About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Atrnmg-3J
mahogany 3 Jackson
MGI:1856082
Summary 7 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Atrnmg-3J/Atrnmg-3J C3HeB/FeJ-Atrnmg-3J MGI:3773149
hm2
Atrnmg-3J/Atrnmg-3J C3HeB/FeJ-Atrnmg-3J/J MGI:3575834
hm3
Atrnmg-3J/Atrnmg-3J involves: C3H/HeJ * C3HeB/FeJ * CBA/J MGI:5605681
cx4
Atrnmg-3J/Atrnmg-3J
Atrnl1tm1Gsb/Atrnl1tm1Gsb
involves: 129S1/Sv * 129X1/SvJ * C3H * C3HeB/FeJ MGI:3773151
cx5
Atrnmg-3J/Atrn+
Pepddal/Pepddal
involves: C3H/HeJ * C3HeB/FeJ * CBA/J MGI:5605670
cx6
Atrnmg-3J/Atrn+
Pepddal/Pepd+
involves: C3H/HeJ * C3HeB/FeJ * CBA/J MGI:5605679
cx7
Atrnmg-3J/Atrnmg-3J
Tg(ACTB-Atrnl1)B4Tmg/0
involves: C3HeB/FeJ * C57BL/6 * DBA/2 MGI:3773148


Genotype
MGI:3773149
hm1
Allelic
Composition
Atrnmg-3J/Atrnmg-3J
Genetic
Background
C3HeB/FeJ-Atrnmg-3J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atrnmg-3J mutation (2 available); any Atrn mutation (65 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• mice exhibit widespread vacuolation at 3 moths and extensive vacuolation at 6 months

pigmentation
• mice exhibit a black coat color

integument
• mice exhibit a black coat color




Genotype
MGI:3575834
hm2
Allelic
Composition
Atrnmg-3J/Atrnmg-3J
Genetic
Background
C3HeB/FeJ-Atrnmg-3J/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atrnmg-3J mutation (2 available); any Atrn mutation (65 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
pigmentation
• reduced levels of pheomelanin and 20-30% reductions in eumelanin between 5 and 11 months of age
• lacks yellow bands in hair
• yellow pigment is completely absent resulting in a black coat (J:81466)
• mahogany coat (J:96070)

nervous system
• observed in a few mutants, characterized by a sudden freezing of motion followed by toppling over onto the side and did not progress to tonic-clonic convulsive activity
• vacuoles in all regions of the CNS by 1 month of age (J:71075)
• vacuolation becomes exaggerated with increasing age (J:71075)
• most vacuoles in the gray matter of 6-month old mutants are membrane bound, not enclosed by myelin sheaths, and appear to originate from dendrites or astrocytic processes (J:81466)
• vacuoles in the brain (J:96070)
• by 11 to 12 months of age, many brain regions exhibit moderate to severe astrocytosis
• age-dependent progression of spongiform degeneration

growth/size/body
• males weigh 10-15% less than controls by 3 months of age
• female weights are not significantly lower than controls until 4 months of age

adipose tissue
• 20-40% reduction in body fat

behavior/neurological
• nocturnal locomotor activity is elevated 20-30%
• observed in a few mutants, characterized by a sudden freezing of motion followed by toppling over onto the side and did not progress to tonic-clonic convulsive activity

muscle

integument
• reduced levels of pheomelanin and 20-30% reductions in eumelanin between 5 and 11 months of age
• lacks yellow bands in hair
• yellow pigment is completely absent resulting in a black coat (J:81466)
• mahogany coat (J:96070)




Genotype
MGI:5605681
hm3
Allelic
Composition
Atrnmg-3J/Atrnmg-3J
Genetic
Background
involves: C3H/HeJ * C3HeB/FeJ * CBA/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atrnmg-3J mutation (2 available); any Atrn mutation (65 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• at 2 months of age there is significant vacuolation in all brain regions examined, which is not altered in severity by the addition of one or two alleles of the dark-like mutation




