Shc1^tm1.1Matz
Targeted Allele Detail

Summary

• Symbol: Shc1^tm1.1Matz
• Name: src homology 2 domain-containing transforming protein C1; targeted mutation 1.1, Rachel L Matz
• MGI ID: MGI:7424865
• Synonyms: ShcA^flox
• Gene: Shc1 Location: Chr3:89325858-89337336 bp, + strand Genetic Position: Chr3, 39.11 cM
• Alliance: Shc1^tm1.1Matz page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:217881
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: Ttwo loxP sites flanking exons 2 to 7 and a PKG neomycin resistance cassette flanked by two FRT sites were inserted into the Shc1 locus. Th neomycin resistance cassette was excised by crossing with mice expressing flippase recombinase. (J:217881)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Shc1 Mutation: 66 strains or lines available

References

• Original: J:217881 Mlih M, et al., The Src Homology and Collagen A (ShcA) Adaptor Protein Is Required for the Spatial Organization of the Costamere/Z-disk Network during Heart Development. J Biol Chem. 2015 Jan 23;290(4):2419-30
• All: 2 reference(s)