All Phenotypes Tyrp1<b> MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Tyrp1^b
brown
MGI:1855960

Summary

56 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tyrp1^b/Tyrp1^b	B6.D2-Tyrp1^b	MGI:3773275
ht2	Tyrp1^b/Tyrp1^b-65H	involves: 101/H * C3H/HeH	MGI:5308108
ht3	Tyrp1^b-cH/Tyrp1^b	involves: 101/H * C3H/HeH * T Stock	MGI:3795458
ht4	Tyrp1^b/Tyrp1^b-13DT	involves: 101/Rl * C3H/Rl	MGI:3719228
ht5	Tyrp1^b/Tyrp1^b-13R75M	involves: 101/Rl * C3H/Rl	MGI:3719231
ht6	Tyrp1^b/Tyrp1^b-173G	involves: 101/Rl * C3H/Rl	MGI:3719233
ht7	Tyrp1^b/Tyrp1^b-1DFiOD	involves: 101/Rl * C3H/Rl	MGI:3719240
ht8	Tyrp1^b/Tyrp1^b-1ETOPc	involves: 101/Rl * C3H/Rl	MGI:3719244
ht9	Tyrp1^b/Tyrp1^b-1FBleo	involves: 101/Rl * C3H/Rl	MGI:3719249
ht10	Tyrp1^b/Tyrp1^b-1FCHLc	involves: 101/Rl * C3H/Rl	MGI:3719252
ht11	Tyrp1^b/Tyrp1^b-1MLP5	involves: 101/Rl * C3H/Rl	MGI:3719256
ht12	Tyrp1^b/Tyrp1^b-1OZ	involves: 101/Rl * C3H/Rl	MGI:3719259
ht13	Tyrp1^b/Tyrp1^b-1THO-IV	involves: 101/Rl * C3H/Rl	MGI:3719262
ht14	Tyrp1^b/Tyrp1^b-11PU	involves: 101/Rl * C3H/Rl	MGI:3719218
ht15	Tyrp1^b/Tyrp1^b-2MLP10	involves: 101/Rl * C3H/Rl	MGI:3719267
ht16	Tyrp1^b/Tyrp1^b-2MLP7.5	involves: 101/Rl * C3H/Rl	MGI:3719270
ht17	Tyrp1^b/Tyrp1^b-331K	involves: 101/Rl * C3H/Rl	MGI:3719275
ht18	Tyrp1^b/Tyrp1^b-33G	involves: 101/Rl * C3H/Rl	MGI:3719277
ht19	Tyrp1^b/Tyrp1^b-37DTD	involves: 101/Rl * C3H/Rl	MGI:3719278
ht20	Tyrp1^b/Tyrp1^b-37FrThc	involves: 101/Rl * C3H/Rl	MGI:3719281
ht21	Tyrp1^b/Tyrp1^b-37Pub	involves: 101/Rl * C3H/Rl	MGI:3719282
ht22	Tyrp1^b/Tyrp1^b-3CHLe	involves: 101/Rl * C3H/Rl	MGI:3719285
ht23	Tyrp1^b/Tyrp1^b-3MLPc	involves: 101/Rl * C3H/Rl	MGI:3719356
ht24	Tyrp1^b/Tyrp1^b-3YPSc	involves: 101/Rl * C3H/Rl	MGI:3719358
ht25	Tyrp1^b/Tyrp1^b-3YPSh	involves: 101/Rl * C3H/Rl	MGI:3719360
ht26	Tyrp1^b/Tyrp1^b-46UThc	involves: 101/Rl * C3H/Rl	MGI:3719362
ht27	Tyrp1^b/Tyrp1^b-47DThWb	involves: 101/Rl * C3H/Rl	MGI:3719364
ht28	Tyrp1^b/Tyrp1^b-49HATh	involves: 101/Rl * C3H/Rl	MGI:3719366
ht29	Tyrp1^b/Tyrp1^b-4ACRg	involves: 101/Rl * C3H/Rl	MGI:3719368
ht30	Tyrp1^b/Tyrp1^b-51DThWb	involves: 101/Rl * C3H/Rl	MGI:3719370
ht31	Tyrp1^b/Tyrp1^b-55CoS	involves: 101/Rl * C3H/Rl	MGI:3719372
ht32	Tyrp1^b/Tyrp1^b-5CHLe	involves: 101/Rl * C3H/Rl	MGI:3719374
ht33	Tyrp1^b/Tyrp1^b-5CHLo	involves: 101/Rl * C3H/Rl	MGI:3719376
ht34	Tyrp1^b/Tyrp1^b-5MLPm	involves: 101/Rl * C3H/Rl	MGI:3719378
ht35	Tyrp1^b/Tyrp1^b-5FBleb	involves: 101/Rl * C3H/Rl	MGI:3719380
ht36	Tyrp1^b/Tyrp1^b-8PUb	involves: 101/Rl * C3H/Rl	MGI:3719382
ht37	Tyrp1^b/Tyrp1^b-9Bleo	involves: 101/Rl * C3H/Rl	MGI:3719384
ht38	Tyrp1^b/Tyrp1^b-9PU	involves: 101/Rl * C3H/Rl	MGI:3719386
ht39	Tyrp1^b/Tyrp1^b-9R75VH	involves: 101/Rl * C3H/Rl	MGI:3719388
ht40	Tyrp1^B-w/Tyrp1^b	involves: 101/Rl * C3H/Rl	MGI:3771332
ht41	Tyrp1^b/Tyrp1^b-26R60L	involves: 101/Rl * C3H/Rl	MGI:3719264
ht42	Tyrp1^b/Tyrp1^b-11R30M	involves: 101/Rl * C3H/Rl	MGI:3719219
ht43	Tyrp1^b/Tyrp1^b-12PU	involves: 101/Rl * C3H/Rl	MGI:3719224
ht44	Tyrp1^b/Tyrp1^b-55H	involves: C3H/HeH	MGI:5308106
ht45	Tyrp1^b/Tyrp1^rgsc671	involves: C57BL/6JJcl * DBA/2JJcl	MGI:3806985
cx46	Gpnmb^R150X/Gpnmb^R150X Tyr^c-2J/Tyr^c-2J Tyrp1^b/Tyrp1^b	B6.Cg-Tyrp1^b Gpnmb^R150X Tyr^c-2J	MGI:3773287
cx47	Gpnmb^R150X/Gpnmb^R150X Tyrp1^b/Tyrp1^b	B6.D2-Tyrp1^b Gpnmb^R150X	MGI:3773276
cx48	a/a Mlph^ln/Mlph^ln Tyrp1^b/Tyrp1^b	C57L/J	MGI:3052536
cx49	a/a Lyst^bg/Lyst^bg Tyrp1^b/Tyrp1^b	involves: C3H/Rl * C57BL/6J	MGI:4454432
cx50	a/a Tyrp1^b/Tyrp1^b	involves: C57BL/6J	MGI:4454425
cx51	Rgsc58/Rgsc58⁺ Tyrp1^b/Tyrp1^b	involves: C57BL/6JJcl * DBA/2JJcl	MGI:3798628
cx52	Lyst^bg-slt/Lyst^bg-slt Myo5a^d/Myo5a^d Oca2^p/Oca2^p Tyrp1^b/Tyrp1^b	involves: CT/Ch * YZ57/Ch	MGI:2661267
cx53	A/? Lyst^bg/Lyst^bg Tyrp1^b/Tyrp1^b	Not Specified	MGI:2654822
cx54	a/a Tyrp1^b/Tyrp1^b wad/wad⁺	Not Specified	MGI:4818897
cx55	a/a Tyrp1^b/Tyrp1^b wad/wad	Not Specified	MGI:4818908
cx56	a/a Tyrp1^b/Tyrp1^b	Not Specified	MGI:5440939

