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Shc1tm1.1Matz
Targeted Allele Detail
Summary
Symbol: Shc1tm1.1Matz
Name: src homology 2 domain-containing transforming protein C1; targeted mutation 1.1, Rachel L Matz
MGI ID: MGI:7424865
Synonyms: ShcAflox
Gene: Shc1  Location: Chr3:89325858-89337336 bp, + strand  Genetic Position: Chr3, 39.11 cM
Alliance: Shc1tm1.1Matz page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:217881
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Conditional ready)
Mutation:    Insertion
 
Mutation detailsTtwo loxP sites flanking exons 2 to 7 and a PKG neomycin resistance cassette flanked by two FRT sites were inserted into the Shc1 locus. Th neomycin resistance cassette was excised by crossing with mice expressing flippase recombinase. (J:217881)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Shc1 Mutation:  65 strains or lines available
References
Original:  J:217881 Mlih M, et al., The Src Homology and Collagen A (ShcA) Adaptor Protein Is Required for the Spatial Organization of the Costamere/Z-disk Network during Heart Development. J Biol Chem. 2015 Jan 23;290(4):2419-30
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/25/2025
MGI 6.24
The Jackson Laboratory