Trem2^em4Adiuj
Endonuclease-mediated Allele Detail

Summary

• Symbol: Trem2^em4Adiuj
• Name: triggering receptor expressed on myeloid cells 2; endonuclease-mediated mutation 4, MODEL-AD Center
• MGI ID: MGI:6721381
• Synonyms: Trem2*R47H^HSS
• Gene: Trem2 Location: Chr17:48653429-48659304 bp, + strand Genetic Position: Chr17, 23.99 cM, cytoband C
• Alliance: Trem2^em4Adiuj page

Mutation origin

• Strain of Origin: B6(SJL)-Apoe^{tm1.1(APOE*4)Adiuj} Trem2^em1Adiuj/J

Mutation description

• Allele Type: Endonuclease-mediated (Humanized sequence)
• Mutation: Nucleotide substitutions
• Mutation details: CRISPR/cas9 genome editing is used to create an R47H mutation with two silent mutations and "humanized" cryptic splice acceptor site in exon 2. The R47H mutation is one of the strongest genetic risk factors for late-onset Alzheimer's disease. (J:101977)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Trem2 Mutation: 65 strains or lines available

References

• Original: J:101977 The Jackson Laboratory, Information obtained from The Jackson Laboratory, Bar Harbor, ME. Unpublished. 2005-2017
• All: 1 reference(s)