Allelic Composition	Tyrp1^b/Tyrp1^b
Genetic Background	B6.D2-Tyrp1^b

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tyrp1^b mutation (29 available); any Tyrp1 mutation (162 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

abnormal iris morphology ( J:128215 )

• mutants develop iris disease that is first noticeable at 6 months of age when a population of small phagocytic clump cells began to be discernible across the iris surface

• with age, the underlying vasculature becomes obscured, and irides appear increasingly coarse and atrophic, particularly at the pupil margin where a narrow white band of underlying tissue is exposed

• with advanced age, full-thickness iris holes occur, but rarely before 2 years of age

iris atrophy ( J:128215 )

• irises are normal at 1-6 months of age, however, after 6 months of age, eyes show a gradual atrophy of the iris stroma

Allelic Composition	Tyrp1^b/Tyrp1^b-65H
Genetic Background	involves: 101/H * C3H/HeH

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tyrp1^b mutation (29 available); any Tyrp1 mutation (162 available)
Tyrp1^b-65H mutation (0 available); any Tyrp1 mutation (162 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

integument

abnormal coat/hair pigmentation ( J:180879 )

• brown fur

craniofacial

domed cranium ( J:180879 )

small ears ( J:180879 )

growth/size/body

small ears ( J:180879 )

decreased body size ( J:180879 )

hearing/vestibular/ear

small ears ( J:180879 )

pigmentation

abnormal coat/hair pigmentation ( J:180879 )

• brown fur

skeleton

domed cranium ( J:180879 )

Allelic Composition	Tyrp1^b-cH/Tyrp1^b
Genetic Background	involves: 101/H * C3H/HeH * T Stock

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tyrp1^b mutation (29 available); any Tyrp1 mutation (162 available)
Tyrp1^b-cH mutation (0 available); any Tyrp1 mutation (162 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

pigmentation

abnormal coat/hair pigmentation ( J:44436 )

• dark brown

integument

abnormal coat/hair pigmentation ( J:44436 )

• dark brown

Allelic Composition	Tyrp1^b/Tyrp1^b-13DT
Genetic Background	involves: 101/Rl * C3H/Rl

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tyrp1^b mutation (29 available); any Tyrp1 mutation (162 available)
Tyrp1^b-13DT mutation (1 available); any Tyrp1 mutation (162 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

pigmentation

abnormal coat/hair pigmentation ( J:100221 )

• hair eumelanin pigment is brown

decreased eye pigmentation ( J:100221 )

vision/eye

decreased eye pigmentation ( J:100221 )

integument

abnormal coat/hair pigmentation ( J:100221 )

• hair eumelanin pigment is brown

Allelic Composition	Tyrp1^b/Tyrp1^b-13R75M
Genetic Background	involves: 101/Rl * C3H/Rl

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tyrp1^b mutation (29 available); any Tyrp1 mutation (162 available)
Tyrp1^b-13R75M mutation (1 available); any Tyrp1 mutation (162 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

pigmentation

abnormal coat/hair pigmentation ( J:100221 )

• hair eumelanin pigment is brown

decreased eye pigmentation ( J:100221 )

vision/eye

decreased eye pigmentation ( J:100221 )

integument

abnormal coat/hair pigmentation ( J:100221 )

• hair eumelanin pigment is brown

Allelic Composition	Tyrp1^b/Tyrp1^b-173G
Genetic Background	involves: 101/Rl * C3H/Rl

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tyrp1^b mutation (29 available); any Tyrp1 mutation (162 available)
Tyrp1^b-173G mutation (1 available); any Tyrp1 mutation (162 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

pigmentation

abnormal coat/hair pigmentation ( J:100221 )

• hair eumelanin pigment is brown

decreased eye pigmentation ( J:100221 )

vision/eye

decreased eye pigmentation ( J:100221 )

integument

abnormal coat/hair pigmentation ( J:100221 )

