Zic2^em2Krc
Endonuclease-mediated Allele Detail

Summary

• Symbol: Zic2^em2Krc
• Name: zinc finger protein of the cerebellum 2; endonuclease-mediated mutation 2, Kenneth R Chien
• MGI ID: MGI:7293299
• Synonyms: mutant 2
• Gene: Zic2 Location: Chr14:122712847-122717264 bp, + strand Genetic Position: Chr14, 65.97 cM
• Alliance: Zic2^em2Krc page

Mutation origin

• Strain of Origin: (C57BL/6 x DBA/2)F1

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Two guide RNAs, approximately 500bp apart from each other, were designed to target the exon 1 of the murine Zic2 gene via CRISPR. (J:306173)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Zic2 Mutation: 41 strains or lines available

References

• Original: J:306173 Xu J, et al., Genome-wide CRISPR screen identifies ZIC2 as an essential gene that controls the cell fate of early mesodermal precursors to human heart progenitors. Stem Cells. 2020 Jun;38(6):741-755
• All: 1 reference(s)