Fbxl19^tm1.2Hko
Targeted Allele Detail

Summary

• Symbol: Fbxl19^tm1.2Hko
• Name: F-box and leucine-rich repeat protein 19; targeted mutation 1.2, Haruhiko Koseki
• MGI ID: MGI:6838372
• Synonyms: Fbxl19^deltaCXXC
• Gene: Fbxl19 Location: Chr7:127343715-127368655 bp, + strand Genetic Position: Chr7, 69.71 cM
• Alliance: Fbxl19^tm1.2Hko page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:316372
• Parent Cell Line: M1/M-1 (ES Cell)
• Strain of Origin: (129 x C57BL/6)F1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The targeting construct floxed exon 2, which encodes the ZF-CxxC domain. Flp-mediated recombination removed the FRT-flanked selection cassette. Cre-mediated mutation removed exon 2. (J:316372)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fbxl19 Mutation: 16 strains or lines available

References

• Original: J:316372 Dimitrova E, et al., FBXL19 recruits CDK-Mediator to CpG islands of developmental genes priming them for activation during lineage commitment. Elife. 2018 May 29;7:e37084
• All: 1 reference(s)