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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Foxn1nu
nude
MGI:1856108
Summary 29 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Foxn1nu/Foxn1nu B6.Cg-Foxn1nu MGI:5437217
hm2
Foxn1nu/Foxn1nu B6NTac.Cg-Foxn1nu/Tac MGI:3617401
hm3
Foxn1nu/Foxn1nu involves: BALB/c MGI:3806503
hm4
Foxn1nu/Foxn1nu involves: C57BL/10 MGI:5521334
hm5
Foxn1nu/Foxn1nu involves: C57BL/10Sn * C57BR/cd MGI:5521191
hm6
Foxn1nu/Foxn1nu involves: CBA MGI:5521577
hm7
Foxn1nu/Foxn1nu involves: CD-1 MGI:5521336
hm8
Foxn1nu/Foxn1nu involves: NIH Swiss MGI:5522729
hm9
Foxn1nu/Foxn1nu involves: NMRI MGI:2662818
hm10
Foxn1nu/Foxn1nu Not Specified MGI:2680668
hm11
Foxn1nu/Foxn1nu NU/J MGI:5521192
ht12
Foxn1nu/Foxn1+ B6N.Cg-Foxn1nu MGI:5521303
ht13
Foxn1nu/Foxn1+ C3N.Cg-Foxn1nu MGI:5521305
ht14
Foxn1nu/Foxn1+ C.Cg-Foxn1nu MGI:3848173
ht15
Foxn1nu/Foxn1+ involves: BALB/c MGI:5521193
ht16
Foxn1nu/Foxn1+ NFS.Cg-Foxn1nu MGI:5521298
cn17
Foxn1nu/Foxn1tm1.1Dmsu
Tg(CAG-cre/Esr1*)5Amc/0
involves: 129/Sv * C57BL/6 * CBA * SJL MGI:4454658
cx18
Foxn1nu/Foxn1nu
Tgfb1tm1Doe/Tgfb1tm1Doe
involves: 129S2/SvPas * BALB/c * CF-1 MGI:3622470
cx19
Foxn1nu/Foxn1nu
Ivltm1Dji/Ivltm1Dji
involves: 129S4/SvJae * BALB/c * C57BL/6 MGI:3583342
cx20
Foxn1nu/Foxn1nu
Msx2tm1Rilm/Msx2tm1Rilm
involves: 129S4/SvJae * BALB/c * CD-1 MGI:5521205
cx21
Btnl1tm1(KOMP)Mbp/Btnl1tm1(KOMP)Mbp
Foxn1nu/Foxn1nu
involves: albino stock * C57BL/6N MGI:6446219
cx22
Foxn1nu/Foxn1nu
Fv4r/Fv4r
involves: BALB/c MGI:3505597
cx23
Foxn1nu/Foxn1nu
Map3k14aly/Map3k14aly
involves: BALB/cAJcl * C57BL/6J MGI:4361561
cx24
Foxn1nu/Foxn1nu
Srcr/Srcr+
involves: BALB/c * C57BL/6 MGI:3045968
cx25
Dmdmdx/Y
Foxn1nu/Foxn1nu
involves: C57BL/10ScSn MGI:5521335
cx26
Foxn1nu/Foxn1nu
Tg(Foxn1)G2Hon/0
involves: CD-1 MGI:2174844
cx27
Foxn1nu/Foxn1nu
Gpc1tm1.1Alan/Gpc1tm1.1Alan
involves: CD-1 MGI:3798863
cx28
Foxn1nu/Foxn1nu
Tg(Foxn1)E1Hon/0
involves: CD-1 MGI:2174843
cx29
Dh/Dh+
Foxn1nu/Foxn1nu
involves: N:NIH(S) MGI:3819387


