Phenotypes associated with this allele
Allelic Composition |
Myo5ad/Myo5ad
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Genetic Background |
involves: C57BL/6J |
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myo5ad mutation
(105 available);
any
Myo5a mutation
(265 available)
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pigmentation
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• cultured primary melanocytes display clustering of melanosomes but are otherwise normal
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myo5ad mutation
(105 available);
any
Myo5a mutation
(265 available)
Myo5ad-84H mutation
(0 available);
any
Myo5a mutation
(265 available)
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integument
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• resembles Myo5ad homozygotes
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pigmentation
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• resembles Myo5ad homozygotes
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Allelic Composition |
Myo5ad/Myo5ad-51H
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Genetic Background |
involves: 101/H * C3H/HeH |
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myo5ad mutation
(105 available);
any
Myo5a mutation
(265 available)
Myo5ad-51H mutation
(0 available);
any
Myo5a mutation
(265 available)
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integument
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• resembles Myo5ad homozygotes
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pigmentation
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• resembles Myo5ad homozygotes
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Allelic Composition |
Myo5ad/Myo5ad-52H
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Genetic Background |
involves: 101/H * C3H/HeH |
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myo5ad mutation
(105 available);
any
Myo5a mutation
(265 available)
Myo5ad-52H mutation
(0 available);
any
Myo5a mutation
(265 available)
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integument
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• resembles Myo5ad homozygotes
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pigmentation
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• resembles Myo5ad homozygotes
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Allelic Composition |
Myo5ad/Myo5ad-53H
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Genetic Background |
involves: 101/H * C3H/HeH |
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myo5ad mutation
(105 available);
any
Myo5a mutation
(265 available)
Myo5ad-53H mutation
(0 available);
any
Myo5a mutation
(265 available)
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integument
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• resembles Myo5ad homozygotes
|
pigmentation
|
• resembles Myo5ad homozygotes
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Allelic Composition |
Myo5ad/Myo5ad-78H
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Genetic Background |
involves: 101/H * C3H/HeH |
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myo5ad mutation
(105 available);
any
Myo5a mutation
(265 available)
Myo5ad-78H mutation
(0 available);
any
Myo5a mutation
(265 available)
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integument
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• resembles Myo5ad homozygotes
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pigmentation
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• resembles Myo5ad homozygotes
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Allelic Composition |
Myo5ad/Myo5ad-80H
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Genetic Background |
involves: 101/H * C3H/HeH |
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myo5ad mutation
(105 available);
any
Myo5a mutation
(265 available)
Myo5ad-80H mutation
(0 available);
any
Myo5a mutation
(265 available)
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integument
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• resembles Myo5ad homozygotes
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pigmentation
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• resembles Myo5ad homozygotes
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Allelic Composition |
Myo5ad/Myo5ad-82H
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Genetic Background |
involves: 101/H * C3H/HeH |
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myo5ad mutation
(105 available);
any
Myo5a mutation
(265 available)
Myo5ad-82H mutation
(0 available);
any
Myo5a mutation
(265 available)
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integument
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• resembles Myo5ad homozygotes
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pigmentation
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• resembles Myo5ad homozygotes
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Allelic Composition |
Myo5ad/Myo5ad-86H
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Genetic Background |
involves: 101/H * C3H/HeH |
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myo5ad mutation
(105 available);
any
Myo5a mutation
(265 available)
Myo5ad-86H mutation
(0 available);
any
Myo5a mutation
(265 available)
|
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integument
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• resembles Myo5ad homozygotes
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pigmentation
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• resembles Myo5ad homozygotes
|
Allelic Composition |
Myo5ad/Myo5ad-97H
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Genetic Background |
involves: 101/H * C3H/HeH |
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myo5ad mutation
(105 available);
any
Myo5a mutation
(265 available)
Myo5ad-97H mutation
(0 available);
any
Myo5a mutation
(265 available)
|
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Allelic Composition |
Myo5ad/Myo5ad-93H
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Genetic Background |
involves: 101/H * C3H/HeH |
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myo5ad mutation
(105 available);
any
Myo5a mutation
(265 available)
Myo5ad-93H mutation
(0 available);
any
Myo5a mutation
(265 available)
|
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integument
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• resembles Myo5ad homozygotes
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pigmentation
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• resembles Myo5ad homozygotes
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myo5ad mutation
(105 available);
any
Myo5a mutation
(265 available)
Myo5ad-105H mutation
(0 available);
any
Myo5a mutation
(265 available)
|
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Allelic Composition |
Myo5ad/Myo5ad-85H
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Genetic Background |
involves: 101/H * C3H/HeH |
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myo5ad mutation
(105 available);
any
Myo5a mutation
(265 available)
Myo5ad-85H mutation
(0 available);
any
Myo5a mutation
(265 available)
|
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integument
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• mice resemble Myo5ad homozygotes
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pigmentation
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• mice resemble Myo5ad homozygotes
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Allelic Composition |
Myo5ad/Myo5ad-89H
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Genetic Background |
involves: 101/H * C3H/HeH |
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myo5ad mutation
(105 available);
any
Myo5a mutation
(265 available)
Myo5ad-89H mutation
(0 available);
any
Myo5a mutation
(265 available)
|
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integument
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• mice resemble Myo5ad homozygotes
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pigmentation
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• mice resemble Myo5ad homozygotes
|
Allelic Composition |
Myo5ad/Myo5ad-50H
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Genetic Background |
involves: 101/H * C3H/HeH |
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myo5ad mutation
(105 available);
any
Myo5a mutation
(265 available)
Myo5ad-50H mutation
(0 available);
any
Myo5a mutation
(265 available)
|
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|
integument
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• resembles Myo5ad homozygotes
|
pigmentation
|
• resembles Myo5ad homozygotes
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myo5ad mutation
(105 available);
any
Myo5a mutation
(265 available)
Myo5ad-83H mutation
(0 available);
any
Myo5a mutation
(265 available)
|
|
|
integument
|
• resembles Myo5ad homozygotes
|
pigmentation
|
• resembles Myo5ad homozygotes
|
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myo5ad mutation
(105 available);
any
Myo5a mutation
(265 available)
Myo5ad-15H mutation
(0 available);
any
Myo5a mutation
(265 available)
|
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pigmentation
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• the heterozygote shows the same slight dilution as mice homozygous for Myo5ad-15H
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behavior/neurological
N |
• mice with this heterozygous genotype show no abnormal behavior
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integument
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• the heterozygote shows the same slight dilution as mice homozygous for Myo5ad-15H
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Allelic Composition |
d-58H/Myo5ad
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Genetic Background |
involves: 101/H * C3H/HeH |
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
d-58H mutation
(0 available);
any
d-58H mutation
(0 available)
Myo5ad mutation
(105 available);
any
Myo5a mutation
(265 available)
|
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integument
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• resembles Myo5ad homozygotes
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pigmentation
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• resembles Myo5ad homozygotes
|
Allelic Composition |
d-100H/Myo5ad
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Genetic Background |
involves: C3H/HeH |
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
d-100H mutation
(0 available);
any
d-100H mutation
(0 available)
Myo5ad mutation
(105 available);
any
Myo5a mutation
(265 available)
|
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vision/eye
pigmentation
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• paler coat color in both juveniles and adults
• ear pinna lack pigment at 3-4 days of age
• extremities light in color
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integument
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• paler coat color in both juveniles and adults
• ear pinna lack pigment at 3-4 days of age
• extremities light in color
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Allelic Composition |
Myo5ad/Myo5a+ Rgsc80/Rgsc80+
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Genetic Background |
involves: C57BL/6JJcl * DBA/2JJcl |
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pigmentation
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• on the same coat-color background, mice heterozygous for both of these coat color dilution alleles are lighter than mice homozygous wild-type for both and darker than homozygous Myo5ad animals
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integument
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• on the same coat-color background, mice heterozygous for both of these coat color dilution alleles are lighter than mice homozygous wild-type for both and darker than homozygous Myo5ad animals
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pigmentation
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• coat color is pastel gray or silver
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vision/eye
integument
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• coat color is pastel gray or silver
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pigmentation
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• dark sepia in color
• unlike mice wildtype for pink-eye the hairs are pigmented from tip to base and do not have large clumps of pigment, but may have small clumps of pigment
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integument
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• dark sepia in color
• unlike mice wildtype for pink-eye the hairs are pigmented from tip to base and do not have large clumps of pigment, but may have small clumps of pigment
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lystbg-slt mutation
(0 available);
any
Lyst mutation
(225 available)
Myo5ad mutation
(105 available);
any
Myo5a mutation
(265 available)
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pigmentation
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• coat appeared silvery blue
• melanin pigments were nearly absent from the distal third of the hair shaft, but populate the more proximal regions as heavily as in homozygous slate mice
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vision/eye
N |
• eye color was black, except animals that were piebald had reddish eyes
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integument
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• coat appeared silvery blue
• melanin pigments were nearly absent from the distal third of the hair shaft, but populate the more proximal regions as heavily as in homozygous slate mice
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pigmentation
integument
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• random thinning of the coat appeared during the third week of age
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• coat thinning at three weeks of age was followed by a short lag in the second hair growth cycle
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Allelic Composition |
a/a Myo5ad/Myo5ad
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Genetic Background |
involves: DBA/2J |
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pigmentation
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• mice have clumped granules in the hair and skin
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• granules tend to clump in the choroid but not in the retina
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vision/eye
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• granules tend to clump in the choroid but not in the retina
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integument
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• mice have clumped granules in the hair and skin
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nervous system
N |
• mice display none of the neurological defects observed in Myo5ad mice
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pigmentation
N |
• mice display a normal coat color unlike the diluted coat color normally observed in Myo5ad mice
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• the number of melanocytes is increased compared to in Myo5ad mice but is still lower than in wild-type mice
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integument
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• clumping of melanin pigment into large granular clumps in medullary cells reduces the amount of light absorbed producing a blue-gray cast to the coat color
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• clumping of pigment creates local increase in hair diameter
• there are occasional large masses in air spaces between the medullary discs
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• pigment clumps within medullary cells
• shape, size, color, amount and color of melanin are normal
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pigmentation
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• clumping of melanin pigment into large granular clumps in medullary cells reduces the amount of light absorbed producing a blue-gray cast to the coat color
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• reduction in cortical pigment dulls the eye color compared with wild-type
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• fewer and thinner dendritic processes compared with wild-type mice
• melanin granules concentrated in the center of cells
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• pigment clumps within medullary cells
• shape, size, color, amount and color of melanin are normal
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vision/eye
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• reduction in cortical pigment dulls the eye color compared with wild-type
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pigmentation
N |
• mice display a normal coat color unlike the diluted coat color normally observed in Myo5ad mice
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