Usp20^em1Gpt
Endonuclease-mediated Allele Detail

Summary

• Symbol: Usp20^em1Gpt
• Name: ubiquitin specific peptidase 20; endonuclease-mediated mutation 1, GemPharmatech Co., Ltd
• MGI ID: MGI:6515593
• Synonyms: Usp20^em1Cflox
• Gene: Usp20 Location: Chr2:30872291-30912667 bp, + strand Genetic Position: Chr2, 21.77 cM, cytoband B
• Alliance: Usp20^em1Gpt page

Mutation origin

• Strain of Origin: C57BL/6JGpt

Mutation description

• Allele Type: Endonuclease-mediated (Conditional ready, No functional change)
• Mutation: Insertion
• CRISPR-targeting with a donor plasmid inserted loxP sites flanking exon 7 and 8. (J:299971)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Usp20 Mutation: 49 strains or lines available

References

• Original: J:299971 Lu XY, et al., Feeding induces cholesterol biosynthesis via the mTORC1-USP20-HMGCR axis. Nature. 2020 Dec;588(7838):479-484
• All: 1 reference(s)