Genotype
MGI:5437217
hm1
Allelic
Composition
Foxn1nu/Foxn1nu
Genetic
Background
B6.Cg-Foxn1nu
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxn1nu mutation (43 available); any Foxn1 mutation (96 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
skeleton
• increased at 4 weeks of age but declines later
• reduced cortical bone structure
• reduced trabecular bone structure




Genotype
MGI:3617401
hm2
Allelic
Composition
Foxn1nu/Foxn1nu
Genetic
Background
B6NTac.Cg-Foxn1nu/Tac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxn1nu mutation (43 available); any Foxn1 mutation (96 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• mice showed no sign of lesion development for up to 12 to 14 weeks post-infection; after 20 weeks, all lesions remain small




Genotype
MGI:3806503
hm3
Allelic
Composition
Foxn1nu/Foxn1nu
Genetic
Background
involves: BALB/c
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxn1nu mutation (43 available); any Foxn1 mutation (96 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• only 2 mice survived for more than 10 days after infection and 90% of mice die by 14 days post infection

immune system
• mice are resistant to Pseudomonas aerugiosa exotoxin-induced liver damage and decreased circulating cytokine levels, including TNF, unlike similarly treated wild-type mice
• following exposure to Pseudomonas aerugiosa exotoxin
• following exposure to Pseudomonas aerugiosa exotoxin
• mice are resistant to Pseudomonas aerugiosa exotoxin-induced liver damage and circulating cytokine levels, including TNF, unlike similarly treated wild-type mice
• following exposure to Pseudomonas aerugiosa exotoxin
• more severe following infection with HSV-1 strain CJ394 compared to controls
• mice are resistant to Pseudomonas aerugiosa exotoxin-induced liver damage and decreased circulating cytokine levels, including TNF, unlike similarly treated wild-type mice
• following infection with HSV-1 strain CJ394 young mice (7-10 weeks of age) develop more severe ocular disease and develop severe extra ocular disease not seen in controls
• extraocular disease is more severe than in heterozygous mice
• only 2 mice survived for more than 10 days after infection and 90% of mice die by 14 days post infection

homeostasis/metabolism
• mice are resistant to Pseudomonas aerugiosa exotoxin-induced liver damage and decreased circulating cytokine levels, including TNF, unlike similarly treated wild-type mice
• following exposure to Pseudomonas aerugiosa exotoxin
• following exposure to Pseudomonas aerugiosa exotoxin
• mice are resistant to Pseudomonas aerugiosa exotoxin-induced liver damage and circulating cytokine levels, including TNF, unlike similarly treated wild-type mice
• following exposure to Pseudomonas aerugiosa exotoxin
• develop within 4-8 weeks of plasma cell transplant; ascites contains many plasma cells, some of which are multinucleated and contain high levels of IgA

integument
• nail phenotype is 100% penetrant
• broken with blunt ends

neoplasm
• plasma cells isolated from BALB/c/C57BL/6 mice generate plasmacytomas in pristane-treated BALB/c nude mice within 4-8 weeks

cellular
• plasmacytomas generated are near-tetraploid and contain the t(12;15) translocation

vision/eye
• more severe following infection with HSV-1 strain CJ394 compared to controls




Genotype
MGI:5521334
hm4
Allelic
Composition
Foxn1nu/Foxn1nu
Genetic
Background
involves: C57BL/10
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxn1nu mutation (43 available); any Foxn1 mutation (96 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
muscle
• elevation in hydroxyproline in the tibialis anterior and soleus muscles on a per muscle and wet weight basis at 3 weeks of age but not at 24 weeks of age
• in the tibialis anterior and soleus muscles at 3 weeks of age
• in the limb muscles at 3 weeks of age




Genotype
MGI:5521191
hm5
Allelic
Composition
Foxn1nu/Foxn1nu
Genetic
Background
involves: C57BL/10Sn * C57BR/cd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxn1nu mutation (43 available); any Foxn1 mutation (96 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• at E16 in the thymic rudiment TR3+ cells are absent and the number of TR4+ and TR5+ cells are reduced

hematopoietic system
• at E16 in the thymic rudiment TR3+ cells are absent and the number of TR4+ and TR5+ cells are reduced

endocrine/exocrine glands
• at E16 in the thymic rudiment TR3+ cells are absent and the number of TR4+ and TR5+ cells are reduced




Genotype
MGI:5521577
hm6
Allelic
Composition
Foxn1nu/Foxn1nu
Genetic
Background
involves: CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxn1nu mutation (43 available); any Foxn1 mutation (96 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• decrease in the number of agranulocytes (lymphocytes plus monocytes) in the peripheral blood in older mice
• very few theta isoantigen expressing cells are detected in the lymph nodes
• no difference is detected in the number of theta antigen expressing cells in the brain
• injection of phytohaemagglutinin does not result in an increase in popliteal or inguinal node weight
• fewer plaque forming cells per spleen and when normalized to the number of nucleated spleen cells following immunization with sheep red blood cells
• very few theta isoantigen expressing cells are detected in the lymph nodes
• fewer plaque forming cells per spleen and when normalized to the number of nucleated spleen cells following immunization with sheep red blood cells

hematopoietic system
• decrease in the number of agranulocytes (lymphocytes plus monocytes) in the peripheral blood in older mice
• very few theta isoantigen expressing cells are detected in the lymph nodes
• no difference is detected in the number of theta antigen expressing cells in the brain
• injection of phytohaemagglutinin does not result in an increase in popliteal or inguinal node weight
• fewer plaque forming cells per spleen and when normalized to the number of nucleated spleen cells following immunization with sheep red blood cells




Genotype
MGI:5521336
hm7
Allelic
Composition
Foxn1nu/Foxn1nu
Genetic
Background
involves: CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxn1nu mutation (43 available); any Foxn1 mutation (96 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands
N
• impact of immobilization stress on luteinizing hormone level is reduced compared to heterozygous controls

homeostasis/metabolism
• impact of immobilization stress on luteinizing hormone level is reduced compared to heterozygous controls

immune system

hematopoietic system




Genotype
MGI:5522729
hm8
Allelic
Composition
Foxn1nu/Foxn1nu
Genetic
Background
involves: NIH Swiss
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxn1nu mutation (43 available); any Foxn1 mutation (96 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• when maintained under SPF conditions, mortality from 6 weeks to 12 months of age is similar to controls
• after 12 months, of age the mortality rate per month is about twice that of heterozygous controls




