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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Myo5ad
dilute
MGI:1856004
Summary 29 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Myo5ad/Myo5ad involves: C57BL/6J MGI:5440918
ht2
Myo5ad/Myo5ad-84H involves: 101/H MGI:5300762
ht3
Myo5ad/Myo5ad-51H involves: 101/H * C3H/HeH MGI:5300755
ht4
Myo5ad/Myo5ad-52H involves: 101/H * C3H/HeH MGI:5300756
ht5
Myo5ad/Myo5ad-53H involves: 101/H * C3H/HeH MGI:5300757
ht6
Myo5ad/Myo5ad-78H involves: 101/H * C3H/HeH MGI:5300758
ht7
Myo5ad/Myo5ad-80H involves: 101/H * C3H/HeH MGI:5300759
ht8
Myo5ad/Myo5ad-82H involves: 101/H * C3H/HeH MGI:5300760
ht9
Myo5ad/Myo5ad-86H involves: 101/H * C3H/HeH MGI:5300763
ht10
Myo5ad/Myo5ad-97H involves: 101/H * C3H/HeH MGI:5300764
ht11
Myo5ad/Myo5ad-93H involves: 101/H * C3H/HeH MGI:5301942
ht12
Myo5ad/Myo5ad-105H involves: 101/H * C3H/HeH MGI:5301943
ht13
Myo5ad/Myo5ad-85H involves: 101/H * C3H/HeH MGI:5313312
ht14
Myo5ad/Myo5ad-89H involves: 101/H * C3H/HeH MGI:5313314
ht15
Myo5ad/Myo5ad-50H involves: 101/H * C3H/HeH MGI:5300754
ht16
Myo5ad/Myo5ad-83H involves: C3H/HeH MGI:5300761
ht17
Myo5ad/Myo5ad-15H Not Specified MGI:4410295
cx18
d-58H/Myo5ad involves: 101/H * C3H/HeH MGI:5301094
cx19
d-100H/Myo5ad involves: C3H/HeH MGI:5301096
cx20
Hps3coa/Hps3coa
Myo5ad/Myo5ad
Mregdsu/Mregdsu
involves: C57BL/10J MGI:3587103
cx21
Myo5ad/Myo5a+
Rgsc80/Rgsc80+
involves: C57BL/6JJcl * DBA/2JJcl MGI:3798690
cx22
MitfMi-wh/Mitf+
Myo5ad/Myo5ad
involves: C57BL * DBA MGI:3762341
cx23
a/a
Myo5ad/Myo5a+
Oca2p/Oca2+
Tyrp1B-lt/Tyrp1+
involves: C58 * CT/Ch MGI:3795191
cx24
Lystbg-slt/Lystbg-slt
Myo5ad/Myo5ad
involves: CT/Ch * YZ57/Ch MGI:2661034
cx25
Lystbg-slt/Lystbg-slt
Myo5ad/Myo5ad
Oca2p/Oca2p
Tyrp1b/Tyrp1b
involves: CT/Ch * YZ57/Ch MGI:2661267
cx26
a/a
Myo5ad/Myo5ad
involves: DBA/2J MGI:4454433
cx27
Mregdsu/Mregdsu
Myo5ad/Myo5ad
involves: DBA/2J MGI:3768122
cx28
a/a
Myo5ad/Myo5ad
Not Specified MGI:5440857
cx29
Mregdsu/Mregdsu
Myo5ad/Myo5ad
STOCK a Myo5ad Hephl1cw MGI:3768123


Genotype
MGI:5440918
hm1
Allelic
Composition
Myo5ad/Myo5ad
Genetic
Background
involves: C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myo5ad mutation (105 available); any Myo5a mutation (231 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
pigmentation
• cultured primary melanocytes display clustering of melanosomes but are otherwise normal




Genotype
MGI:5300762
ht2
Allelic
Composition
Myo5ad/Myo5ad-84H
Genetic
Background
involves: 101/H
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myo5ad mutation (105 available); any Myo5a mutation (231 available)
Myo5ad-84H mutation (0 available); any Myo5a mutation (231 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
integument
• resembles Myo5ad homozygotes

pigmentation
• resembles Myo5ad homozygotes




Genotype
MGI:5300755
ht3
Allelic
Composition
Myo5ad/Myo5ad-51H
Genetic
Background
involves: 101/H * C3H/HeH
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myo5ad mutation (105 available); any Myo5a mutation (231 available)
Myo5ad-51H mutation (0 available); any Myo5a mutation (231 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
integument
• resembles Myo5ad homozygotes

