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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
ae
extreme nonagouti
MGI:1855939
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
ae/ae (P x S)F1 MGI:3611281
ht2
ax/ae B6.Cg-ax MGI:5142469
ht3
a16H/ae involves: 101/H * C3H/HeH * P * S MGI:4361533
cx4
ae/ae
Tbx15de-H/Tbx15de-H
involves: BTBR * C3H/HeJ * C57BL/6 * P * S MGI:3767626


Genotype
MGI:3611281
hm1
Allelic
Composition
ae/ae
Genetic
Background
(P x S)F1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
ae mutation (4 available); any a mutation (460 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
pigmentation
• black is more intense than homozygous non-agouti
• no yellow hairs in the ears or around nipples and perineum as found in homozygous non-agouti mice

integument
• black is more intense than homozygous non-agouti
• no yellow hairs in the ears or around nipples and perineum as found in homozygous non-agouti mice




Genotype
MGI:5142469
ht2
Allelic
Composition
ax/ae
Genetic
Background
B6.Cg-ax
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
ae mutation (4 available); any a mutation (460 available)
ax mutation (0 available); any a mutation (460 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
integument
• the belly is lighter than seen for a/a or ae/ae mice

pigmentation
• the belly is lighter than seen for a/a or ae/ae mice




Genotype
MGI:4361533
ht3
Allelic
Composition
a16H/ae
Genetic
Background
involves: 101/H * C3H/HeH * P * S
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
a16H mutation (1 available); any a mutation (460 available)
ae mutation (4 available); any a mutation (460 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
pigmentation
• normal nonagouti black on back but lighter, agouti belly
• black, rather than yellow, pinna hair

integument
• normal nonagouti black on back but lighter, agouti belly
• black, rather than yellow, pinna hair




Genotype
MGI:3767626
cx4
Allelic
Composition
ae/ae
Tbx15de-H/Tbx15de-H
Genetic
Background
involves: BTBR * C3H/HeJ * C57BL/6 * P * S
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
ae mutation (4 available); any a mutation (460 available)
Tbx15de-H mutation (1 available); any Tbx15 mutation (34 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Dorsal skin pigmentation of Tbx15de-H/Tbx15de-H neonates

growth/size/body

pigmentation
• the extent of dorsal skin pigmentation is reduced in neonates; unlike in ae mice where neonatal skin appears uniformly dark over the entire dorsum, in double mutants, the area of dark skin is more restricted, particularly above the limbs and resembles the pattern of dorsal eumelanin in at Tbx15de-H double homozygous mutants

skeleton
• skeletal abnormalities

integument
N
• display no coat-color phenotype
• small but consistent reduction in hair length in both dorsum and ventrum; reduced hair is most apparent in the lateral region
• the extent of dorsal skin pigmentation is reduced in neonates; unlike in ae mice where neonatal skin appears uniformly dark over the entire dorsum, in double mutants, the area of dark skin is more restricted, particularly above the limbs and resembles the pattern of dorsal eumelanin in at Tbx15de-H double homozygous mutants





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last database update
01/18/2022
MGI 6.17
The Jackson Laboratory