Genotype
MGI:2662818
hm9
Allelic
Composition
Foxn1nu/Foxn1nu
Genetic
Background
involves: NMRI
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxn1nu mutation (43 available); any Foxn1 mutation (96 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
integument
• sulfur content of the hair fibers is reduced
• hair shafts from the flank show multiple fractures, are twisted, crippled and bent, and locally thickened by numerous fusiform bulges
• hair shafts below the epidermis are composed of globular and discontinuous conglomerates of horny material
• most shafts fail to reach the epidermal surface and those that do are weak and fragile
• pigment granules are only randomly detected in the hair cortex
• missing irregularly in the zone of final hardening
• the cortex of the intrafollicular part of the hair shaft is always fragmented into globular and irregularly formed aggregates and includes unusual filamentous substances
• missing irregularly in the zone of final hardening
• occupied by abnormal globular aggregates
• either discontinuous or more frequently totally absent
• there is a prominent granular layer between the upper layers of the stratum spinosum and the nail plate
• the nail bed epithelium does not appear to be abnormal
• the matrix region is severely altered
• some suprabasal cells show increased cytoplasm often associated with multiple intracytoplasmic vacuoles
• keratinocytes high in the spinous layer show striped cytoplasm
• the matrix zone is thinner and extends farther toward the distal tip of the nail
• the ventral epithelium of the proximal nail fold and the suprabasal cells of the nail matrix lack keratin 1 immunoreactivity and show abnormal expression of filaggrin
• keratohyalin granules of irregular size and shape are present in the cytoplasm of the suprabasal keratinocytes and insert into the aggregated tonofilaments disturbing filament aggregation
• sulfur content of the nail plate is reduced
• the nail plate is compact and narrows toward the tip of the nail
• the nail plate is markedly thinner at both the proximal nail fold and the tip of the nail
• nail plates consist of smaller, elongated superficial squames with slightly irregular surfaces and serrated borders
• the nail plate appears basophilic
• the dorsal nail plate separates from the hyponychium but bends toward the ventral side and breaks off
• blunt, broken, irregularly formed ends
• severely shortened nails
• in most mice the nails terminate at the junction of the nail plate and the hyponychium
• hair follicles in the zone of final hardening show pronounced pathological changes
• however, the number of hair bulbs is similar to controls
• missing irregularly in the zone of final hardening
• fibrils are more tightly packed than in controls
• half-desmosomes attaching basal cells to the subjacent basal lamina are irregularly spaced with only scantly tonofilaments attached to them
• cells contain only few and small bundles of tonofilaments
• highly irregular, with areas of large piles of horny substances and projected corneocytes alternated with regions of only few and extremely attenuated corneous layers
• the lamellae are irregularly shaped and detached from one another, with intercellular contact lost over large areas
• the layer is loosened with increased distance from the granular layer
• the skin surface looks rough because of bizarrely formed and projected corneocytes
• the interior of the corneocytes has an inhomogeneous appearance
• markedly reduced number and thickness of tonofilament bundles

embryo
• the cervical duct has not narrowed and the third cleft covers only the dorsal part of the third branchial pouch at E1.5
• the ectoderm of the third cleft covers only the distal extremity and a small part of the cranial and caudal walls of the third pouch at E11.5
• at the end of the 11th day the pharyngo-branchial duct is reduced to a thin cord of cells that later disappears and the cervical duct also degenerates

endocrine/exocrine glands
N
• the structure of the parathyroid is identical to controls at E16 and E17
• at E12 the ectoderm covers only the mid-portion of the ventral and external surfaces of the endoderm
• at E12.5 the primitive thymus is essentially endodermal with the ectodermal portion confined to the cranial region
• between E12 and E14 the volume of the thymus merely doubles rather than growing exponentially as in controls and the epithelial mass does not increase from E14 to E16
• at no time is the epithelium invaded by lymphoid cells

immune system
• at E12 the ectoderm covers only the mid-portion of the ventral and external surfaces of the endoderm
• at E12.5 the primitive thymus is essentially endodermal with the ectodermal portion confined to the cranial region
• between E12 and E14 the volume of the thymus merely doubles rather than growing exponentially as in controls and the epithelial mass does not increase from E14 to E16
• at no time is the epithelium invaded by lymphoid cells

pigmentation
• pigment granules are only randomly detected in the hair cortex

hematopoietic system
• at E12 the ectoderm covers only the mid-portion of the ventral and external surfaces of the endoderm
• at E12.5 the primitive thymus is essentially endodermal with the ectodermal portion confined to the cranial region
• between E12 and E14 the volume of the thymus merely doubles rather than growing exponentially as in controls and the epithelial mass does not increase from E14 to E16
• at no time is the epithelium invaded by lymphoid cells




