Lmbrd1^tm1.1Bvs
Targeted Allele Detail

Summary

• Symbol: Lmbrd1^tm1.1Bvs
• Name: LMBR1 domain containing 1; targeted mutation 1.1, Boris V Skryabin
• MGI ID: MGI:6682025
• Gene: Lmbrd1 Location: Chr1:24717711-24805382 bp, + strand Genetic Position: Chr1, 10.18 cM
• Alliance: Lmbrd1^tm1.1Bvs page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:302463
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: (129/Sv x C57BL/6J)F1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance cassette with a 5 prime loxP site was inserted upstream of exon 3. An additional loxP site was inserted downstream of exon 3. Cre-mediated recombination removed exon 3 and the selection cassette. (J:302463)

Expression

In Mice Carrying this Mutation:	14 assay results
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lmbrd1 Mutation: 37 strains or lines available

Notes

ES cells = CV19 (129/Sv x C57BL/6J)F1

References

• Original: J:302463 Buers I, et al., Lmbrd1 expression is essential for the initiation of gastrulation. J Cell Mol Med. 2016 Aug;20(8):1523-33
• All: 1 reference(s)