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Colgalt1tm1.1Gpt
Targeted Allele Detail
Summary
Symbol: Colgalt1tm1.1Gpt
Name: collagen beta(1-O)galactosyltransferase 1; targeted mutation 1, GemPharmatech, Co., Ltd
MGI ID: MGI:6694288
Gene: Colgalt1  Location: Chr8:72063642-72077555 bp, + strand  Genetic Position: Chr8, 34.43 cM
Alliance: Colgalt1tm1.1Gpt page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:283330
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA loxP site was inserted upstream of exon 2 and an FRT flanked neo cassette and second loxP site were inserted downstream of exon 3 via homologous recombination. Cre mediated recombination removed exons 2 and 3 and the neo cassette. Western blot analysis confirmed the absence of protein expression in homozygous embryos at E10.5. (J:283330)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 13 assay results
In Structures Affected by this Mutation: 4 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Colgalt1 Mutation:  25 strains or lines available
References
Original:  J:283330 He L, et al., Down-regulation of GLT25D1 inhibited collagen secretion and involved in liver fibrogenesis. Gene. 2020 Mar 1;729:144233
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory