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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Mitfmi-bw
black eyed white
MGI:1856089
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Mitfmi-bw/Mitfmi-bw involves: C3H MGI:3521811
cx2
Mitfmi-bw/Mitfmi-bw
Tg(Dct-lacZ)A12Jkn/0
involves: C3H * C57BL/6 * C57BL/6J * CBA MGI:5635983


Genotype
MGI:3521811
hm1
Allelic
Composition
Mitfmi-bw/Mitfmi-bw
Genetic
Background
involves: C3H
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mitfmi-bw mutation (3 available); any Mitf mutation (65 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
pigmentation
• mice are white with, infrequently, a few pigmented hairs on the back

hearing/vestibular/ear
• stria vascularis was abnormally thin

integument
• mice are white with, infrequently, a few pigmented hairs on the back




Genotype
MGI:5635983
cx2
Allelic
Composition
Mitfmi-bw/Mitfmi-bw
Tg(Dct-lacZ)A12Jkn/0
Genetic
Background
involves: C3H * C57BL/6 * C57BL/6J * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mitfmi-bw mutation (3 available); any Mitf mutation (65 available)
Tg(Dct-lacZ)A12Jkn mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
pigmentation
• white coat color, however eyes are black
• no melanocytes are seen in the hair follicles

embryo
• in neural tube cultures, melanoblasts are unable to migrate out from the neural tube
• decrease in the number of melanoblasts between E12.5 and E13.5, with absence of melanoblasts in the trunk region at E13.5
• increase in melanoblast apoptosis at E12.5

integument
• white coat color, however eyes are black

nervous system
• decrease in the number of melanoblasts between E12.5 and E13.5, with absence of melanoblasts in the trunk region at E13.5
• increase in melanoblast apoptosis at E12.5

cellular
• in neural tube cultures, melanoblasts are unable to migrate out from the neural tube

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
Waardenburg syndrome type 2A DOID:0110950 OMIM:193510
J:213982





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/23/2021
MGI 6.17
The Jackson Laboratory