pigmentation
• resembles Myo5ad homozygotes




Genotype
MGI:5300756
ht4
Allelic
Composition
Myo5ad/Myo5ad-52H
Genetic
Background
involves: 101/H * C3H/HeH
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myo5ad mutation (105 available); any Myo5a mutation (231 available)
Myo5ad-52H mutation (0 available); any Myo5a mutation (231 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
integument
• resembles Myo5ad homozygotes

pigmentation
• resembles Myo5ad homozygotes




Genotype
MGI:5300757
ht5
Allelic
Composition
Myo5ad/Myo5ad-53H
Genetic
Background
involves: 101/H * C3H/HeH
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myo5ad mutation (105 available); any Myo5a mutation (231 available)
Myo5ad-53H mutation (0 available); any Myo5a mutation (231 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
integument
• resembles Myo5ad homozygotes

pigmentation
• resembles Myo5ad homozygotes




Genotype
MGI:5300758
ht6
Allelic
Composition
Myo5ad/Myo5ad-78H
Genetic
Background
involves: 101/H * C3H/HeH
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myo5ad mutation (105 available); any Myo5a mutation (231 available)
Myo5ad-78H mutation (0 available); any Myo5a mutation (231 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
integument
• resembles Myo5ad homozygotes

pigmentation
• resembles Myo5ad homozygotes




Genotype
MGI:5300759
ht7
Allelic
Composition
Myo5ad/Myo5ad-80H
Genetic
Background
involves: 101/H * C3H/HeH
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myo5ad mutation (105 available); any Myo5a mutation (231 available)
Myo5ad-80H mutation (0 available); any Myo5a mutation (231 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
integument
• resembles Myo5ad homozygotes

pigmentation
• resembles Myo5ad homozygotes




Genotype
MGI:5300760
ht8
Allelic
Composition
Myo5ad/Myo5ad-82H
Genetic
Background
involves: 101/H * C3H/HeH
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myo5ad mutation (105 available); any Myo5a mutation (231 available)
Myo5ad-82H mutation (0 available); any Myo5a mutation (231 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
integument
• resembles Myo5ad homozygotes

pigmentation
• resembles Myo5ad homozygotes




Genotype
MGI:5300763
ht9
Allelic
Composition
Myo5ad/Myo5ad-86H
Genetic
Background
involves: 101/H * C3H/HeH
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myo5ad mutation (105 available); any Myo5a mutation (231 available)
Myo5ad-86H mutation (0 available); any Myo5a mutation (231 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
integument
• resembles Myo5ad homozygotes

pigmentation
• resembles Myo5ad homozygotes




Genotype
MGI:5300764
ht10
Allelic
Composition
Myo5ad/Myo5ad-97H
Genetic
Background
involves: 101/H * C3H/HeH
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myo5ad mutation (105 available); any Myo5a mutation (231 available)
Myo5ad-97H mutation (0 available); any Myo5a mutation (231 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
normal phenotype
• mice are viable




Genotype
MGI:5301942
ht11
Allelic
Composition
Myo5ad/Myo5ad-93H
Genetic
Background
involves: 101/H * C3H/HeH
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myo5ad mutation (105 available); any Myo5a mutation (231 available)
Myo5ad-93H mutation (0 available); any Myo5a mutation (231 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
integument
• resembles Myo5ad homozygotes

pigmentation
• resembles Myo5ad homozygotes




Genotype
MGI:5301943
ht12
Allelic
Composition
Myo5ad/Myo5ad-105H
Genetic
Background
involves: 101/H * C3H/HeH
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myo5ad mutation (105 available); any Myo5a mutation (231 available)
Myo5ad-105H mutation (0 available); any Myo5a mutation (231 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
normal phenotype
• mice are viable




Genotype
MGI:5313312
ht13
Allelic
Composition
Myo5ad/Myo5ad-85H
Genetic
Background
involves: 101/H * C3H/HeH
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myo5ad mutation (105 available); any Myo5a mutation (231 available)
Myo5ad-85H mutation (0 available); any Myo5a mutation (231 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
integument
• mice resemble Myo5ad homozygotes

pigmentation
• mice resemble Myo5ad homozygotes




Genotype
MGI:5313314
ht14
Allelic
Composition
Myo5ad/Myo5ad-89H
Genetic
Background
involves: 101/H * C3H/HeH
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myo5ad mutation (105 available); any Myo5a mutation (231 available)
Myo5ad-89H mutation (0 available); any Myo5a mutation (231 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
integument
• mice resemble Myo5ad homozygotes