• hair eumelanin pigment is brown

Allelic Composition	Tyrp1^b/Tyrp1^b-1DFiOD
Genetic Background	involves: 101/Rl * C3H/Rl

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tyrp1^b mutation (29 available); any Tyrp1 mutation (162 available)
Tyrp1^b-1DFiOD mutation (1 available); any Tyrp1 mutation (162 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

pigmentation

abnormal coat/hair pigmentation ( J:100221 )

• hair eumelanin pigment is brown

decreased eye pigmentation ( J:100221 )

vision/eye

decreased eye pigmentation ( J:100221 )

integument

abnormal coat/hair pigmentation ( J:100221 )

• hair eumelanin pigment is brown

Allelic Composition	Tyrp1^b/Tyrp1^b-1ETOPc
Genetic Background	involves: 101/Rl * C3H/Rl

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tyrp1^b mutation (29 available); any Tyrp1 mutation (162 available)
Tyrp1^b-1ETOPc mutation (1 available); any Tyrp1 mutation (162 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

pigmentation

abnormal coat/hair pigmentation ( J:100221 )

• hair eumelanin pigment is brown

decreased eye pigmentation ( J:100221 )

vision/eye

decreased eye pigmentation ( J:100221 )

integument

abnormal coat/hair pigmentation ( J:100221 )

• hair eumelanin pigment is brown

Allelic Composition	Tyrp1^b/Tyrp1^b-1FBleo
Genetic Background	involves: 101/Rl * C3H/Rl

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tyrp1^b mutation (29 available); any Tyrp1 mutation (162 available)
Tyrp1^b-1FBleo mutation (1 available); any Tyrp1 mutation (162 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

pigmentation

abnormal coat/hair pigmentation ( J:100221 )

• hair eumelanin pigment is brown

decreased eye pigmentation ( J:100221 )

vision/eye

decreased eye pigmentation ( J:100221 )

integument

abnormal coat/hair pigmentation ( J:100221 )

• hair eumelanin pigment is brown

Allelic Composition	Tyrp1^b/Tyrp1^b-1FCHLc
Genetic Background	involves: 101/Rl * C3H/Rl

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tyrp1^b mutation (29 available); any Tyrp1 mutation (162 available)
Tyrp1^b-1FCHLc mutation (1 available); any Tyrp1 mutation (162 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

pigmentation

abnormal coat/hair pigmentation ( J:100221 )

• hair eumelanin pigment is brown

decreased eye pigmentation ( J:100221 )

vision/eye

decreased eye pigmentation ( J:100221 )

integument

abnormal coat/hair pigmentation ( J:100221 )

• hair eumelanin pigment is brown

Allelic Composition	Tyrp1^b/Tyrp1^b-1MLP5
Genetic Background	involves: 101/Rl * C3H/Rl

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tyrp1^b mutation (29 available); any Tyrp1 mutation (162 available)
Tyrp1^b-1MLP5 mutation (1 available); any Tyrp1 mutation (162 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

pigmentation

abnormal coat/hair pigmentation ( J:100221 )

• hair eumelanin pigment is brown

decreased eye pigmentation ( J:100221 )

vision/eye

decreased eye pigmentation ( J:100221 )

integument

abnormal coat/hair pigmentation ( J:100221 )

• hair eumelanin pigment is brown

Allelic Composition	Tyrp1^b/Tyrp1^b-1OZ
Genetic Background	involves: 101/Rl * C3H/Rl

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tyrp1^b mutation (29 available); any Tyrp1 mutation (162 available)
Tyrp1^b-1OZ mutation (1 available); any Tyrp1 mutation (162 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

pigmentation

abnormal coat/hair pigmentation ( J:100221 )

• hair eumelanin pigment is brown

decreased eye pigmentation ( J:100221 )

vision/eye

decreased eye pigmentation ( J:100221 )

integument

abnormal coat/hair pigmentation ( J:100221 )

• hair eumelanin pigment is brown

Allelic Composition	Tyrp1^b/Tyrp1^b-1THO-IV
Genetic Background	involves: 101/Rl * C3H/Rl

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tyrp1^b mutation (29 available); any Tyrp1 mutation (162 available)
Tyrp1^b-1THO-IV mutation (1 available); any Tyrp1 mutation (162 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

pigmentation

abnormal coat/hair pigmentation ( J:100221 )

• hair eumelanin pigment is brown

decreased eye pigmentation ( J:100221 )

vision/eye

decreased eye pigmentation ( J:100221 )

integument

abnormal coat/hair pigmentation ( J:100221 )

• hair eumelanin pigment is brown

Allelic Composition	Tyrp1^b/Tyrp1^b-11PU
Genetic Background	involves: 101/Rl * C3H/Rl

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tyrp1^b mutation (29 available); any Tyrp1 mutation (162 available)
Tyrp1^b-11PU mutation (1 available); any Tyrp1 mutation (162 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

pigmentation

abnormal coat/hair pigmentation ( J:100221 )

• hair eumelanin pigment is brown

decreased eye pigmentation ( J:100221 )

vision/eye

decreased eye pigmentation ( J:100221 )

integument

abnormal coat/hair pigmentation ( J:100221 )

• hair eumelanin pigment is brown

Allelic Composition	Tyrp1^b/Tyrp1^b-2MLP10
Genetic Background	involves: 101/Rl * C3H/Rl

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tyrp1^b mutation (29 available); any Tyrp1 mutation (162 available)
Tyrp1^b-2MLP10 mutation (1 available); any Tyrp1 mutation (162 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

pigmentation

abnormal coat/hair pigmentation ( J:100221 )

• hair eumelanin pigment is brown

decreased eye pigmentation ( J:100221 )

vision/eye

decreased eye pigmentation ( J:100221 )

integument

abnormal coat/hair pigmentation ( J:100221 )

• hair eumelanin pigment is brown

Allelic Composition	Tyrp1^b/Tyrp1^b-2MLP7.5
Genetic Background	involves: 101/Rl * C3H/Rl

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tyrp1^b mutation (29 available); any Tyrp1 mutation (162 available)
Tyrp1^b-2MLP7.5 mutation (1 available); any Tyrp1 mutation (162 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

pigmentation

abnormal coat/hair pigmentation ( J:100221 )

• hair eumelanin pigment is brown

decreased eye pigmentation ( J:100221 )

vision/eye

decreased eye pigmentation ( J:100221 )

integument

abnormal coat/hair pigmentation ( J:100221 )

• hair eumelanin pigment is brown

Allelic Composition	Tyrp1^b/Tyrp1^b-331K
Genetic Background	involves: 101/Rl * C3H/Rl

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tyrp1^b mutation (29 available); any Tyrp1 mutation (162 available)
Tyrp1^b-331K mutation (1 available); any Tyrp1 mutation (162 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

pigmentation

abnormal coat/hair pigmentation ( J:100221 )

• hair eumelanin pigment is brown

decreased eye pigmentation ( J:100221 )

vision/eye

decreased eye pigmentation ( J:100221 )

integument

abnormal coat/hair pigmentation ( J:100221 )

• hair eumelanin pigment is brown

Allelic Composition	Tyrp1^b/Tyrp1^b-33G
Genetic Background	involves: 101/Rl * C3H/Rl

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tyrp1^b mutation (29 available); any Tyrp1 mutation (162 available)
Tyrp1^b-33G mutation (1 available); any Tyrp1 mutation (162 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

pigmentation

abnormal coat/hair pigmentation ( J:100221 )

• hair eumelanin pigment is brown

decreased eye pigmentation ( J:100221 )

vision/eye

decreased eye pigmentation ( J:100221 )

integument

abnormal coat/hair pigmentation ( J:100221 )

• hair eumelanin pigment is brown

Allelic Composition	Tyrp1^b/Tyrp1^b-37DTD
Genetic Background	involves: 101/Rl * C3H/Rl

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tyrp1^b mutation (29 available); any Tyrp1 mutation (162 available)
Tyrp1^b-37DTD mutation (1 available); any Tyrp1 mutation (162 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

pigmentation

abnormal coat/hair pigmentation ( J:100221 )

• hair eumelanin pigment is brown

decreased eye pigmentation ( J:100221 )

vision/eye

decreased eye pigmentation ( J:100221 )

integument

abnormal coat/hair pigmentation ( J:100221 )

• hair eumelanin pigment is brown

Allelic Composition	Tyrp1^b/Tyrp1^b-37FrThc
Genetic Background	involves: 101/Rl * C3H/Rl

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tyrp1^b mutation (29 available); any Tyrp1 mutation (162 available)
Tyrp1^b-37FrThc mutation (1 available); any Tyrp1 mutation (162 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

pigmentation

abnormal coat/hair pigmentation ( J:100221 )

• hair eumelanin pigment is brown

decreased eye pigmentation ( J:100221 )

vision/eye

decreased eye pigmentation ( J:100221 )

integument

abnormal coat/hair pigmentation ( J:100221 )

• hair eumelanin pigment is brown

Allelic Composition	Tyrp1^b/Tyrp1^b-37Pub
Genetic Background	involves: 101/Rl * C3H/Rl

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tyrp1^b mutation (29 available); any Tyrp1 mutation (162 available)
Tyrp1^b-37Pub mutation (1 available); any Tyrp1 mutation (162 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

pigmentation

abnormal coat/hair pigmentation ( J:100221 )

• hair eumelanin pigment is brown

decreased eye pigmentation ( J:100221 )

vision/eye

decreased eye pigmentation ( J:100221 )

integument

abnormal coat/hair pigmentation ( J:100221 )

• hair eumelanin pigment is brown

Allelic Composition	Tyrp1^b/Tyrp1^b-3CHLe
Genetic Background	involves: 101/Rl * C3H/Rl

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tyrp1^b mutation (29 available); any Tyrp1 mutation (162 available)
Tyrp1^b-3CHLe mutation (0 available); any Tyrp1 mutation (162 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

pigmentation

abnormal coat/hair pigmentation ( J:100221 )

• hair eumelanin pigment is brown

decreased eye pigmentation ( J:100221 )

growth/size/body

decreased body weight ( J:100221 )

• weight is 45% that of same-sexed littermates

reproductive system

reduced female fertility ( J:100221 )

reduced male fertility ( J:100221 )

vision/eye

decreased eye pigmentation ( J:100221 )

integument

abnormal coat/hair pigmentation ( J:100221 )

• hair eumelanin pigment is brown

Allelic Composition	Tyrp1^b/Tyrp1^b-3MLPc
Genetic Background	involves: 101/Rl * C3H/Rl

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tyrp1^b mutation (29 available); any Tyrp1 mutation (162 available)
Tyrp1^b-3MLPc mutation (1 available); any Tyrp1 mutation (162 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

pigmentation

abnormal coat/hair pigmentation ( J:100221 )

• hair eumelanin pigment is brown

decreased eye pigmentation ( J:100221 )

vision/eye

decreased eye pigmentation ( J:100221 )

integument

abnormal coat/hair pigmentation ( J:100221 )

• hair eumelanin pigment is brown

Allelic Composition	Tyrp1^b/Tyrp1^b-3YPSc
Genetic Background	involves: 101/Rl * C3H/Rl

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tyrp1^b mutation (29 available); any Tyrp1 mutation (162 available)
Tyrp1^b-3YPSc mutation (1 available); any Tyrp1 mutation (162 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

pigmentation

abnormal coat/hair pigmentation ( J:100221 )

• hair eumelanin pigment is brown

decreased eye pigmentation ( J:100221 )

vision/eye

decreased eye pigmentation ( J:100221 )

integument

abnormal coat/hair pigmentation ( J:100221 )

• hair eumelanin pigment is brown

Allelic Composition	Tyrp1^b/Tyrp1^b-3YPSh
Genetic Background	involves: 101/Rl * C3H/Rl

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tyrp1^b mutation (29 available); any Tyrp1 mutation (162 available)
Tyrp1^b-3YPSh mutation (1 available); any Tyrp1 mutation (162 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

pigmentation

abnormal coat/hair pigmentation ( J:100221 )

• hair eumelanin pigment is brown

decreased eye pigmentation ( J:100221 )

vision/eye

decreased eye pigmentation ( J:100221 )

integument

abnormal coat/hair pigmentation ( J:100221 )

• hair eumelanin pigment is brown

Allelic Composition	Tyrp1^b/Tyrp1^b-46UThc
Genetic Background	involves: 101/Rl * C3H/Rl

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tyrp1^b mutation (29 available); any Tyrp1 mutation (162 available)
Tyrp1^b-46UThc mutation (1 available); any Tyrp1 mutation (162 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

pigmentation

abnormal coat/hair pigmentation ( J:100221 )

• hair eumelanin pigment is brown

decreased eye pigmentation ( J:100221 )

vision/eye

decreased eye pigmentation ( J:100221 )

integument

abnormal coat/hair pigmentation ( J:100221 )

• hair eumelanin pigment is brown

Allelic Composition	Tyrp1^b/Tyrp1^b-47DThWb
Genetic Background	involves: 101/Rl * C3H/Rl

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tyrp1^b mutation (29 available); any Tyrp1 mutation (162 available)
Tyrp1^b-47DThWb mutation (1 available); any Tyrp1 mutation (162 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

pigmentation

abnormal coat/hair pigmentation ( J:100221 )

• hair eumelanin pigment is brown

decreased eye pigmentation ( J:100221 )

vision/eye

decreased eye pigmentation ( J:100221 )

integument

abnormal coat/hair pigmentation ( J:100221 )

• hair eumelanin pigment is brown

Allelic Composition	Tyrp1^b/Tyrp1^b-49HATh
Genetic Background	involves: 101/Rl * C3H/Rl

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tyrp1^b mutation (29 available); any Tyrp1 mutation (162 available)
Tyrp1^b-49HATh mutation (1 available); any Tyrp1 mutation (162 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

pigmentation

abnormal coat/hair pigmentation ( J:100221 )

• hair eumelanin pigment is brown

decreased eye pigmentation ( J:100221 )

vision/eye

decreased eye pigmentation ( J:100221 )

integument

abnormal coat/hair pigmentation ( J:100221 )

• hair eumelanin pigment is brown

Allelic Composition	Tyrp1^b/Tyrp1^b-4ACRg
Genetic Background	involves: 101/Rl * C3H/Rl

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tyrp1^b mutation (29 available); any Tyrp1 mutation (162 available)
Tyrp1^b-4ACRg mutation (1 available); any Tyrp1 mutation (162 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

pigmentation

abnormal coat/hair pigmentation ( J:100221 )

• hair eumelanin pigment is brown

decreased eye pigmentation ( J:100221 )

vision/eye

decreased eye pigmentation ( J:100221 )

integument

abnormal coat/hair pigmentation ( J:100221 )

• hair eumelanin pigment is brown

Allelic Composition	Tyrp1^b/Tyrp1^b-51DThWb
Genetic Background	involves: 101/Rl * C3H/Rl

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tyrp1^b mutation (29 available); any Tyrp1 mutation (162 available)
Tyrp1^b-51DThWb mutation (1 available); any Tyrp1 mutation (162 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

pigmentation

abnormal coat/hair pigmentation ( J:100221 )

• hair eumelanin pigment is brown

decreased eye pigmentation ( J:100221 )

vision/eye

decreased eye pigmentation ( J:100221 )

integument

abnormal coat/hair pigmentation ( J:100221 )

• hair eumelanin pigment is brown

Allelic Composition	Tyrp1^b/Tyrp1^b-55CoS
Genetic Background	involves: 101/Rl * C3H/Rl

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tyrp1^b mutation (29 available); any Tyrp1 mutation (162 available)
Tyrp1^b-55CoS mutation (1 available); any Tyrp1 mutation (162 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

pigmentation

abnormal coat/hair pigmentation ( J:100221 )

• hair eumelanin pigment is brown

decreased eye pigmentation ( J:100221 )

vision/eye

decreased eye pigmentation ( J:100221 )

integument

abnormal coat/hair pigmentation ( J:100221 )

• hair eumelanin pigment is brown

Allelic Composition	Tyrp1^b/Tyrp1^b-5CHLe
Genetic Background	involves: 101/Rl * C3H/Rl

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tyrp1^b mutation (29 available); any Tyrp1 mutation (162 available)
Tyrp1^b-5CHLe mutation (1 available); any Tyrp1 mutation (162 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

pigmentation

abnormal coat/hair pigmentation ( J:100221 )

• hair eumelanin pigment is brown

decreased eye pigmentation ( J:100221 )

vision/eye

decreased eye pigmentation ( J:100221 )

integument

abnormal coat/hair pigmentation ( J:100221 )

• hair eumelanin pigment is brown

Allelic Composition	Tyrp1^b/Tyrp1^b-5CHLo
Genetic Background	involves: 101/Rl * C3H/Rl

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tyrp1^b mutation (29 available); any Tyrp1 mutation (162 available)
Tyrp1^b-5CHLo mutation (1 available); any Tyrp1 mutation (162 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

pigmentation

abnormal coat/hair pigmentation ( J:100221 )

