Trem2^tm1.1Cya
Targeted Allele Detail

Summary

• Symbol: Trem2^tm1.1Cya
• Name: triggering receptor expressed on myeloid cells 2; targeted mutation 1.1, Cyagen Biosciences
• MGI ID: MGI:7516532
• Synonyms: Trem2 R47H
• Gene: Trem2 Location: Chr17:48653429-48659304 bp, + strand Genetic Position: Chr17, 23.99 cM, cytoband C
• Alliance: Trem2^tm1.1Cya page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:304182
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Targeted (Humanized sequence)
• Mutations: Insertion, Single point mutation
• Mutation details: Arginine codon 47 (CGC) in exon 2 was changed to histidine CAC (NM_031254.3:c.140 G>A, p.R47H) and a loxP site flanked neomycin resistance gene cassette was inserted into intron 2. The neo cassette was removed through subsequent Cre-mediated recombination. The mutation is the equivalent of the same human mutation associated with Alzheimer's disease (AD). (J:304182)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Trem2 Mutation: 65 strains or lines available

References

• Original: J:304182 Rong Z, et al., Activation of FAK/Rac1/Cdc42-GTPase signaling ameliorates impaired microglial migration response to Abeta42 in triggering receptor expressed on myeloid cells 2 loss-of-function murine models. FASEB J. 2020 Aug;34(8):10984-10997
• All: 1 reference(s)