Wfdc2^tm1.1Ohbo
Targeted Allele Detail

Summary

• Symbol: Wfdc2^tm1.1Ohbo
• Name: WAP four-disulfide core domain 2; targeted mutation 1.1, Kazuyuki Ohbo
• MGI ID: MGI:6728533
• Synonyms: Wfdc2^GFP
• Gene: Wfdc2 Location: Chr2:164404635-164410430 bp, + strand Genetic Position: Chr2, 85.2 cM, cytoband H3
• Alliance: Wfdc2^tm1.1Ohbo page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:282576
• Parent Cell Line: TT2 (ES Cell)
• Strain of Origin: (C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: An IRES-EGFP and loxP-flanked PGK-neomycin replaced part of exon 1 and exon 2. Cre-mediated recombination removed the drug resistance gene. (J:282576)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Wfdc2 Mutation: 17 strains or lines available

References

• Original: J:282576 Nakajima K, et al., Lack of whey acidic protein (WAP) four-disulfide core domain protease inhibitor 2 (WFDC2) causes neonatal death from respiratory failure in mice. Dis Model Mech. 2019 Nov 12;12(11):dmm040139
• All: 1 reference(s)