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Trem2em4Adiuj
Endonuclease-mediated Allele Detail
Nomenclature
Symbol: Trem2em4Adiuj
Name: triggering receptor expressed on myeloid cells 2; endonuclease-mediated mutation 4, MODEL-AD Center
MGI ID: MGI:6721381
Synonyms: Trem2*R47HHSS
Gene: Trem2  Location: Chr17:48653429-48659304 bp, + strand  Genetic Position: Chr17, 23.99 cM, cytoband C
Mutation
origin
Strain of Origin:  B6(SJL)-Apoetm1.1(APOE*4)Adiuj Trem2em1Adiuj/J
Mutation
description
Allele Type:    Endonuclease-mediated (Humanized sequence)
Mutation:    Nucleotide substitutions
 
Mutation detailsCRISPR/cas9 genome editing is used to create an R27H mutation with two silent mutations and "humanized" cryptic splice acceptor site in exon 2. The R27H mutation is one of the strongest genetic risk factors for late-onset Alzheimer's disease. (J:101977)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Trem2 Mutation:  59 strains or lines available
References
Original:  J:101977 The Jackson Laboratory, Information obtained from The Jackson Laboratory, Bar Harbor, ME. Unpublished. 2005-2017;
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/21/2021
MGI 6.17
The Jackson Laboratory