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Allele Symbol Allele Name Allele ID |
Atrnmg-3J mahogany 3 Jackson MGI:1856082 |
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| Summary |
7 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice exhibit widespread vacuolation at 3 moths and extensive vacuolation at 6 months
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• mice exhibit a black coat color
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• mice exhibit a black coat color
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• reduced levels of pheomelanin and 20-30% reductions in eumelanin between 5 and 11 months of age
• lacks yellow bands in hair
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• yellow pigment is completely absent resulting in a black coat
(J:81466)
• mahogany coat
(J:96070)
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• observed in a few mutants, characterized by a sudden freezing of motion followed by toppling over onto the side and did not progress to tonic-clonic convulsive activity
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• vacuoles in all regions of the CNS by 1 month of age
(J:71075)
• vacuolation becomes exaggerated with increasing age
(J:71075)
• most vacuoles in the gray matter of 6-month old mutants are membrane bound, not enclosed by myelin sheaths, and appear to originate from dendrites or astrocytic processes
(J:81466)
• vacuoles in the brain
(J:96070)
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• by 11 to 12 months of age, many brain regions exhibit moderate to severe astrocytosis
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• age-dependent progression of spongiform degeneration
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• males weigh 10-15% less than controls by 3 months of age
• female weights are not significantly lower than controls until 4 months of age
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• 20-40% reduction in body fat
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• nocturnal locomotor activity is elevated 20-30%
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• observed in a few mutants, characterized by a sudden freezing of motion followed by toppling over onto the side and did not progress to tonic-clonic convulsive activity
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• reduced levels of pheomelanin and 20-30% reductions in eumelanin between 5 and 11 months of age
• lacks yellow bands in hair
|
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• yellow pigment is completely absent resulting in a black coat
(J:81466)
• mahogany coat
(J:96070)
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• at 2 months of age there is significant vacuolation in all brain regions examined, which is not altered in severity by the addition of one or two alleles of the dark-like mutation
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice develop progressive vacuolation of the brain similar to Atrnmg-3J homozygotes
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• by 6 months of age some mice develop cardiomyopathy
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• by 6 months of age some mice develop cardiomyopathy
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice homozygous for dark-like and heterozgyous for the mahogany 3 Jackson allele of attractin have a darker coat color than mice homozygous for dark-like and wildtype for attractin
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• mice homozygous for dark-like and heterozgyous for the mahogany 3 Jackson allele of attractin have a darker coat color than mice homozygous for dark-like and wildtype for attractin
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• at 3 months of age 13 out of 17 mice homozygous for dark-like on this background display significant vacuolation in the testes regardless of whether they are heterozgyous or wild-type for the mahogany 3 Jackson allele, and at 6 months of age this is increased to 9 out of 10 assessed
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• at 3 months of age 13 out of 17 mice homozygous for dark-like on this background display significant vacuolation in the testes regardless of whether they are heterozgyous or wild-type for the mahogany 3 Jackson allele, and at 6 months of age this is increased to 9 out of 10 assessed
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• at 2-3 months of age no vacuoles are found in compound heterozgyotes, 2 of 5 dark-like homozygotes wild-type for attractin have vacuolation in multiple brain regions, while dark-like homozygotes heterozygous for mahogany 3 Jackson have a range of CNS vacuolation from undetectable to severe
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• indicative of an additive interaction of these alleles, both of two compound heterozygotes assessed at 3 months of age and 5 of 9 assessed at 6 months of age display vacuolation in the testes, although to a lesser degree than is found in dark-like homozygotes
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• indicative of an additive interaction of these alleles, both of two compound heterozygotes assessed at 3 months of age and 5 of 9 assessed at 6 months of age display vacuolation in the testes, although to a lesser degree than is found in dark-like homozygotes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• brain vacuolation is rescued with only sparse, scattered vacuoles observed at 3 months
• mild to moderate vacuolation occurs at 6 months
• Background Sensitivity: rescue of vacuolation occurs on both a C3H/HeJ and C57BL/6J background
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• mice exhibit a partially rescued coat color that is described as dark agouti
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• mice exhibit a partially rescued coat color that is described as dark agouti
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/16/2024 MGI 6.23 |
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