About   Help   FAQ
Endonuclease-mediated Allele Detail
Symbol: Trem2em4Adiuj
Name: triggering receptor expressed on myeloid cells 2; endonuclease-mediated mutation 4, MODEL-AD Center
MGI ID: MGI:6721381
Synonyms: Trem2*R47HHSS
Gene: Trem2  Location: Chr17:48653429-48659304 bp, + strand  Genetic Position: Chr17, 23.99 cM, cytoband C
Strain of Origin:  B6(SJL)-Apoetm1.1(APOE*4)Adiuj Trem2em1Adiuj/J
Allele Type:    Endonuclease-mediated (Humanized sequence)
Mutation:    Nucleotide substitutions
Mutation detailsCRISPR/cas9 genome editing is used to create an R27H mutation with two silent mutations and "humanized" cryptic splice acceptor site in exon 2. The R27H mutation is one of the strongest genetic risk factors for late-onset Alzheimer's disease. (J:101977)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Trem2 Mutation:  59 strains or lines available
Original:  J:101977 The Jackson Laboratory, Information obtained from The Jackson Laboratory, Bar Harbor, ME. Unpublished. 2005-2017;
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
MGI 6.17
The Jackson Laboratory