Genotype
MGI:3773151
cx4
Allelic
Composition
Atrnmg-3J/Atrnmg-3J
Atrnl1tm1Gsb/Atrnl1tm1Gsb
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C3H * C3HeB/FeJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atrnl1tm1Gsb mutation (0 available); any Atrnl1 mutation (37 available)
Atrnmg-3J mutation (2 available); any Atrn mutation (65 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• mice develop progressive vacuolation of the brain similar to Atrnmg-3J homozygotes

cardiovascular system
• by 6 months of age some mice develop cardiomyopathy

muscle
• by 6 months of age some mice develop cardiomyopathy




Genotype
MGI:5605670
cx5
Allelic
Composition
Atrnmg-3J/Atrn+
Pepddal/Pepddal
Genetic
Background
involves: C3H/HeJ * C3HeB/FeJ * CBA/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atrnmg-3J mutation (2 available); any Atrn mutation (65 available)
Pepddal mutation (1 available); any Pepd mutation (25 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
integument
• mice homozygous for dark-like and heterozgyous for the mahogany 3 Jackson allele of attractin have a darker coat color than mice homozygous for dark-like and wildtype for attractin

pigmentation
• mice homozygous for dark-like and heterozgyous for the mahogany 3 Jackson allele of attractin have a darker coat color than mice homozygous for dark-like and wildtype for attractin

endocrine/exocrine glands
• at 3 months of age 13 out of 17 mice homozygous for dark-like on this background display significant vacuolation in the testes regardless of whether they are heterozgyous or wild-type for the mahogany 3 Jackson allele, and at 6 months of age this is increased to 9 out of 10 assessed

reproductive system
• at 3 months of age 13 out of 17 mice homozygous for dark-like on this background display significant vacuolation in the testes regardless of whether they are heterozgyous or wild-type for the mahogany 3 Jackson allele, and at 6 months of age this is increased to 9 out of 10 assessed

nervous system
• at 2-3 months of age no vacuoles are found in compound heterozgyotes, 2 of 5 dark-like homozygotes wild-type for attractin have vacuolation in multiple brain regions, while dark-like homozygotes heterozygous for mahogany 3 Jackson have a range of CNS vacuolation from undetectable to severe




Genotype
MGI:5605679
cx6
Allelic
Composition
Atrnmg-3J/Atrn+
Pepddal/Pepd+
Genetic
Background
involves: C3H/HeJ * C3HeB/FeJ * CBA/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atrnmg-3J mutation (2 available); any Atrn mutation (65 available)
Pepddal mutation (1 available); any Pepd mutation (25 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands
• indicative of an additive interaction of these alleles, both of two compound heterozygotes assessed at 3 months of age and 5 of 9 assessed at 6 months of age display vacuolation in the testes, although to a lesser degree than is found in dark-like homozygotes

reproductive system
• indicative of an additive interaction of these alleles, both of two compound heterozygotes assessed at 3 months of age and 5 of 9 assessed at 6 months of age display vacuolation in the testes, although to a lesser degree than is found in dark-like homozygotes




Genotype
MGI:3773148
cx7
Allelic
Composition
Atrnmg-3J/Atrnmg-3J
Tg(ACTB-Atrnl1)B4Tmg/0
Genetic
Background
involves: C3HeB/FeJ * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atrnmg-3J mutation (2 available); any Atrn mutation (65 available)
Tg(ACTB-Atrnl1)B4Tmg mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• brain vacuolation is rescued with only sparse, scattered vacuoles observed at 3 months
• mild to moderate vacuolation occurs at 6 months
• Background Sensitivity: rescue of vacuolation occurs on both a C3H/HeJ and C57BL/6J background

pigmentation
• mice exhibit a partially rescued coat color that is described as dark agouti

integument
• mice exhibit a partially rescued coat color that is described as dark agouti





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
01/18/2022
MGI 6.17
The Jackson Laboratory