Tg(CAG-cat,-Trim8)4Holi
Transgene Detail

Summary

• Symbol: Tg(CAG-cat,-Trim8)4Holi
• Name: transgene insertion 4, Hongliang Li
• MGI ID: MGI:6693494
• Synonyms: CAG-CAT-TRIM8
• Transgene: Tg(CAG-cat,-Trim8)4Holi Location: unknown
• Alliance: Tg(CAG-cat,-Trim8)4Holi page

Transgene origin

• Strain of Origin: C57BL/6J

Transgene description

• Transgene Type: Transgenic (Conditional ready, Inserted expressed sequence)
• Mutation: Insertion
• Tg(CAG-cat,-Trim8)4Holi expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Trim8 (MGI:1933302)	mouse cDNA only expressed if upstream floxed cat gene is removed

• Mutation details: The transgene contains the following elements: the CAG promoter, a loxP site, a cat (chloramphenicol acetyltransferase) gene and polyA signal sequences, a second loxP site, and a mouse Trim8 cDNA and polyA signal sequences. This transgene allele normally expresses the cat gene: only after cre-mediated removal of the cat gene will it express the Trim8 gene. Four mouse lines (1-4) were established and line 4, which has the highest increase in Trim8 peptide expression after induction, was selected for further study. (J:303651)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:303651 Chen L, et al., Tripartite Motif 8 Contributes to Pathological Cardiac Hypertrophy Through Enhancing Transforming Growth Factor beta-Activated Kinase 1-Dependent Signaling Pathways. Hypertension. 2017 Feb;69(2):249-258
• All: 1 reference(s)