pigmentation
• mice resemble Myo5ad homozygotes




Genotype
MGI:5300754
ht15
Allelic
Composition
Myo5ad/Myo5ad-50H
Genetic
Background
involves: 101/H * C3H/HeH
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myo5ad mutation (105 available); any Myo5a mutation (231 available)
Myo5ad-50H mutation (0 available); any Myo5a mutation (231 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
integument
• resembles Myo5ad homozygotes

pigmentation
• resembles Myo5ad homozygotes




Genotype
MGI:5300761
ht16
Allelic
Composition
Myo5ad/Myo5ad-83H
Genetic
Background
involves: C3H/HeH
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myo5ad mutation (105 available); any Myo5a mutation (231 available)
Myo5ad-83H mutation (0 available); any Myo5a mutation (231 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
integument
• resembles Myo5ad homozygotes

pigmentation
• resembles Myo5ad homozygotes




Genotype
MGI:4410295
ht17
Allelic
Composition
Myo5ad/Myo5ad-15H
Genetic
Background
Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myo5ad mutation (105 available); any Myo5a mutation (231 available)
Myo5ad-15H mutation (0 available); any Myo5a mutation (231 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
pigmentation
• the heterozygote shows the same slight dilution as mice homozygous for Myo5ad-15H

behavior/neurological
N
• mice with this heterozygous genotype show no abnormal behavior

integument
• the heterozygote shows the same slight dilution as mice homozygous for Myo5ad-15H




Genotype
MGI:5301094
cx18
Allelic
Composition
d-58H/Myo5ad
Genetic
Background
involves: 101/H * C3H/HeH
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
d-58H mutation (0 available); any d-58H mutation (0 available)
Myo5ad mutation (105 available); any Myo5a mutation (231 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
integument
• resembles Myo5ad homozygotes

pigmentation
• resembles Myo5ad homozygotes




Genotype
MGI:5301096
cx19
Allelic
Composition
d-100H/Myo5ad
Genetic
Background
involves: C3H/HeH
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
d-100H mutation (0 available); any d-100H mutation (0 available)
Myo5ad mutation (105 available); any Myo5a mutation (231 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
normal phenotype
• mice are viable




Genotype
MGI:3587103
cx20
Allelic
Composition
Hps3coa/Hps3coa
Myo5ad/Myo5ad
Mregdsu/Mregdsu
Genetic
Background
involves: C57BL/10J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hps3coa mutation (1 available); any Hps3 mutation (36 available)
Mregdsu mutation (1 available); any Mreg mutation (101 available)
Myo5ad mutation (105 available); any Myo5a mutation (231 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
vision/eye
• lack eye pigment

pigmentation
• paler coat color in both juveniles and adults
• ear pinna lack pigment at 3-4 days of age
• extremities light in color
• lack eye pigment

integument
• paler coat color in both juveniles and adults
• ear pinna lack pigment at 3-4 days of age
• extremities light in color

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
Hermansky-Pudlak syndrome 3 DOID:0060541 OMIM:614072
J:29467




Genotype
MGI:3798690
cx21
Allelic
Composition
Myo5ad/Myo5a+
Rgsc80/Rgsc80+
Genetic
Background
involves: C57BL/6JJcl * DBA/2JJcl
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myo5ad mutation (105 available); any Myo5a mutation (231 available)
Rgsc80 mutation (1 available); any Rgsc80 mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
pigmentation
• on the same coat-color background, mice heterozygous for both of these coat color dilution alleles are lighter than mice homozygous wild-type for both and darker than homozygous Myo5ad animals

integument
• on the same coat-color background, mice heterozygous for both of these coat color dilution alleles are lighter than mice homozygous wild-type for both and darker than homozygous Myo5ad animals




Genotype
MGI:3762341
cx22
Allelic
Composition
MitfMi-wh/Mitf+
Myo5ad/Myo5ad
Genetic
Background
involves: C57BL * DBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
MitfMi-wh mutation (8 available); any Mitf mutation (66 available)
Myo5ad mutation (105 available); any Myo5a mutation (231 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
pigmentation
• coat color is pastel gray or silver
• eyes are red

vision/eye
• eyes are red

integument
• coat color is pastel gray or silver




Genotype
MGI:3795191
cx23
Allelic
Composition
a/a
Myo5ad/Myo5a+
Oca2p/Oca2+
Tyrp1B-lt/Tyrp1+
Genetic
Background
involves: C58 * CT/Ch
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
a mutation (229 available); any a mutation (460 available)
Myo5ad mutation (105 available); any Myo5a mutation (231 available)
Oca2p mutation (11 available); any Oca2 mutation (58 available)
Tyrp1B-lt mutation (4 available); any Tyrp1 mutation (144 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
pigmentation
• dark sepia in color
• unlike mice wildtype for pink-eye the hairs are pigmented from tip to base and do not have large clumps of pigment, but may have small clumps of pigment

integument
• dark sepia in color
• unlike mice wildtype for pink-eye the hairs are pigmented from tip to base and do not have large clumps of pigment, but may have small clumps of pigment




