About   Help   FAQ
Matr3em3Tcp
Endonuclease-mediated Allele Detail
Summary
Symbol: Matr3em3Tcp
Name: matrin 3; endonuclease-mediated mutation 3, The Centre for Phenogenomics
MGI ID: MGI:6500996
Synonyms: em3 p.L122Wfs*5
Gene: Matr3  Location: Chr18:35695191-35726888 bp, + strand  Genetic Position: Chr18, 19.14 cM, cytoband C
Alliance: Matr3em3Tcp page
Mutation
origin
Strain of Origin:  C57BL/6J
Mutation
description
Allele Type:    Endonuclease-mediated (Null/knockout)
Mutation:    Insertion
 
Mutation detailsCRISPR/Cas9 technology generated a 10 bp insertion (TTTTGGCCAG) at leucine 122 resulting in a frameshift and introduced a premature stop codon. (J:298091)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Matr3 Mutation:  110 strains or lines available
References
Original:  J:298091 Kao CS, et al., Selective neuronal degeneration in MATR3 S85C knock-in mouse model of early-stage ALS. Nat Commun. 2020 Oct 20;11(1):5304
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
03/19/2024
MGI 6.23
The Jackson Laboratory