• hair eumelanin pigment is brown

decreased eye pigmentation ( J:100221 )

vision/eye

decreased eye pigmentation ( J:100221 )

integument

abnormal coat/hair pigmentation ( J:100221 )

• hair eumelanin pigment is brown

Allelic Composition	Tyrp1^b/Tyrp1^b-5MLPm
Genetic Background	involves: 101/Rl * C3H/Rl

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tyrp1^b mutation (29 available); any Tyrp1 mutation (162 available)
Tyrp1^b-5MLPm mutation (1 available); any Tyrp1 mutation (162 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

pigmentation

abnormal coat/hair pigmentation ( J:100221 )

• hair eumelanin pigment is brown

decreased eye pigmentation ( J:100221 )

vision/eye

decreased eye pigmentation ( J:100221 )

integument

abnormal coat/hair pigmentation ( J:100221 )

• hair eumelanin pigment is brown

Allelic Composition	Tyrp1^b/Tyrp1^b-5FBleb
Genetic Background	involves: 101/Rl * C3H/Rl

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tyrp1^b mutation (29 available); any Tyrp1 mutation (162 available)
Tyrp1^b-5FBleb mutation (0 available); any Tyrp1 mutation (162 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

pigmentation

abnormal coat/hair pigmentation ( J:100221 )

• hair eumelanin pigment is brown

decreased eye pigmentation ( J:100221 )

vision/eye

decreased eye pigmentation ( J:100221 )

integument

abnormal coat/hair pigmentation ( J:100221 )

• hair eumelanin pigment is brown

Allelic Composition	Tyrp1^b/Tyrp1^b-8PUb
Genetic Background	involves: 101/Rl * C3H/Rl

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tyrp1^b mutation (29 available); any Tyrp1 mutation (162 available)
Tyrp1^b-8PUb mutation (0 available); any Tyrp1 mutation (162 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

pigmentation

abnormal coat/hair pigmentation ( J:100221 )

• hair eumelanin pigment is brown

decreased eye pigmentation ( J:100221 )

vision/eye

decreased eye pigmentation ( J:100221 )

integument

abnormal coat/hair pigmentation ( J:100221 )

• hair eumelanin pigment is brown

Allelic Composition	Tyrp1^b/Tyrp1^b-9Bleo
Genetic Background	involves: 101/Rl * C3H/Rl

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tyrp1^b mutation (29 available); any Tyrp1 mutation (162 available)
Tyrp1^b-9Bleo mutation (0 available); any Tyrp1 mutation (162 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

pigmentation

abnormal coat/hair pigmentation ( J:100221 )

• hair eumelanin pigment is brown

decreased eye pigmentation ( J:100221 )

vision/eye

decreased eye pigmentation ( J:100221 )

integument

abnormal coat/hair pigmentation ( J:100221 )

• hair eumelanin pigment is brown

Allelic Composition	Tyrp1^b/Tyrp1^b-9PU
Genetic Background	involves: 101/Rl * C3H/Rl

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tyrp1^b mutation (29 available); any Tyrp1 mutation (162 available)
Tyrp1^b-9PU mutation (1 available); any Tyrp1 mutation (162 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

pigmentation

abnormal coat/hair pigmentation ( J:100221 )

• hair eumelanin pigment is brown

decreased eye pigmentation ( J:100221 )

vision/eye

decreased eye pigmentation ( J:100221 )

integument

abnormal coat/hair pigmentation ( J:100221 )

• hair eumelanin pigment is brown

Allelic Composition	Tyrp1^b/Tyrp1^b-9R75VH
Genetic Background	involves: 101/Rl * C3H/Rl

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tyrp1^b mutation (29 available); any Tyrp1 mutation (162 available)
Tyrp1^b-9R75VH mutation (1 available); any Tyrp1 mutation (162 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

pigmentation

abnormal coat/hair pigmentation ( J:100221 )

• hair eumelanin pigment is brown

decreased eye pigmentation ( J:100221 )

vision/eye

decreased eye pigmentation ( J:100221 )

integument

abnormal coat/hair pigmentation ( J:100221 )

• hair eumelanin pigment is brown

Allelic Composition	Tyrp1^B-w/Tyrp1^b
Genetic Background	involves: 101/Rl * C3H/Rl

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tyrp1^b mutation (29 available); any Tyrp1 mutation (162 available)
Tyrp1^B-w mutation (14 available); any Tyrp1 mutation (162 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

pigmentation

diluted coat color ( J:13492 , J:18590 )

• the outer two-thirds to three-quarters of the hair is brown, and the base is white (J:13492)

• pigment loss is due to premature melanocyte death (J:18590)

decreased eye pigmentation ( J:13492 )

• eye pigment resembles that of Tyrp1^b homozygotes

vision/eye

decreased eye pigmentation ( J:13492 )

• eye pigment resembles that of Tyrp1^b homozygotes

integument

diluted coat color ( J:13492 , J:18590 )

• the outer two-thirds to three-quarters of the hair is brown, and the base is white (J:13492)

• pigment loss is due to premature melanocyte death (J:18590)

Allelic Composition	Tyrp1^b/Tyrp1^b-26R60L
Genetic Background	involves: 101/Rl * C3H/Rl

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tyrp1^b mutation (29 available); any Tyrp1 mutation (162 available)
Tyrp1^b-26R60L mutation (1 available); any Tyrp1 mutation (162 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

pigmentation

abnormal coat/hair pigmentation ( J:100221 )

• hair eumelanin pigment is brown

decreased eye pigmentation ( J:100221 )

vision/eye

decreased eye pigmentation ( J:100221 )

integument

abnormal coat/hair pigmentation ( J:100221 )

• hair eumelanin pigment is brown

Allelic Composition	Tyrp1^b/Tyrp1^b-11R30M
Genetic Background	involves: 101/Rl * C3H/Rl