Genotype
MGI:2661034
cx24
Allelic
Composition
Lystbg-slt/Lystbg-slt
Myo5ad/Myo5ad
Genetic
Background
involves: CT/Ch * YZ57/Ch
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lystbg-slt mutation (0 available); any Lyst mutation (154 available)
Myo5ad mutation (105 available); any Myo5a mutation (231 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
pigmentation
• coat appeared silvery blue
• melanin pigments were nearly absent from the distal third of the hair shaft, but populate the more proximal regions as heavily as in homozygous slate mice

vision/eye
N
• eye color was black, except animals that were piebald had reddish eyes

integument
• coat appeared silvery blue
• melanin pigments were nearly absent from the distal third of the hair shaft, but populate the more proximal regions as heavily as in homozygous slate mice




Genotype
MGI:2661267
cx25
Allelic
Composition
Lystbg-slt/Lystbg-slt
Myo5ad/Myo5ad
Oca2p/Oca2p
Tyrp1b/Tyrp1b
Genetic
Background
involves: CT/Ch * YZ57/Ch
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lystbg-slt mutation (0 available); any Lyst mutation (154 available)
Myo5ad mutation (105 available); any Myo5a mutation (231 available)
Oca2p mutation (11 available); any Oca2 mutation (58 available)
Tyrp1b mutation (29 available); any Tyrp1 mutation (144 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
pigmentation

integument
• random thinning of the coat appeared during the third week of age
• coat thinning at three weeks of age was followed by a short lag in the second hair growth cycle




Genotype
MGI:4454433
cx26
Allelic
Composition
a/a
Myo5ad/Myo5ad
Genetic
Background
involves: DBA/2J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
a mutation (229 available); any a mutation (460 available)
Myo5ad mutation (105 available); any Myo5a mutation (231 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
pigmentation
• mice have clumped granules in the hair and skin
• granules tend to clump in the choroid but not in the retina

vision/eye
• granules tend to clump in the choroid but not in the retina

integument
• mice have clumped granules in the hair and skin




Genotype
MGI:3768122
cx27
Allelic
Composition
Mregdsu/Mregdsu
Myo5ad/Myo5ad
Genetic
Background
involves: DBA/2J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mregdsu mutation (1 available); any Mreg mutation (101 available)
Myo5ad mutation (105 available); any Myo5a mutation (231 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
N
• mice display none of the neurological defects observed in Myo5ad mice

pigmentation
N
• mice display a normal coat color unlike the diluted coat color normally observed in Myo5ad mice
• the number of melanocytes is increased compared to in Myo5ad mice but is still lower than in wild-type mice




Genotype
MGI:5440857
cx28
Allelic
Composition
a/a
Myo5ad/Myo5ad
Genetic
Background
Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
a mutation (229 available); any a mutation (460 available)
Myo5ad mutation (105 available); any Myo5a mutation (231 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
integument
• clumping of melanin pigment into large granular clumps in medullary cells reduces the amount of light absorbed producing a blue-gray cast to the coat color
• clumping of pigment creates local increase in hair diameter
• there are occasional large masses in air spaces between the medullary discs
• pigment clumps within medullary cells
• shape, size, color, amount and color of melanin are normal

pigmentation
• clumping of melanin pigment into large granular clumps in medullary cells reduces the amount of light absorbed producing a blue-gray cast to the coat color
• reduction in cortical pigment dulls the eye color compared with wild-type
• fewer and thinner dendritic processes compared with wild-type mice
• melanin granules concentrated in the center of cells
• pigment clumps within medullary cells
• shape, size, color, amount and color of melanin are normal

vision/eye
• reduction in cortical pigment dulls the eye color compared with wild-type




Genotype
MGI:3768123
cx29
Allelic
Composition
Mregdsu/Mregdsu
Myo5ad/Myo5ad
Genetic
Background
STOCK a Myo5ad Hephl1cw
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mregdsu mutation (1 available); any Mreg mutation (101 available)
Myo5ad mutation (105 available); any Myo5a mutation (231 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
pigmentation
N
• mice display a normal coat color unlike the diluted coat color normally observed in Myo5ad mice





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last database update
08/03/2022
MGI 6.21
The Jackson Laboratory