Stag2^tm1.1Alos
Targeted Allele Detail

Summary

• Symbol: Stag2^tm1.1Alos
• Name: STAG2 cohesin complex component; targeted mutation 1.1, Ana Losada
• MGI ID: MGI:6490260
• Synonyms: Stag2^lox
• Gene: Stag2 Location: ChrX:41238194-41366062 bp, + strand Genetic Position: ChrX, 23.19 cM, cytoband A2
• Alliance: Stag2^tm1.1Alos page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:298088
• Parent Cell Line: G4 (ES Cell)
• Strain of Origin: (129S6/SvEvTac x C57BL/6NCrl)F1

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: The PG00032_A_D11-3 (EUCOMM) targeting vector inserted loxP sites around exon 7 and a SA-lacZ-Neo cassette flanked by FRT sites in intron 6. Flp-mediated recombination removed the reporter/selection cassette. (J:298088)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Stag2 Mutation: 15 strains or lines available

References

• Original: J:298088 De Koninck M, et al., Essential Roles of Cohesin STAG2 in Mouse Embryonic Development and Adult Tissue Homeostasis. Cell Rep. 2020 Aug 11;32(6):108014
• All: 1 reference(s)