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tyrp1^b mutation (29 available); any Tyrp1 mutation (162 available)
Tyrp1^b-11R30M mutation (2 available); any Tyrp1 mutation (162 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

pigmentation

abnormal coat/hair pigmentation ( J:100221 )

• hair eumelanin pigment is brown

decreased eye pigmentation ( J:100221 )

vision/eye

decreased eye pigmentation ( J:100221 )

integument

abnormal coat/hair pigmentation ( J:100221 )

• hair eumelanin pigment is brown

Allelic Composition	Tyrp1^b/Tyrp1^b-12PU
Genetic Background	involves: 101/Rl * C3H/Rl

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tyrp1^b mutation (29 available); any Tyrp1 mutation (162 available)
Tyrp1^b-12PU mutation (1 available); any Tyrp1 mutation (162 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

pigmentation

abnormal coat/hair pigmentation ( J:100221 )

• hair eumelanin pigment is brown

decreased eye pigmentation ( J:100221 )

vision/eye

decreased eye pigmentation ( J:100221 )

integument

abnormal coat/hair pigmentation ( J:100221 )

• hair eumelanin pigment is brown

Allelic Composition	Tyrp1^b/Tyrp1^b-55H
Genetic Background	involves: C3H/HeH

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tyrp1^b mutation (29 available); any Tyrp1 mutation (162 available)
Tyrp1^b-55H mutation (0 available); any Tyrp1 mutation (162 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

integument

abnormal coat/hair pigmentation ( J:180879 )

• mice resemble Tryp1^b homozygotes

pigmentation

abnormal coat/hair pigmentation ( J:180879 )

• mice resemble Tryp1^b homozygotes

Allelic Composition	Tyrp1^b/Tyrp1^rgsc671
Genetic Background	involves: C57BL/6JJcl * DBA/2JJcl

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tyrp1^b mutation (29 available); any Tyrp1 mutation (162 available)
Tyrp1^rgsc671 mutation (1 available); any Tyrp1 mutation (162 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

pigmentation

abnormal coat/hair pigmentation ( J:133634 )

• compound heterozygotes for these two alleles have brown fur that is darker than that of mice homozygous for the classic brown mutation, Tyrp1^b, and lighter than that of Tyrp1^rgsc671 homozygotes

integument

abnormal coat/hair pigmentation ( J:133634 )

• compound heterozygotes for these two alleles have brown fur that is darker than that of mice homozygous for the classic brown mutation, Tyrp1^b, and lighter than that of Tyrp1^rgsc671 homozygotes

Allelic Composition	Gpnmb^R150X/Gpnmb^R150X Tyr^c-2J/Tyr^c-2J Tyrp1^b/Tyrp1^b
Genetic Background	B6.Cg-Tyrp1^b Gpnmb^R150X Tyr^c-2J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gpnmb^R150X mutation (4 available); any Gpnmb mutation (39 available)
Tyr^c-2J mutation (25 available); any Tyr mutation (375 available)
Tyrp1^b mutation (29 available); any Tyrp1 mutation (162 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Tyrosinase deficiency prevents iris disease in Gpnmb^R150X/Gpnmb^R150X Tyrp1^b/Tyrp1^b Tyr^c-2J/Tyr^c-2J mice

vision/eye

vision/eye phenotype ( J:128215 )

N	• triple mutants do not develop iris disease as seen in double Gpnmb^R150X and Tyrp1^bmice

Allelic Composition	Gpnmb^R150X/Gpnmb^R150X Tyrp1^b/Tyrp1^b
Genetic Background	B6.D2-Tyrp1^b Gpnmb^R150X

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gpnmb^R150X mutation (4 available); any Gpnmb mutation (39 available)
Tyrp1^b mutation (29 available); any Tyrp1 mutation (162 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Gpnmb^R150X/Gpnmb^R150X Tyrp1^b/Tyrp1^b mice develop a severe iris disease

vision/eye

abnormal iris morphology ( J:128215 )

• double mutants develop iris disease that is first noticeable by 6 months of age, when all eyes show slight swelling of peripupillary tissue

• at 12, 14, and 18 months of age, increasing degree of iris atrophy is observed, that includes full-thickness iris holes, profound transillumination, pigment dispersion and frequent pigment accumulation on the lens and cornea, and changes to the dimensions of the anterior chamber

• however, mutants do not develop glaucomatus nerve damage that is seen in DBA/2J mice

abnormal iris pigmentation ( J:128215 )

• severe pigment dispersing iris disease

• timing and severity of pigment dispersing iris disease is similar to that seen in either single mutant on a DBA/2J background

iris atrophy ( J:128215 )

• atrophy is seen by 6-9 months of age

abnormal intraocular pressure ( J:128215 )

• double mutants are less susceptible to intraocular pressure elevation than DBA/2J mice

pigmentation

abnormal iris pigmentation ( J:128215 )

• severe pigment dispersing iris disease

• timing and severity of pigment dispersing iris disease is similar to that seen in either single mutant on a DBA/2J background

Allelic Composition	a/a Mlph^ln/Mlph^ln Tyrp1^b/Tyrp1^b
Genetic Background	C57L/J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
a mutation (229 available); any a mutation (463 available)
Mlph^ln mutation (6 available); any Mlph mutation (38 available)
Tyrp1^b mutation (29 available); any Tyrp1 mutation (162 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

pigmentation

abnormal coat/hair pigmentation ( J:5095 )

diluted coat color ( J:5095 )

• due to clumping of pigment

abnormal melanocyte morphology ( J:5095 )

• results in clumping rather than even distribution of pigment during hair development

integument

abnormal coat/hair pigmentation ( J:5095 )

diluted coat color ( J:5095 )

• due to clumping of pigment

Allelic Composition	a/a Lyst^bg/Lyst^bg Tyrp1^b/Tyrp1^b
Genetic Background	involves: C3H/Rl * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
a mutation (229 available); any a mutation (463 available)
Lyst^bg mutation (6 available); any Lyst mutation (225 available)
Tyrp1^b mutation (29 available); any Tyrp1 mutation (162 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

pigmentation

abnormal choroid melanin granule morphology ( J:5346 )

• 80% of premelanosomes in the choroid and retina fuse to form giant granules

abnormal retina melanin granule morphology ( J:5346 )

• 80% of premelanosomes in the choroid and retina fuse to form giant granules

vision/eye

abnormal choroid melanin granule morphology ( J:5346 )

• 80% of premelanosomes in the choroid and retina fuse to form giant granules

abnormal retina melanin granule morphology ( J:5346 )

• 80% of premelanosomes in the choroid and retina fuse to form giant granules

Allelic Composition	a/a Tyrp1^b/Tyrp1^b
Genetic Background	involves: C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
a mutation (229 available); any a mutation (463 available)
Tyrp1^b mutation (29 available); any Tyrp1 mutation (162 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

pigmentation

abnormal melanosome morphology ( J:5346 )

• reorganization of fibrillar melanosomes into particulate melanin granules, such that 20% of granules in the choroid are particulate

Allelic Composition	Rgsc58/Rgsc58⁺ Tyrp1^b/Tyrp1^b
Genetic Background	involves: C57BL/6JJcl * DBA/2JJcl

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rgsc58 mutation (1 available); any Rgsc58 mutation (1 available)
Tyrp1^b mutation (29 available); any Tyrp1 mutation (162 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

pigmentation

white spotting ( J:133634 )

• Background Sensitivity: agouti or nonagouti brown mice heterozygous for this mutation exhibit a white band-like or spotted pattern across the dorsal lumbar region

integument

white spotting ( J:133634 )

• Background Sensitivity: agouti or nonagouti brown mice heterozygous for this mutation exhibit a white band-like or spotted pattern across the dorsal lumbar region

Allelic Composition	Lyst^bg-slt/Lyst^bg-slt Myo5a^d/Myo5a^d Oca2^p/Oca2^p Tyrp1^b/Tyrp1^b
Genetic Background	involves: CT/Ch * YZ57/Ch

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lyst^bg-slt mutation (0 available); any Lyst mutation (225 available)
Myo5a^d mutation (105 available); any Myo5a mutation (265 available)
Oca2^p mutation (11 available); any Oca2 mutation (67 available)
Tyrp1^b mutation (29 available); any Tyrp1 mutation (162 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

pigmentation

diluted coat color ( J:83269 )

integument

diluted coat color ( J:83269 )

premature hair loss ( J:83269 )

• random thinning of the coat appeared during the third week of age

abnormal hair cycle ( J:83269 )

delayed hair regrowth ( J:83269 )

• coat thinning at three weeks of age was followed by a short lag in the second hair growth cycle

Allelic Composition	A/? Lyst^bg/Lyst^bg Tyrp1^b/Tyrp1^b
Genetic Background	Not Specified

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
A mutation (19 available); any a mutation (463 available)
Lyst^bg mutation (6 available); any Lyst mutation (225 available)
Tyrp1^b mutation (29 available); any Tyrp1 mutation (162 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

pigmentation

diluted coat color ( J:29744 )

• on an agouti brown (A-bb) background, beige mice exhibit an overall cafe-au-lait coat color

• Background Sensitivity: the relatively greater dilution effect noted on basal hair is not as pronounced in brown beige as in black beige mice

decreased eye pigmentation ( J:29744 )

• Background Sensitivity: on an agouti brown (A-bb) background, newborn beige mice exhibit lighter eyes than on an agouti black (A-B-) background

vision/eye

decreased eye pigmentation ( J:29744 )

• Background Sensitivity: on an agouti brown (A-bb) background, newborn beige mice exhibit lighter eyes than on an agouti black (A-B-) background

integument

diluted coat color ( J:29744 )

• on an agouti brown (A-bb) background, beige mice exhibit an overall cafe-au-lait coat color

• Background Sensitivity: the relatively greater dilution effect noted on basal hair is not as pronounced in brown beige as in black beige mice

Allelic Composition	a/a Tyrp1^b/Tyrp1^b wad/wad⁺
Genetic Background	Not Specified

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

pigmentation

diluted coat color ( J:162146 )

• Background Sensitivity: whereas heterozygosity for this mutation has no apparent effect on the agouti (A/A) background of C3H/W, on this nonagouti brown background, the coat color of mice heterozygous for wad is obviously diluted--the shade of milk chocolate versus the dark brown of wild-type animals--with occasional, interspersed darker hairs

integument

diluted coat color ( J:162146 )

Allelic Composition	a/a Tyrp1^b/Tyrp1^b wad/wad
Genetic Background	Not Specified

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

pigmentation

diluted coat color ( J:162146 )

• on this background, as on the agouti background of C3H/W, the coat color of mice homozygous for this mutation is significantly diluted, appearing pale buff with occasional, interspersed darker hairs

integument

diluted coat color ( J:162146 )

Allelic Composition	a/a Tyrp1^b/Tyrp1^b
Genetic Background	Not Specified

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

integument

abnormal coat/hair pigmentation ( J:12970 )

• eunmelanin is brown rather than black

pigmentation

abnormal coat/hair pigmentation ( J:12970 )

• eunmelanin is brown rather than black

abnormal eye pigmentation ( J:12970 )

• eunmelanin is brown rather than black

abnormal melanocyte morphology ( J:12970 )

• cell shape is spheroid rather than ovoid

vision/eye

abnormal eye pigmentation ( J:12970 )

• eunmelanin is brown rather than black

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/16/2024 MGI 6.23