Mouse Genome Informatics
hm1
    Tyrp1B-lt/Tyrp1B-lt
C58
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
pigmentation
• hair tips are brown, the rest of the hair shaft white
• mice are distinguished from normal by 2 weeks of age
• coat color is rapidly lightened as hair lengthens
• moulting often creates a mosaic coat color pattern
• the lighter coat color is difficult to see on an agouti background

integument
• hair tips are brown, the rest of the hair shaft white
• mice are distinguished from normal by 2 weeks of age
• coat color is rapidly lightened as hair lengthens
• moulting often creates a mosaic coat color pattern
• the lighter coat color is difficult to see on an agouti background


Mouse Genome Informatics
hm2
    Tyrp1B-lt/Tyrp1B-lt
involves: C57BL/6J
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
homeostasis/metabolism
• bleed time of 5.7 minutes on average after tail nick is higher than the 3.8 minutes in C57BL/6J controls


Mouse Genome Informatics
hm3
    Tyrp1B-lt/Tyrp1B-lt
LT/SvEiJ
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype

Tyrp1B-lt/Tyrp1B-lt

pigmentation
• iris pigmentation is dispersed

vision/eye
• iris pigmentation is dispersed


Mouse Genome Informatics
hm4
    Tyrp1B-lt/Tyrp1B-lt
Not Specified
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
hearing/vestibular/ear
• pigmentation is abundant as clumps in older mice
• loss of endocochlear potential correlates with loss of pigment
• potential is reduced to 19-59mV in 30% of two age groups: 2.5 to 4 mo and 1-2 years
• loss of potential is correlated with loss of pigment with age

pigmentation
• pigmentation is abundant as clumps in older mice
• pigment is lost as mice age
• base of hairs become lighter as more pigment is lost with age, older mice are pale grey in color
• pigment loss is due to premature melanocyte death mediated by natural toxicity of pigment production

integument
• pigment is lost as mice age
• base of hairs become lighter as more pigment is lost with age, older mice are pale grey in color
• pigment loss is due to premature melanocyte death mediated by natural toxicity of pigment production


Mouse Genome Informatics
ht5
    Tyrp1B-lt/Tyrp1+
C58
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
pigmentation
• the majority of each hair from tip down is pigmented, the lower part is less pigmented appearing gray
• mice are lighter than wildtype nonagouti mice but darker than homozygotes

integument
• the majority of each hair from tip down is pigmented, the lower part is less pigmented appearing gray
• mice are lighter than wildtype nonagouti mice but darker than homozygotes


Mouse Genome Informatics
ht6
    Tyrp1B-lt/Tyrp1+
Not Specified
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
hearing/vestibular/ear
• potential is reduced in 30% of mice as mice age
• reduction in potential is correlated with appearance of abundant pigment clumps in the stria vascularis

pigmentation
• coat pigment is reduced with age

integument
• coat pigment is reduced with age


Mouse Genome Informatics
cx7
    a/a
Myo5ad/Myo5a+
Oca2p/Oca2+
Tyrp1B-lt/Tyrp1+

involves: C58 * CT/Ch
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
pigmentation
• dark sepia in color
• unlike mice wildtype for pink-eye the hairs are pigmented from tip to base and do not have large clumps of pigment, but may have small clumps of pigment

integument
• dark sepia in color
• unlike mice wildtype for pink-eye the hairs are pigmented from tip to base and do not have large clumps of pigment, but may have small clumps of pigment


Mouse Genome Informatics
cx8
    a/a
Tyrp1B-lt/Tyrp1B-lt

Not Specified
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
pigmentation
• the ventral hairs are substantially less pigmented than those of the dorsum
• although in early stages of hair growth the granules are round and relatively uniform in size, in later stages they are larger, more variable in size, and some clumping is found
• by the 9th day of a new hair growth cycle some hair bulbs are devoid of pigmentation and by 14 days very few follicles have active melanocytes
• variation in the amount of pigmentation present in one hair shaft versus the next
• variation in the size ans shape of pigment granules, with some instances of large masses of pigment in a particular hair shaft
• hair shafts have large clumps of pigmented granules predominantly restricted to the medullary regions
• decreased pigmentation in the hair shafts with age

integument
• the ventral hairs are substantially less pigmented than those of the dorsum
• although in early stages of hair growth the granules are round and relatively uniform in size, in later stages they are larger, more variable in size, and some clumping is found
• by the 9th day of a new hair growth cycle some hair bulbs are devoid of pigmentation and by 14 days very few follicles have active melanocytes
• variation in the amount of pigmentation present in one hair shaft versus the next
• variation in the size ans shape of pigment granules, with some instances of large masses of pigment in a particular hair shaft
• hair shafts have large clumps of pigmented granules predominantly restricted to the medullary regions
• decreased pigmentation in the hair shafts with age


Mouse Genome Informatics
cx9
    a/a
Tyrp1B-lt/Tyrp1+

Not Specified
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
pigmentation
• the ventral hairs are substantially less pigmented than those of the dorsum
• large clumps of pigment are found in hair and vibrissae, but less frequently than in homozygotes
• fewer pigment granules per septum in proceeding from tip to base of the hair, but more pigment granules than in homozygotes

integument
• the ventral hairs are substantially less pigmented than those of the dorsum
• large clumps of pigment are found in hair and vibrissae, but less frequently than in homozygotes
• fewer pigment granules per septum in proceeding from tip to base of the hair, but more pigment granules than in homozygotes


Mouse Genome Informatics
cx10
    A/a
Tyrp1B-lt/Tyrp1B-lt

Not Specified
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
pigmentation
• more dilute than mice heterozygous for light due to a further diminution in the eumelanic pigment, but there is no alteration in the yellow bands of the hair shaft

integument
• more dilute than mice heterozygous for light due to a further diminution in the eumelanic pigment, but there is no alteration in the yellow bands of the hair shaft


Mouse Genome Informatics
cx11
    Ay/a
Tyrp1B-lt/?

Not Specified
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
pigmentation
• the light mutation does not seem to impact the yellow phenotype since the coat color of mice without the light mutation is the same yellow coat color as that found in mice carrying at least one copy of the light mutation

integument
• the light mutation does not seem to impact the yellow phenotype since the coat color of mice without the light mutation is the same yellow coat color as that found in mice carrying at least one copy of the light mutation