Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mitfmi-sp mutation
(10 available);
any
Mitf mutation
(72 available)
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pigmentation
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N |
• homozygotes have a normal appearance since the mutation is only visibly evident in compound heterozygotes
(J:12946)
• the number, kind, and arrangement of cortical pigment granules in the hair is normal
(J:12946)
(J:35685)
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• despite the normal black coat color, homozygotes have reduced tyrosinase activity as evidenced by reduced incorporation of radiolabeled tyrosine into skin slices from 5 day old homozygotes
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pigmentation
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• compound heterozygotes are pale yellow with well demarcated white spots on both the dorsum and ventrum
(J:12946)
• at the first moult the hairs that had initially been pale yellow become sooty in color
(J:12946)
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• medullary granules vary greatly in size and shape and are less dense than wild-type
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• the tail, feet, and ears are largely unpigmented although the eyes have pigment
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craniofacial
hearing/vestibular/ear
limbs/digits/tail
integument
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• compound heterozygotes are pale yellow with well demarcated white spots on both the dorsum and ventrum
(J:12946)
• at the first moult the hairs that had initially been pale yellow become sooty in color
(J:12946)
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• medullary granules vary greatly in size and shape and are less dense than wild-type
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• the tail, feet, and ears are largely unpigmented although the eyes have pigment
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growth/size/body
pigmentation
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• by backcross generation N5 the coat color is all white with all hair devoid of pigment
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vision/eye
integument
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• by backcross generation N5 the coat color is all white with all hair devoid of pigment
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pigmentation
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• Background Sensitivity: prior to backcross generation N5 on the C57BL/6J background mice are white except for a variable number of faint irregular pigment patches; the faint dorsal pigmentation is lost with further backcrossing
(J:12946)
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vision/eye
Analysis Tools