Genotype
MGI:2680668
hm10
Allelic
Composition
Foxn1nu/Foxn1nu
Genetic
Background
Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxn1nu mutation (43 available); any Foxn1 mutation (96 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• 100% mortality by 25 weeks (J:5043)
• most die within a few weeks of weaning (J:30772)
• some mice die within 1 week of birth
• 55% mortality within 2 weeks

endocrine/exocrine glands
• a much smaller and dorsoventrally flattened thymic rudiment is present at E14-E15
• a thymic rudiment comprised of vesicles and lacking lymphoid cells is present at P1-P2

growth/size/body

liver/biliary system
• liver lobes were atrophied and covered with red scars
• variable degrees of severity, typically increasing with age at time of death

reproductive system
• many sperm had coiled tails
• many females exhibited continuous dioestrus and metaoestrus phases
• severely reduced fertility

immune system
• a much smaller and dorsoventrally flattened thymic rudiment is present at E14-E15
• a thymic rudiment comprised of vesicles and lacking lymphoid cells is present at P1-P2
• the proportion of red to white pulp is greater than normal
• in some cases the Malpighian follicles are present but are fewer in number and smaller than in controls
• in some cases an unusually high number of megakaryocytes is seen in the red pulp
• virtual absence of small lymphocytes in the thymus dependent area and the post-capillary venules are often thin walled and empty

integument
• sparse hair growth around 5 weeks of age (J:5043)
• in some mice, cephalo-caudal migration of an irregular band of short sparse hair (J:5043)
• mice fail to grow a first coat of hair (J:30772)
• absent at birth
• older mice show repeated growth and loss of short and wavy vibrissae
• older mice show repeated growth and loss of short and wavy vibrissae
• reduction in skin thickness at 3 weeks of age, corresponding to the catagen stage of normal skin

behavior/neurological
• longer latency during the acquisition and reversal phases in a Morris water maze
• in the extinction phase spend more time in the training quadrant and are less able to recall data from the previous day's training
• replenishing mice with T cells from wild-type mice improves performance in a Morris water maze

cardiovascular system
• in the thymus dependent area of the lymph nodes the post-capillary venules are often thin walled and empty

hematopoietic system
• a much smaller and dorsoventrally flattened thymic rudiment is present at E14-E15
• a thymic rudiment comprised of vesicles and lacking lymphoid cells is present at P1-P2
• the proportion of red to white pulp is greater than normal
• in some cases the Malpighian follicles are present but are fewer in number and smaller than in controls
• in some cases an unusually high number of megakaryocytes is seen in the red pulp

cellular
• many sperm had coiled tails




Genotype
MGI:5521192
hm11
Allelic
Composition
Foxn1nu/Foxn1nu
Genetic
Background
NU/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxn1nu mutation (43 available); any Foxn1 mutation (96 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
integument
• there is a prominent granular layer between the upper layers of the stratum spinosum and the nail plate
• the nail bed epithelium does not appear to be abnormal
• the matrix region is severely altered
• some suprabasal cells show increased cytoplasm often associated with multiple intracytoplasmic vacuoles
• keratinocytes high in the spinous layer show striped cytoplasm
• the matrix zone is thinner and extends farther toward the distal tip of the nail
• the ventral epithelium of the proximal nail fold and the suprabasal cells of the nail matrix lack keratin 1 immunoreactivity and show abnormal expression of filaggrin
• keratohyalin granules of irregular size and shape are present in the cytoplasm of the suprabasal keratinocytes and insert into the aggregated tonofilaments disturbing filament aggregation
• the nail plate appears basophilic
• the dorsal nail plate separates from the hyponychium but bends toward the ventral side and breaks off




Genotype
MGI:5521303
ht12
Allelic
Composition
Foxn1nu/Foxn1+
Genetic
Background
B6N.Cg-Foxn1nu
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxn1nu mutation (43 available); any Foxn1 mutation (96 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system

hematopoietic system

endocrine/exocrine glands




Genotype
MGI:5521305
ht13
Allelic
Composition
Foxn1nu/Foxn1+
Genetic
Background
C3N.Cg-Foxn1nu
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxn1nu mutation (43 available); any Foxn1 mutation (96 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system

hematopoietic system

endocrine/exocrine glands




Genotype
MGI:3848173
ht14
Allelic
Composition
Foxn1nu/Foxn1+
Genetic
Background
C.Cg-Foxn1nu
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxn1nu mutation (43 available); any Foxn1 mutation (96 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system

