Analysis Tools
immune system
|
• Background Sensitivity: mice are less susceptible to experimental cryptococcosis infection than mice homozygous for the Lystbg-J allele on C57BL/6
|
neoplasm
|
• mutant mice had a significantly higher retention of the introduced tumor variant, CIRAS 1, than normal mice after an exercise regime or sedentary
activity
• mutant mice randomly assigned 9 week treadmill training had lower CIRAS 1 tumor cell retention (44 +/- 3%) than mice displaying sedentary behavior (53 +/- 3%); there was no difference seen for the more aggressive tumor variant CIRAS 3
|
behavior/neurological
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• obvious by 17 months of age
|
|
• mice lose ability to swim by 17 months of age
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abnormal gait
(
J:15166
)
|
• an impaired gait is obvious by 17 months of age
|
paraparesis
(
J:15166
)
|
• motor weakness of the hind legs is noticeable by 17 months of age
|
nervous system
|
• there is a complete or nearly complete loss of cells in mice showing neurological symptoms by 17 months of age
• mice in their second year of life and without obvious abnormal neurological behavior have a significant reduction in number of cells
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