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Slco2b1tm1d(KOMP)Wtsi
Targeted Allele Detail
Nomenclature
Symbol: Slco2b1tm1d(KOMP)Wtsi
Name: solute carrier organic anion transporter family, member 2b1; targeted mutation 1d, Wellcome Trust Sanger Institute
MGI ID: MGI:6489390
Synonyms: OATP2B1-, Oatp2b1-deficient
Gene: Slco2b1  Location: Chr7:99307011-99360547 bp, - strand  Genetic Position: Chr7, 54.11 cM
Mutation
origin
Mutant Cell Line:  EPD0099_1_B03
Germline Transmission:  Earliest citation of germline transmission: J:287311
Parent Cell Line:  JM8.N4 (ES Cell)
Strain of Origin:  C57BL/6N
Project Collection: KOMP-CSD
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion     Vector: L1L2_Bact_P
 
Mutation detailsThe L1L2_Bact_P cassette was inserted at position 99689468 of Chromosome 7 upstream of the critical exon(s) (Build GRCm38). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by a neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. A third loxP site is inserted downstream of the targeted exon(s) at position 99688590. The critical exon(s) is/are thus flanked by loxP sites. A null/knockout allele was created by flp and cre recombinase expression in mice carrying this allele to remove the lacZ sequence, neo selection cassette and the loxP-flanked critical exon(s). Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml (J:287311)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Slco2b1 Mutation:  20 strains or lines available
References
Original:  J:287311 Chen M, et al., Role of Oatp2b1 in Drug Absorption and Drug-Drug Interactions. Drug Metab Dispos. 2020 May;48(5):420-426
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
01/12/2022
MGI 6.17
The Jackson Laboratory