Abcg4^tm1.1Sbpa
Targeted Allele Detail

Summary

• Symbol: Abcg4^tm1.1Sbpa
• Name: ATP binding cassette subfamily G member 4; targeted mutation 1.1, Shailendra Patel
• MGI ID: MGI:6513050
• Synonyms: Abcg4 KO
• Gene: Abcg4 Location: Chr9:44184485-44199912 bp, - strand Genetic Position: Chr9, 24.84 cM, cytoband A5.3
• Alliance: Abcg4^tm1.1Sbpa page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:255568
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: The targeting vector is designed to insert a loxP-flanked neomycin cassette and an EGFP reporter onto a portion of exon 7 (prior to the transmembrane domains) and to replace all of exon 8. Northern analysis of liver, lung, spleen, heart, eye, brain, testes, and kidney detected multiple short transcripts. Cre-mediated recombination removed the floxed neo cassette. The EGFP reporter does not appear to express. (J:255568)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Abcg4 Mutation: 36 strains or lines available

References

• Original: J:255568 Dodacki A, et al., Expression and function of Abcg4 in the mouse blood-brain barrier: role in restricting the brain entry of amyloid-beta peptide. Sci Rep. 2017 Oct 17;7(1):13393
• All: 1 reference(s)