hematopoietic system

endocrine/exocrine glands




Genotype
MGI:5521193
ht15
Allelic
Composition
Foxn1nu/Foxn1+
Genetic
Background
involves: BALB/c
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxn1nu mutation (43 available); any Foxn1 mutation (96 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• more severe and lasting longer following infection with HSV-1 strain CJ394 compared to controls
• develop stromal keratitis 8 days after infection with HSV-1 strain CJ394 while homozygous and wild-type mice display only slight corneal cloudiness
• following infection with HSV-1 strain CJ394 young mice (7-10 weeks of age) develop more severe ocular disease and develop severe extra ocular disease not seen in controls
• extraocular disease is less severe than in homozygous mice
• extensive herpetiform spread is seen, in some cases the tissue damage is so severe that the skull is exposed

vision/eye
• detected 8 to 14 days after infection with HSV-1 strain CJ394in heterozygotes but not in wild-type or homozygous mice
• more severe and lasting longer following infection with HSV-1 strain CJ394 compared to controls
• develop stromal keratitis 8 days after infection with HSV-1 strain CJ394 while homozygous and wild-type mice display only slight corneal cloudiness

cardiovascular system
• detected 8 to 14 days after infection with HSV-1 strain CJ394in heterozygotes but not in wild-type or homozygous mice




Genotype
MGI:5521298
ht16
Allelic
Composition
Foxn1nu/Foxn1+
Genetic
Background
NFS.Cg-Foxn1nu
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxn1nu mutation (43 available); any Foxn1 mutation (96 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• thymus lobes are rimmed to a varying degree with brown fat tissue and often asymmetrical in shape
• lobes are significantly smaller at P7 and P14
• difference in size compared to wild-type controls increases with age

hematopoietic system
• thymus lobes are rimmed to a varying degree with brown fat tissue and often asymmetrical in shape
• lobes are significantly smaller at P7 and P14
• difference in size compared to wild-type controls increases with age

endocrine/exocrine glands
• thymus lobes are rimmed to a varying degree with brown fat tissue and often asymmetrical in shape
• lobes are significantly smaller at P7 and P14
• difference in size compared to wild-type controls increases with age




Genotype
MGI:4454658
cn17
Allelic
Composition
Foxn1nu/Foxn1tm1.1Dmsu
Tg(CAG-cre/Esr1*)5Amc/0
Genetic
Background
involves: 129/Sv * C57BL/6 * CBA * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxn1nu mutation (43 available); any Foxn1 mutation (96 available)
Foxn1tm1.1Dmsu mutation (1 available); any Foxn1 mutation (96 available)
Tg(CAG-cre/Esr1*)5Amc mutation (8 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• following tamoxifen treatment, mature medullary thymic epithelial cells undergo increased apoptosis compared to in wild-type mice
• following tamoxifen treatment, medullary thymic epithelial cells are reduced compared to in wild-type mice
• mature medullary thymic epithelial cells are more affected than presumptive medullary thymic epithelial cell precursors following tamoxifen treatment
• however, cortical thymic epithelial cells are not significantly reduced following tamoxifen treatment
• following tamoxifen treatment

hematopoietic system
• following tamoxifen treatment, mature medullary thymic epithelial cells undergo increased apoptosis compared to in wild-type mice
• following tamoxifen treatment, medullary thymic epithelial cells are reduced compared to in wild-type mice
• mature medullary thymic epithelial cells are more affected than presumptive medullary thymic epithelial cell precursors following tamoxifen treatment
• however, cortical thymic epithelial cells are not significantly reduced following tamoxifen treatment
• following tamoxifen treatment

cellular
• following tamoxifen treatment, mature medullary thymic epithelial cells undergo increased apoptosis compared to in wild-type mice

endocrine/exocrine glands
• following tamoxifen treatment, mature medullary thymic epithelial cells undergo increased apoptosis compared to in wild-type mice
• following tamoxifen treatment, medullary thymic epithelial cells are reduced compared to in wild-type mice
• mature medullary thymic epithelial cells are more affected than presumptive medullary thymic epithelial cell precursors following tamoxifen treatment
• however, cortical thymic epithelial cells are not significantly reduced following tamoxifen treatment
• following tamoxifen treatment




Genotype
MGI:3622470
cx18
Allelic
Composition
Foxn1nu/Foxn1nu
Tgfb1tm1Doe/Tgfb1tm1Doe
Genetic
Background
involves: 129S2/SvPas * BALB/c * CF-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxn1nu mutation (43 available); any Foxn1 mutation (96 available)
Tgfb1tm1Doe mutation (4 available); any Tgfb1 mutation (26 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• double mutants survive beyond 2 months compared to 21 days for Tgfb1 null mice (3-4 month increase in longevity)

immune system
• animals have a severe reduction of CD4+ and CD8+ T cells
• organ inflammation is prevented compared to single mutants

hematopoietic system
• animals have a severe reduction of CD4+ and CD8+ T cells




Genotype
MGI:3583342
cx19
Allelic
Composition
Foxn1nu/Foxn1nu
Ivltm1Dji/Ivltm1Dji
Genetic
Background
involves: 129S4/SvJae * BALB/c * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxn1nu mutation (43 available); any Foxn1 mutation (96 available)
Ivltm1Dji mutation (0 available); any Ivl mutation (16 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
normal phenotype




Genotype
MGI:5521205
cx20
Allelic
Composition
Foxn1nu/Foxn1nu
Msx2tm1Rilm/Msx2tm1Rilm
Genetic
Background
involves: 129S4/SvJae * BALB/c * CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxn1nu mutation (43 available); any Foxn1 mutation (96 available)
Msx2tm1Rilm mutation (1 available); any Msx2 mutation (22 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
integument
• nail phenotype is 100% penetrant
• hyperplastic with multiple layers of cells with no visible transition from nail matrix to nail bed
• distal matrix hyperproliferation
• rugged surface with irregular squames
• broken with blunt ends
• break beyond the hyponychium
• break is more proximal than in Foxn1nu single mutants




Genotype
MGI:6446219
cx21
Allelic
Composition
Btnl1tm1(KOMP)Mbp/Btnl1tm1(KOMP)Mbp
Foxn1nu/Foxn1nu
Genetic
Background
involves: albino stock * C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Btnl1tm1(KOMP)Mbp mutation (2 available); any Btnl1 mutation (21 available)
Foxn1nu mutation (43 available); any Foxn1 mutation (96 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• 90% loss of TCRVgamma7+ intraepithelial lymphocytes (IELs) in the gut
• almost total loss of TCRVgamma7GL2+ IELs in the gut

immune system
• 90% loss of TCRVgamma7+ intraepithelial lymphocytes (IELs) in the gut
• almost total loss of TCRVgamma7GL2+ IELs in the gut




Genotype
MGI:3505597
cx22
Allelic
Composition
Foxn1nu/Foxn1nu
Fv4r/Fv4r
Genetic
Background
involves: BALB/c
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxn1nu mutation (43 available); any Foxn1 mutation (96 available)
Fv4r mutation (2 available); any Fv4 mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• almost completely suppresses growth of ecotropic MuLV and MuSv (J:5714)
• does not develop ecotropic virus-induced splenomegaly or focal lesions on spleen (J:5684)




