About   Help   FAQ
Dhcr7tm1.1Sbpa
Targeted Allele Detail
Nomenclature
Symbol: Dhcr7tm1.1Sbpa
Name: 7-dehydrocholesterol reductase; targeted mutation 1.1, Shailendra B Patel
MGI ID: MGI:6515762
Synonyms: Dhcr7flx
Gene: Dhcr7  Location: Chr7:143376882-143402147 bp, + strand  Genetic Position: Chr7, 88.33 cM, cytoband F5
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:303316
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  C57BL/6N
Mutation
description
Allele Type:    Targeted (Conditional ready)
Mutation:    Insertion
 
Mutation detailsExon 8 was flanked by loxP sites and a neomycin cassette flanked by FRT sites was inserted downstream of exon 1 but before the second loxP site. Flp-mediated recombination removed the neomycin cassette leaving exon 8 floxed. (J:303316)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
Loading...
Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Dhcr7 Mutation:  27 strains or lines available
References
Original:  J:303316 Kanuri B, et al., Generation and validation of a conditional knockout mouse model for the study of the Smith-Lemli-Opitz syndrome. J Lipid Res. 2020 Nov 22;62:100002
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
01/18/2022
MGI 6.17
The Jackson Laboratory