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Tpsg1tm1.2Rls
Targeted Allele Detail
Summary
Symbol: Tpsg1tm1.2Rls
Name: tryptase gamma 1; targeted mutation 1.2, Richard L Stevens
MGI ID: MGI:6508397
Synonyms: Prss31-
Gene: Tpsg1  Location: Chr17:25588235-25593417 bp, + strand  Genetic Position: Chr17, 12.53 cM, cytoband A3.3
Alliance: Tpsg1tm1.2Rls page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:243813
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  C57BL/6
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA loxP site was placed 1.9 kb upstream of the first exon. A second loxP site was placed in the first intron. A puromycin resistance (PuroR) gene flanked by F3 sites was inserted into intron 1 upstream of the second loxP site for positive selection. The puromycin resistance (PuroR) gene was removed via flp1-mediated recombination and exon 1 was removed via cre-mediated recombination in the germline. (J:243813)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tpsg1 Mutation:  28 strains or lines available
References
Original:  J:243813 Hansbro PM, et al., Importance of mast cell Prss31/transmembrane tryptase/tryptase-gamma in lung function and experimental chronic obstructive pulmonary disease and colitis. J Biol Chem. 2014 Jun 27;289(26):18214-27
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory