous

craniofacial

absent nasal placodes ( J:14117 )

• 23% of embryos from a heterozygous intercross show not development of nasal placodes

Allelic Composition	Pax6^Sey/Pax6^Sey-Neu Tg(Hbb-b1)83Clo/0
Genetic Background	involves: 102 * C3H * C57BL * CBA/Ca * CD-1 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pax6^Sey mutation (9 available); any Pax6 mutation (90 available)
Pax6^Sey-Neu mutation (1 available); any Pax6 mutation (90 available)
Tg(Hbb-b1)83Clo mutation (4 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

craniofacial

abnormal craniofacial bone morphology ( J:43913 )

• all mice exhibit a median cartilaginous rod unlike wild-type mice

supernumerary incisors ( J:43913 )

• 22% of mice possess a single supernumerary upper incisor tooth

abnormal nasal capsule morphology ( J:43913 )

• 22% of mice posses unilateral or bilateral ectopic cartilaginous spurs derived from the antero-lateral aspect of the nasal capsule

respiratory system

abnormal nasal capsule morphology ( J:43913 )

• 22% of mice posses unilateral or bilateral ectopic cartilaginous spurs derived from the antero-lateral aspect of the nasal capsule

skeleton

abnormal craniofacial bone morphology ( J:43913 )

• all mice exhibit a median cartilaginous rod unlike wild-type mice

supernumerary incisors ( J:43913 )

• 22% of mice possess a single supernumerary upper incisor tooth

abnormal nasal capsule morphology ( J:43913 )

• 22% of mice posses unilateral or bilateral ectopic cartilaginous spurs derived from the antero-lateral aspect of the nasal capsule

growth/size/body

supernumerary incisors ( J:43913 )

• 22% of mice possess a single supernumerary upper incisor tooth

abnormal nasal capsule morphology ( J:43913 )

• 22% of mice posses unilateral or bilateral ectopic cartilaginous spurs derived from the antero-lateral aspect of the nasal capsule

Allelic Composition	Gli2^tm1Alj/Gli2^tm1Alj Pax6^Sey/Pax6^Sey
Genetic Background	involves: 129S1/Sv * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gli2^tm1Alj mutation (0 available); any Gli2 mutation (169 available)
Pax6^Sey mutation (9 available); any Pax6 mutation (90 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal neuron differentiation ( J:112802 )

• at E10.5 Nkx2.2+ V3 progenitors show dorsal expansion in the thoracic region similar to Pax6 single homozygotes

cellular

abnormal neuron differentiation ( J:112802 )

• at E10.5 Nkx2.2+ V3 progenitors show dorsal expansion in the thoracic region similar to Pax6 single homozygotes

Allelic Composition	Emx2^tm1Sia/Emx2^tm1Sia Pax6^Sey/Pax6^Sey
Genetic Background	involves: C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Emx2^tm1Sia mutation (1 available); any Emx2 mutation (23 available)
Pax6^Sey mutation (9 available); any Pax6 mutation (90 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal brain morphology ( J:98539 )

• an amorphous structure was present where normally the thalamus/pretectum develops at E12.5

• the supraopto-paraventricular area was lost at E12.5

absent choroid plexus ( J:98539 )

• choroid plexus was never apparent at E12.5

abnormal brain commissure morphology ( J:98539 )

• the commissural plate was caudally expanded

abnormal tectum morphology ( J:98539 )

• mirror image duplication of tectum at E18.5, however duplication of the cerebellum or tegmentum did not occur

abnormal pretectal region morphology ( J:98539 )

• both the non-commissure region and the commissure region of the pretectum were absent at E12.5

abnormal thalamus morphology ( J:98539 )

• prethalamus and thalamus were not apparent at E12.5

• zona limitans intrathalamica was never formed

absent diencephalon ( J:98539 )

• diencephalic structures were not apparent at E12.5

abnormal telencephalon morphology ( J:98539 )

• the choroidal roof at the telencephalic level did not develop

abnormal Ammon gyrus morphology ( J:98539 )

• Ammon's horn did not develop at E12.5

absent hippocampus ( J:98539 )

• prospective hippocampus was absent at E12.5

abnormal cerebral cortex morphology ( J:98539 )

• greatly reduced pallium at E18.5 that was lost in the medial portion, greatly reduced but present neopallium at E12.5 and absent cortical hem at E12.5

abnormal embryonic/fetal subventricular zone morphology ( J:98539 )

• hyperplastic ganglionic eminences

Allelic Composition	Pax6^Sey/Pax6^Sey Tg(PAX6)77Ndha/?
Genetic Background	involves: C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pax6^Sey mutation (9 available); any Pax6 mutation (90 available)
Tg(PAX6)77Ndha mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

vision/eye phenotype ( J:34194 )

N	• normal eye size

taste/olfaction

taste/olfaction phenotype ( J:34194 )

N	• nasal cavity present • normal olfactory epithelium

nervous system

nervous system phenotype ( J:34194 )

N	• olfactory bulbs normal • subventricular zone of cerebral hemispheres normal

Allelic Composition	Pax6^Sey/Pax6^Sey Tg(Hbb-b1)83Clo/0
Genetic Background	involves: C57BL * CBA/Ca * CD-1 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pax6^Sey mutation (9 available); any Pax6 mutation (90 available)
Tg(Hbb-b1)83Clo mutation (4 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

craniofacial

abnormal craniofacial bone morphology ( J:43913 )

• all mice exhibit a median cartilaginous rod unlike wild-type mice

supernumerary incisors ( J:43913 )

• 43% of mice from the agouti sub-line exhibit supernumerary upper incisor teeth and 14% of the non-agouti line possess a single supernumerary upper incisor tooth

abnormal nasal capsule morphology ( J:43913 )

• 86% mice from the agouti sub-line, but none from the non-agouti sub-line, posses unilateral or bilateral ectopic cartilaginous spurs derived from the antero-lateral aspect of the nasal capsule

respiratory system

abnormal nasal capsule morphology ( J:43913 )

• 86% mice from the agouti sub-line, but none from the non-agouti sub-line, posses unilateral or bilateral ectopic cartilaginous spurs derived from the antero-lateral aspect of the nasal capsule

skeleton

abnormal craniofacial bone morphology ( J:43913 )

• all mice exhibit a median cartilaginous rod unlike wild-type mice

supernumerary incisors ( J:43913 )

• 43% of mice from the agouti sub-line exhibit supernumerary upper incisor teeth and 14% of the non-agouti line possess a single supernumerary upper incisor tooth

abnormal nasal capsule morphology ( J:43913 )

• 86% mice from the agouti sub-line, but none from the non-agouti sub-line, posses unilateral or bilateral ectopic cartilaginous spurs derived from the antero-lateral aspect of the nasal capsule

growth/size/body

supernumerary incisors ( J:43913 )

• 43% of mice from the agouti sub-line exhibit supernumerary upper incisor teeth and 14% of the non-agouti line possess a single supernumerary upper incisor tooth

abnormal nasal capsule morphology ( J:43913 )

• 86% mice from the agouti sub-line, but none from the non-agouti sub-line, posses unilateral or bilateral ectopic cartilaginous spurs derived from the antero-lateral aspect of the nasal capsule

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