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Coasytm1.1Vtr
Targeted Allele Detail
Nomenclature
Symbol: Coasytm1.1Vtr
Name: Coenzyme A synthase; targeted mutation 1.1, Valeria Tiranti
MGI ID: MGI:6491679
Synonyms: Coasyflox
Gene: Coasy  Location: Chr11:100973391-100977445 bp, + strand  Genetic Position: Chr11, 64.17 cM, cytoband D
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:299154
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsThe ETPG00282_Y_2_E03 IMPC vector inserted an FRT site, lacZ reporer gene, loxP site, neomycin resistance cassette, FRT site, and loxP site upstream of exon 2. An additional loxP site was inserted downstream of the coding sequence in exon 9. Flp-mediated recombination removed the reporter/selection cassette and left exons 2 through 9 floxed. (J:299154)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Coasy Mutation:  8 strains or lines available
References
Original:  J:299154 Di Meo I, et al., Neuronal Ablation of CoA Synthase Causes Motor Deficits, Iron Dyshomeostasis, and Mitochondrial Dysfunctions in a CoPAN Mouse Model. Int J Mol Sci. 2020 Dec 19;21(24):9707
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
05/10/2022
MGI 6.19
The Jackson Laboratory