Genotype
MGI:4361561
cx23
Allelic
Composition
Foxn1nu/Foxn1nu
Map3k14aly/Map3k14aly
Genetic
Background
involves: BALB/cAJcl * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxn1nu mutation (43 available); any Foxn1 mutation (96 available)
Map3k14aly mutation (3 available); any Map3k14 mutation (30 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• small intestines lack IgA+ B cells unlike in wild-type mice
• mature T cells are virtually absent
• gamma-delta intraepithelial T cell are decreased by a factor of 2 compared to in Foxn1nu homozygotes
• however, gamma-delta intraepithelial T cells colonize the intestinal epithelia

hematopoietic system
• small intestines lack IgA+ B cells unlike in wild-type mice
• mature T cells are virtually absent
• gamma-delta intraepithelial T cell are decreased by a factor of 2 compared to in Foxn1nu homozygotes
• however, gamma-delta intraepithelial T cells colonize the intestinal epithelia

endocrine/exocrine glands




Genotype
MGI:3045968
cx24
Allelic
Composition
Foxn1nu/Foxn1nu
Srcr/Srcr+
Genetic
Background
involves: BALB/c * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxn1nu mutation (43 available); any Foxn1 mutation (96 available)
Srcr mutation (0 available); any Srcr mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
• injection of tumor forming cells does not result in tumor formation or results in tumor formation followed by spontaneous regression




Genotype
MGI:5521335
cx25
Allelic
Composition
Dmdmdx/Y
Foxn1nu/Foxn1nu
Genetic
Background
involves: C57BL/10ScSn
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dmdmdx mutation (28 available); any Dmd mutation (151 available)
Foxn1nu mutation (43 available); any Foxn1 mutation (96 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
muscle
• elevated hydroxyproline levels in the heart, tibialis anterior and soleus when normalized to wet weight but not on a per muscle basis in mice at 3 weeks of age but not at 24 weeks of age
• unlike in mice homozygous for Dmdmdx alone, necrosis has not started at 3 weeks of age
• in the tibialis anterior at 3 weeks of age
• in the soleus muscles at 3 weeks of age




Genotype
MGI:2174844
cx26
Allelic
Composition
Foxn1nu/Foxn1nu
Tg(Foxn1)G2Hon/0
Genetic
Background
involves: CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxn1nu mutation (43 available); any Foxn1 mutation (96 available)
Tg(Foxn1)G2Hon mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
reproductive system

integument
• hair density reduced by ~80%
• normal hair length and overall body coverage




Genotype
MGI:3798863
cx27
Allelic
Composition
Foxn1nu/Foxn1nu
Gpc1tm1.1Alan/Gpc1tm1.1Alan
Genetic
Background
involves: CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxn1nu mutation (43 available); any Foxn1 mutation (96 available)
Gpc1tm1.1Alan mutation (2 available); any Gpc1 mutation (23 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
• athymic mutants exhibit decreased tumor angiogenesis and metastasis following intrapancreatic implantation with either PANC-1 or T3M4 human pancreatic cancer cells and fewer pulmonary metastates following intravenous injection of murine B16-F10 melanoma cells

homeostasis/metabolism
• isolated hepatic endothelial cells exhibit an attenuated mitogenic response to VEGF-A, with cells showing a smaller increase in cell proliferation than wild-type in response to VEGF-A




Genotype
MGI:2174843
cx28
Allelic
Composition
Foxn1nu/Foxn1nu
Tg(Foxn1)E1Hon/0
Genetic
Background
involves: CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxn1nu mutation (43 available); any Foxn1 mutation (96 available)
Tg(Foxn1)E1Hon mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system

hematopoietic system

integument
• hair density reduced by ~50%
• normal hair length and overall body coverage

endocrine/exocrine glands




Genotype
MGI:3819387
cx29
Allelic
Composition
Dh/Dh+
Foxn1nu/Foxn1nu
Genetic
Background
involves: N:NIH(S)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dh mutation (1 available); any Dh mutation (1 available)
Foxn1nu mutation (43 available); any Foxn1 mutation (96 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• demonstrated in culture

immune system
• increased histiocytic engorgement observed in this genotype

endocrine/exocrine glands





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/27/2022
MGI 6.21
The Jackson Laboratory