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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Lystbg-2J
beige 2 Jackson
MGI:1855970
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Lystbg-2J/Lystbg-2J C3.Cg-Lystbg-2J/J MGI:3848125
hm2
Lystbg-2J/Lystbg-2J Not Specified MGI:3848056


Genotype
MGI:3848125
hm1
Allelic
Composition
Lystbg-2J/Lystbg-2J
Genetic
Background
C3.Cg-Lystbg-2J/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lystbg-2J mutation (2 available); any Lyst mutation (153 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• Background Sensitivity: mice are less susceptible to experimental cryptococcosis infection than mice homozygous for the Lystbg-J allele on C57BL/6

neoplasm
• mutant mice had a significantly higher retention of the introduced tumor variant, CIRAS 1, than normal mice after an exercise regime or sedentary activity
• mutant mice randomly assigned 9 week treadmill training had lower CIRAS 1 tumor cell retention (44 +/- 3%) than mice displaying sedentary behavior (53 +/- 3%); there was no difference seen for the more aggressive tumor variant CIRAS 3

behavior/neurological
• a fine sustained tremor is observed by 17 months of age
• obvious by 17 months of age
• mice lose ability to swim by 17 months of age
• an impaired gait is obvious by 17 months of age
• motor weakness of the hind legs is noticeable by 17 months of age

nervous system
• there is a complete or nearly complete loss of cells in mice showing neurological symptoms by 17 months of age
• mice in their second year of life and without obvious abnormal neurological behavior have a significant reduction in number of cells




Genotype
MGI:3848056
hm2
Allelic
Composition
Lystbg-2J/Lystbg-2J
Genetic
Background
Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lystbg-2J mutation (2 available); any Lyst mutation (153 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
pigmentation
• pigmentation is reduced
• coat color is lighter than that of normal wild-type mice of the same background
• pigmentation is reduced
• eye color is light at birth, varying from ruby to almost black in adults

craniofacial
• pigmentation is reduced

hearing/vestibular/ear
• pigmentation is reduced

limbs/digits/tail
• pigmentation is reduced

vision/eye
• eye color is light at birth, varying from ruby to almost black in adults

integument
• pigmentation is reduced
• coat color is lighter than that of normal wild-type mice of the same background
• pigmentation is reduced

growth/size/body
• pigmentation is reduced





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
01/12/2022
MGI 6.17
The Jackson Laboratory