Alkbh7^tm1.1Klng
Targeted Allele Detail

Summary

• Symbol: Alkbh7^tm1.1Klng
• Name: alkB homolog 7; targeted mutation 1.1, Arne Klungland
• MGI ID: MGI:6492321
• Synonyms: Alkbh7^-
• Gene: Alkbh7 Location: Chr17:57304339-57306322 bp, + strand Genetic Position: Chr17, 29.61 cM, cytoband E1.1
• Alliance: Alkbh7^tm1.1Klng page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:198968
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site and a neomycin resistance gene cassette were inserted into intron 1 and a second loxP site downstream of exon 4. Exons 2-4 were deleted through subsequent cre-mediated recombination. Western blot experiments confirmed the absence of protein expression from this allele. (J:198968)

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Alkbh7 Mutation: 14 strains or lines available

Notes

Created by GenOway.

References

• Original: J:198968 Solberg A, et al., Deletion of mouse Alkbh7 leads to obesity. J Mol Cell Biol. 2013 Jun;5(3):194-203
• All: 3 reference(s)