Phenotypes associated with this allele
Allelic
Composition |
at/at
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Genetic
Background |
Not Specified |
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
at mutation
(8 available);
any
a mutation
(463 available)
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pigmentation
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• some yellow pigment is found in hairs originating on or behind the ears
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• mice have a black dorsum and yellow or cream belly; at is dominant to A allele on the ventrum but recessive to A on the dorsum
(J:22600)
• belly of animal is white, cream, or tan (yellow) in color; hairs originating on ventrum may be frequently nonpigmented, possess yellow pigment or are predominantly yellow with black bases compared to A/A mice
(J:78801)
• Aw is dominant to A and all lower alleles
(J:78801)
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integument
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• some yellow pigment is found in hairs originating on or behind the ears
|
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• mice have a black dorsum and yellow or cream belly; at is dominant to A allele on the ventrum but recessive to A on the dorsum
(J:22600)
• belly of animal is white, cream, or tan (yellow) in color; hairs originating on ventrum may be frequently nonpigmented, possess yellow pigment or are predominantly yellow with black bases compared to A/A mice
(J:78801)
• Aw is dominant to A and all lower alleles
(J:78801)
|
Allelic
Composition |
at/atl
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Genetic
Background |
involves: 101/H * C3H/HeH |
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pigmentation
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• looks like atl homozygotes
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integument
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• looks like atl homozygotes
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Pigmentation phenotype of the Tbx15de-H/Tbx15de-H ae/ae mouse
pigmentation
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• the thin stripe of yellow hair that normally separates the dorsal black hairs from the ventral cream hairs in at mice is extended dorsally and the boundary between the yellow and the black hairs is fuzzier
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• resembles pattern of a black-and-tan (at) mutation
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• abnormal dorsoventral pigment patterning with proportion of body circumference occupied by the lateral region increased 2-fold over normal patterning and the proportion of the ventral cream-colored region expanding a small amount, 47.9% compared to 37.8% in at
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craniofacial
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• elevated skull contributes lowered ear position with pinnae projecting laterally
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vision/eye
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• results in widely spaced eyes
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• small palpebral fissures noted
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growth/size/body
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• elevated skull contributes lowered ear position with pinnae projecting laterally
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hearing/vestibular/ear
integument
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• the thin stripe of yellow hair that normally separates the dorsal black hairs from the ventral cream hairs in at mice is extended dorsally and the boundary between the yellow and the black hairs is fuzzier
|
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• resembles pattern of a black-and-tan (at) mutation
|
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• abnormal dorsoventral pigment patterning with proportion of body circumference occupied by the lateral region increased 2-fold over normal patterning and the proportion of the ventral cream-colored region expanding a small amount, 47.9% compared to 37.8% in at
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respiratory system
Allelic
Composition |
at/A
As/As+
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Genetic
Background |
Not Specified |
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pigmentation
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• only the agouti allele on the same chromosome as the As allele is affected
• the expected cream belly is not seen for this genotype; the mouse looks normal agouti
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integument
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• only the agouti allele on the same chromosome as the As allele is affected
• the expected cream belly is not seen for this genotype; the mouse looks normal agouti
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Allelic
Composition |
at/at
As/As
|
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Genetic
Background |
Not Specified |
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
As mutation
(0 available);
any
As mutation
(0 available)
at mutation
(8 available);
any
a mutation
(463 available)
|
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pigmentation
|
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• unable to distinguish from homozygous ae mice
|
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• the entire coat is dark-agouti; a cream belly is normally found on mice that are homozygous for at
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integument
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• unable to distinguish from homozygous ae mice
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• the entire coat is dark-agouti; a cream belly is normally found on mice that are homozygous for at
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Allelic
Composition |
Aw/at
As/As+
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Genetic
Background |
Not Specified |
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pigmentation
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• this allele only affects the agouti allele present on the same chromosome
• this genotype results in normal light-bellied agouti; not the anticipated cream color from the at allele and seen in a mouse genotype AsAw/As<+>at
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integument
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• this allele only affects the agouti allele present on the same chromosome
• this genotype results in normal light-bellied agouti; not the anticipated cream color from the at allele and seen in a mouse genotype AsAw/As<+>at
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Analysis Tools